Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 47

System / cell line: spots ✕ Assay: analysis ✕ Clear

Protein expression patterns in primary carcinoma of the vagina.

PMID 15199389 · PMC2409807 · British journal of cancer · 2004 · 5 claims · 4 setups

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Cluster analysis of 2-DE proteomic data allows accurate discrimination between normal vaginal mucosa, primary vaginal carcinoma and primary cervical carcinoma

fresh-frozen excised normal same two-dimensional matrix-assisted hierarchical
Proteomic analysis of serum in lung cancer induced by 3-methylcholanthrene.

PMID 19794824 · PMC2753780 · Journal of biomedicine & biotechnology · 2009 · 7 claims · 4 setups

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141 protein spots are differentially expressed between normal rat sera and MCA-induced lung cancer rat sera (82 overexpressed, 59 underexpressed)

serum lung excised two-dimensional maldi-tof-ms histopathology
Mutation analysis of congenital cataract in a Basotho family identified a new missense allele in CRYBB2.

PMID 19649175 · PMC2718852 · Molecular vision · 2009 · 8 claims · 6 setups

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A heterozygous missense mutation c.607G>A in exon 6 of CRYBB2, causing p.Val187Met, is the probable causative mutation for congenital nuclear cataract in this family

genomic basotho pcr restriction secondary
The synovial proteome: analysis of fibroblast-like synoviocytes.

PMID 15059280 · PMC400437 · Arthritis research & therapy · 2004 · 7 claims · 5 setups

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2D-PAGE combined with MALDI mass spectrometry can characterize the FLS cellular proteome with high confidence

fibroblast-like excised fls computational 2d-page in-gel maldi
Comparative proteome analysis of breast cancer and adjacent normal breast tissues in human.

PMID 17127214 · PMC5054074 · Genomics, proteomics & bioinformatics · 2006 · 8 claims · 7 setups

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15 differential protein spots were detected in 11 of 12 (91.7%) breast cancer tissue samples compared with adjacent normal tissue

breast spots 2d-page stained sds-page 2d-page maldi-tof
Microproteomics: analysis of protein diversity in small samples.

PMID 18271009 · PMC2743962 · Mass spectrometry reviews · 2008 · 8 claims · 8 setups

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Changes in gene/mRNA expression often do not correlate well with changes in protein expression, due to precursor cleavage, post-translational modification, localization, and variable protein lifetimes.

lcm-dissected single few dense gel maldi capillary
In vivo pharmaco-proteomic analysis of hydroxyurea induced changes in the sickle red blood cell membrane proteome.

PMID 19914412 · PMC2818491 · Journal of proteomics · 2010 · 8 claims · 4 setups

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2D-DIGE combined with tandem mass spectrometry identified 32 distinct sickle RBC membrane proteins that significantly changed in abundance after in vivo HU therapy

sickle excised patients 2d-dige tandem immunoblot
Proteome analysis enables separate clustering of normal breast, benign breast and breast cancer tissues.

PMID 12865921 · PMC2394238 · British journal of cancer · 2003 · 6 claims · 3 setups

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Hierarchical cluster analysis of 2-DE proteome data can distinguish normal breast, benign breast, and breast cancer tissues based on protein expression profiles

breast two-dimensional hierarchical mann-whitney
Measurement reproducibility in the early stages of biomarker development.

PMID 15665389 · PMC3839328 · Disease markers · 2004 · 6 claims · 3 setups

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Functional PCA can be used as the basis for gauge R&R (repeatability and reproducibility) assessment of mass spectra without prior identification of which spectral features are biomarkers

pooled same registered seldi-tof univariate functional
Association of poly-purine/poly-pyrimidine sequences with meiotic recombination hot spots.

PMID 16846522 · PMC1543642 · BMC genomics · 2006 · 7 claims · 6 setups

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PPT frequency is significantly elevated in yeast meiotic recombination hot spots compared with cold spots

cerevisiae genome chimpanzee hot computational microarray comparative
Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: proteomic analysis of human synaptosomes.

PMID 19693676 · PMC2824116 · Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010 · 8 claims · 7 setups

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Proteomic screening of human synaptosomes identifies a set of proteins differentially expressed in HIV/AIDS brain

frontal excised synaptosome paraffin-embedded 2d-page maldi-tof western
Proteomic analysis of aqueous humor from patients with myopia.

PMID 18334949 · PMC2268849 · Molecular vision · 2008 · 7 claims · 6 setups

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Total protein concentration in AH is significantly greater in high myopia patients than in non-myopic controls

aqueous gels silver-stained trypsin-digested bradford two-dimensional silver
A proteomic analysis of IVF follicular fluid in women

PMID 18980758 · PMC3916005 · Fertility and sterility · 2009 · 8 claims · 4 setups

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2D-PAGE proteomic evaluation of follicular fluid can identify potential biomarkers distinguishing good versus poor IVF responders in matched patient pairs

follicular excised clinical polyacrylamide liquid direct
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.

PMID 19859740 · PMC2939908 · Human genetics · 2010 · 7 claims · 7 setups

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NOS2 promoter haplotypes are not consistently associated with malaria severity or malarial anemia across three independent Tanzanian study populations

tanzanian a549 muheza-tanga sscp pcr restriction
Involvement of potential pathways in malignant transformation from oral leukoplakia to oral squamous cell carcinoma revealed by proteomic analysis.

PMID 19691830 · PMC2746235 · BMC genomics · 2009 · 7 claims · 6 setups

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85 proteins are differentially and consistently expressed (>2-fold change, P<0.05) between paired OLK and OSCC tissues, including 52 up-regulated and 33 down-regulated proteins

paired list differentially oscc 2-de gene interaction
Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass.

PMID 18824761 · PMC2629397 · Circulation · 2008 · 8 claims · 3 setups

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CP/CPB causes multiple consistent, reproducible changes in the human myocardial (right atrial) protein profile

right excised 2-dimensional tandem sds-page
Proteomic comparison of two-dimensional gel electrophoresis profiles from human lung squamous carcinoma and normal bronchial epithelial tissues.

PMID 15626334 · PMC5172349 · Genomics, proteomics & bioinformatics · 2003 · 8 claims · 5 setups

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Well-resolved, reproducible 2-DE profiles of human lung squamous carcinoma and normal bronchial epithelial tissues were obtained under optimized conditions (0.75-mg protein load, TCA precipitation)

lung scanned excised peptide 2-d 2-de maldi-tof-ms
The promise of biomarkers in colorectal cancer detection.

PMID 15322316 · PMC3839323 · Disease markers · 2004 · 8 claims · 8 setups

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A panel/combination of biomarkers is likely to provide better predictive value for early CRC detection than any single biomarker.

stool specimens serum multi-target afb1-n7-guanine mutation
Using proteomic approach to identify tumor-associated antigens as markers in hepatocellular carcinoma.

PMID 18672925 · PMC2680441 · Journal of proteome research · 2008 · 8 claims · 6 setups

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34 immunoreactive protein spots were detected in 2DE Western blots probed with HCC patient sera but not normal sera

hepg2 excised identified recombinant two-dimensional western in-gel
Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using in vitro cultured epithelial cells derived from the cancer tissues.

PMID 18416831 · PMC2377273 · BMC cancer · 2008 · 6 claims · 4 setups

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Three protein spots were significantly altered in abundance between metastase-positive and metastase-negative breast cancer patient groups

excised formalin-fixed log-normalized two-dimensional liquid immunohistochemistry

Experiments

Protein expression patterns in primary carcinoma of the vagina.

Proteomic analysis of serum in lung cancer induced by 3-methylcholanthrene.

Mutation analysis of congenital cataract in a Basotho family identified a new missense allele in CRYBB2.

The synovial proteome: analysis of fibroblast-like synoviocytes.

Comparative proteome analysis of breast cancer and adjacent normal breast tissues in human.

Microproteomics: analysis of protein diversity in small samples.

In vivo pharmaco-proteomic analysis of hydroxyurea induced changes in the sickle red blood cell membrane proteome.

Proteome analysis enables separate clustering of normal breast, benign breast and breast cancer tissues.

Measurement reproducibility in the early stages of biomarker development.

Association of poly-purine/poly-pyrimidine sequences with meiotic recombination hot spots.

Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: proteomic analysis of human synaptosomes.

Proteomic analysis of aqueous humor from patients with myopia.

A proteomic analysis of IVF follicular fluid in women

Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.

Involvement of potential pathways in malignant transformation from oral leukoplakia to oral squamous cell carcinoma revealed by proteomic analysis.

Pilot proteomic profile of differentially regulated proteins in right atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass.

Proteomic comparison of two-dimensional gel electrophoresis profiles from human lung squamous carcinoma and normal bronchial epithelial tissues.

The promise of biomarkers in colorectal cancer detection.

Using proteomic approach to identify tumor-associated antigens as markers in hepatocellular carcinoma.

Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using in vitro cultured epithelial cells derived from the cancer tissues.