Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 200

System / cell line: western ✕ Assay: analysis ✕ Clear

93rd Annual Meeting of the American Association for Cancer Research, San Francisco, CA, USA, 6-10 April 2002.

PMID 12100742 · PMC138737 · Breast cancer research : BCR · 2002 · 8 claims · 8 setups

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Serial analysis of gene expression identifies genes preferentially expressed in ductal carcinoma in situ

breast laser serum bladder cdna western seldi-tof
Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.

PMID 19094986 · PMC3388947 · Experimental eye research · 2009 · 8 claims · 3 setups

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Three lead hhRz candidates (CUC↓266, CUC↓1411, AUA↓1414) significantly knock down human RHO protein expression relative to control (p<0.05)

rho expression secondary western dicistronic
Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein.

PMID 16542425 · PMC1431555 · BMC cancer · 2006 · 8 claims · 5 setups

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ICAT tandem MS can identify and quantify differences in specific protein expression between NAF from tumor-bearing and disease-free breasts

paired icat-labeled spectra naf icat sds-page liquid
Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.

PMID 19833877 · PMC2797941 · Diabetes · 2010 · 7 claims · 5 setups

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Mitochondrial protein abundance is decreased in insulin-resistant (obese and type 2 diabetic) skeletal muscle

skeletal volunteers bsa shotgun euglycemic-hyperinsulinemic immunoblot
System-based proteomic analysis of the interferon response in human liver cells.

PMID 15287976 · PMC507879 · Genome biology · 2004 · 7 claims · 4 setups

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ICAT-based quantitative proteomics identified 1,364 proteins in Huh7 cells at <5% false-positive rate, with 54 induced and 24 repressed >2-fold by IFN treatment

huh7 computational icat gene interaction
A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes.

PMID 9449708 · PMC2212124 · The Journal of experimental medicine · 1998 · 8 claims · 8 setups

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A gene, SART-1, encoding antigenic peptides recognized by HLA-A2601-restricted CTLs was identified from human squamous cell carcinoma cells.

ke4 normal pbmcs va13 expression northern western
Genetic microheterogeneity and phenotypic variation of Helicobacter pylori arginase in clinical isolates.

PMID 17408487 · PMC1853099 · BMC microbiology · 2007 · 8 claims · 8 setups

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Arginase activity varies more than 100-fold among H. pylori clinical isolates and laboratory-adapted strains

minimally-passaged pylori coli arginase urease heterologous
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.

PMID 19915670 · PMC2771920 · PloS one · 2009 · 8 claims · 6 setups

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Proteomic analysis of glioma samples reveals three signaling subclasses of GBM associated with predominant EGFR activation, PDGFR activation, or loss of NF1

surgical standardized glioma gbm western principal k-means
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

PMID 19738201 · PMC2857963 · Science signaling · 2009 · 8 claims · 8 setups

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A novel ligand-affinity/cross-linking proteomic methodology enables isolation of labile integrin-associated signaling complexes

α5+ computational k562 embryonic ligand tandem hierarchical
Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene.

PMID 16162288 · PMC1261261 · BMC genomics · 2005 · 8 claims · 5 setups

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A novel rTS protein isoform, rTSγ, exists with a 27-residue longer N-terminus generated from an alternative upstream start codon relative to rTSβ.

rts rtsβ ccrf-cem comparative mitochondrial subcellular
Analysis of chimpanzee history based on genome sequence alignments.

PMID 18421364 · PMC2278377 · PLoS genetics · 2008 · 8 claims · 6 setups

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Bonobos and common chimpanzees separated approximately 1.29 million years ago

bonobo bonobos chimpanzee simulated shotgun sequenom principal
A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.

PMID 19942684 · PMC2817474 · Nucleic acids research · 2010 · 8 claims · 7 setups

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Exogenous RPA4 expression does not support chromosomal DNA replication and causes cell-cycle arrest in G2/M

hela mammalian rpa4 western flow immunofluorescence
Expression patterns of cardiac myofilament proteins: genomic and protein analysis of surgical myectomy tissue from patients with obstructive hypertrophic cardiomyopathy.

PMID 19808356 · PMC2765062 · Circulation. Heart failure · 2009 · 8 claims · 4 setups

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Myofilament protein levels (MYBPC3 and MYH7) are increased, not decreased, in HCM patients carrying a mutation in either gene compared to healthy heart tissue

genomic lysate formalin-fixed myectomy mutational western immunohistochemistry
Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis.

PMID 38879692 · PMC11180211 · Communications biology · 2024 · 7 claims · 7 setups

Has reproduction · 69

Epithelial cell populations are significantly reduced during acute DSS colitis, reflecting tissue damage, with partial recovery in chronic colitis

colon gut single-cell 16s western
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.

PMID 33420019 · PMC7794422 · Nature communications · 2021 · 8 claims · 8 setups

Has reproduction · 50

SNAI2 is highly expressed in FN-RMS tumors and cell lines compared to normal tissue

rms fn-rms fp-rms imr90 rna-seq western immunohistochemistry
A new family of giardial cysteine-rich non-VSP protein genes and a novel cyst protein.

PMID 17183673 · PMC1762436 · PloS one · 2006 · 8 claims · 7 setups

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HCNCp is a novel invariant (non-variant) cyst protein belonging to a new family of high-cysteine membrane proteins (HCMp) abundant in the Giardia genome

giardia serial northern western
Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients.

PMID 19698114 · PMC2749045 · BMC infectious diseases · 2009 · 8 claims · 7 setups

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Three PRNP mutations—D178N, E200K, and M232R—were identified in heterozygosity in Korean probable CJD patients, marking their first report in this population.

csf 293t genomic pcr western recombinant sequencing
Integrative analysis reveals chemokines CCL2 and CXCL5 mediated shear stress-induced aortic dissection formation.

PMID 38163105 · PMC10757018 · Heliyon · 2024 · 7 claims · 8 setups

Has reproduction · 75

Chemokines CCL2 and CXCL5 mediate a shear stress-induced 'Endothelial-Monocyte-Neutrophil' axis that contributes to aortic dissection development.

ascending aortic clinical bulk bulk single-cell western
TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.

PMID 33516944 · PMC7903014 · Molecular metabolism · 2021 · 7 claims · 8 setups

Has reproduction

BAT whitening at thermoneutrality is associated with TFEB-dependent mitochondrial degradation.

bat subscapular tfeb-bat-ko metabolically qrt-pcr western immunohistochemistry
Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCD(cl1) Cells.

PMID 35806266 · PMC9267015 · International journal of molecular sciences · 2022 · 8 claims · 7 setups

Has reproduction · 76

mCCD cl1 cells mount a broad transcriptional response to 24 h hypoxia (0.2% O2), with 3086 genes differentially expressed

mccd lines bulk rt-qpcr western

Experiments

93rd Annual Meeting of the American Association for Cancer Research, San Francisco, CA, USA, 6-10 April 2002.

Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.

Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein.

Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.

System-based proteomic analysis of the interferon response in human liver cells.

A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes.

Genetic microheterogeneity and phenotypic variation of Helicobacter pylori arginase in clinical isolates.

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene.

Analysis of chimpanzee history based on genome sequence alignments.

A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.

Expression patterns of cardiac myofilament proteins: genomic and protein analysis of surgical myectomy tissue from patients with obstructive hypertrophic cardiomyopathy.

Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis.

Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.

A new family of giardial cysteine-rich non-VSP protein genes and a novel cyst protein.

Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients.

Integrative analysis reveals chemokines CCL2 and CXCL5 mediated shear stress-induced aortic dissection formation.

TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.

Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCD(cl1) Cells.