Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 45

System / cell line: type ✕ Assay: antibody ✕ Clear

Functional characterisation of the TSC1-TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex.

PMID 18302728 · PMC2291454 · BMC medical genetics · 2008 · 8 claims · 8 setups

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Functional assays of TSC1–TSC2 complex activity can distinguish pathogenic TSC2 mutations from rare polymorphisms when multiple variants segregate in one family

hek immunoprecipitated tsc2 peripheral coimmunoprecipitation rheb s6k-t389
Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus.

PMID 17177599 · PMC1702557 · PLoS medicine · 2006 · 8 claims · 4 setups

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30 of 160 measured serum analytes (cytokines, chemokines, growth factors, soluble receptors) are dysregulated in SLE serum

serum blood peripheral custom luminex blood
ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms.

PMID 41800619 · PMC13171160 · Cell reports · 2026 · 8 claims · 8 setups

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Human ADAR1 downregulates self-dsRNA abundance through both editing-dependent and editing-independent mechanisms

hek-293t adar1 dermal e912a antibody western nuclease
Functional analysis of human mutations in homeodomain transcription factor PITX3.

PMID 17888164 · PMC2093940 · BMC molecular biology · 2007 · 7 claims · 5 setups

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Both S13N and G219fs mutants show partial loss-of-function in DNA-binding and/or transactivation activity, with G219fs more severely affected than S13N

lens western immunocytochemistry electrophoretic
beta- Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis.

PMID 11161379 · PMC2363713 · British journal of cancer · 2001 · 7 claims · 4 setups

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Cell membrane β-catenin immunoreactivity shows a stepwise decrease from normal endometrium, through atypical hyperplasia, to grade 3 carcinoma.

endometrial immunohistochemistry rt-pcr pcr
The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.

PMID 19050890 · PMC2690858 · Annals of hematology · 2009 · 7 claims · 7 setups

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HBG2:g.-109G>T is a novel promoter mutation causing a distinct ('Hellenic type') nd-HPFH

peripheral genomic nuclear mel cation reverse-phase denaturing
Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.

PMID 18957049 · PMC2586876 · Xenotransplantation · 2008 · 8 claims · 6 setups

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Non-Gal antibody response after cardiac xenotransplantation is directed to a diverse set of stress response, inflammation-related, cytoskeletal and metabolic pig EC antigens, with several immunodominant targets remaining undefined

gt-ko spots explanted flow western nanolc
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.

PMID 7606775 · PMC3730239 · Cell · 1995 · 6 claims · 8 setups

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Expression of a specific var gene (A4var) correlates with A4 antigenic type and with binding to ICAM-1

falciparum cdna c18 genomic rt-pcr southern genomic
Longitudinal analysis of early stage sarcopenia in aging rhesus monkeys.

PMID 18983905 · PMC2693938 · Experimental gerontology · 2009 · 8 claims · 6 setups

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mtDNA deletion mutations induce ETS enzyme abnormalities (COXneg/SDHhyp phenotypes) linked to intra-fiber atrophy and fiber loss

rhesus vastus muscle single dual hematoxylin immunohistochemistry
Three assays show differences in binding of wild-type and mutant p53 to unique gene sequences.

PMID 19925028 · PMC2917581 · Technology in cancer research & treatment · 2009 · 7 claims · 6 setups

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Three different DNA binding assays (EMSA, SPA, streptavidin magnetic bead assay) show differences in binding of wild-type and mutant p53 to unique gene sequences

nuclear wro electrophoretic binding streptavidin
TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis.

PMID 41492090 · PMC12858408 · Nature cancer · 2026 · 7 claims · 8 setups

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TGFβ initially induces a full, typical EMT (stress fibers, loss of epithelial markers, motility) in dormancy-competent LUAD progenitors that subsequently transitions into an atypical spheroidal mesenchymal state lacking actin stress fibers.

h2087-lcc m802t4-lcc reconstructed immunofluorescence antibody-mediated
Müller glial and microglial responses coupled to recovery of cone photoreceptors following limited cone ablation in zebrafish retina.

PMID 41691075 · PMC12992573 · Scientific reports · 2026 · 7 claims · 6 setups

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24-hour 10mM Mtz immersion of adult gnat2:nfsb-mCherry zebrafish causes death of only a limited number of cone photoreceptors rather than widespread ablation

retinal retina dissociated live tunel immunofluorescence rt-qpcr
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.

PMID 21857667 · PMC3173870 · Nature cell biology · 2011 · 8 claims · 8 setups

Has reproduction · 90

Brain tumors in l(3)mbt mutants originate from overproliferation of neuroepithelial cells of the optic lobes, not from defects in asymmetric cell division.

drosophila chip-seq chip immunostaining
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.

PMID 17713557 · PMC2435172 · Genes and immunity · 2007 · 7 claims · 8 setups

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SNPs in LECT2 and TGFBI show independent associations with the DTH+ phenotype, indicating two separate genes in this region control DTH+

blood family unrelated subjects snp family-based linkage
HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.

PMID 41807716 · PMC13096512 · Scientific reports · 2026 · 8 claims · 8 setups

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OS activity is significantly elevated in AD and shows pronounced heterogeneity across brain cell types

entorhinal brain middle c57bl scrna-seq bulk animal
MultiPert: An adversarial alignment and dual attention framework for single-cell multi-omics perturbation prediction.

PMID 41811907 · PMC12998955 · PLoS computational biology · 2026 · 8 claims · 7 setups

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MultiPert reliably predicts both perturbed gene expression and protein abundance profiles from single-cell multi-omics data

thp-1 kidney gse156478 computational zinb-vae autoencoder eccite-seq
Finding the needle in the haystack: why high-throughput screening is good for your health.

PMID 12100740 · PMC138735 · Breast cancer research : BCR · 2002 · 8 claims · 8 setups

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HTS is essential for finding lead compounds, especially for novel targets whose active-site structure is unknown

raf-1 mitotic mutant tumor biochemical cell-based conformational
Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes.

PMID 17175541 · PMC1802633 · Nucleic acids research · 2007 · 7 claims · 7 setups

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A typical MHC-II-like S-Y module is present upstream of the RAB4B transcription start site, identified by genome-wide profile scanning

genomic raji monocyte-derived rj2.2.5 computational chip-on-chip chromatin
Chromatin state architecture governs transcription factor accessibility across plant genomes.

PMID 41570051 · PMC12867329 · PLoS genetics · 2026 · 8 claims · 8 setups

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Chromatin states show a large degree of functional conservation between Arabidopsis thaliana and Marchantia polymorpha across more than 450 million years of land plant evolution

arabidopsis marchantia chromhmm atac-seq antibody-based
CCL3+ Neutrophil Signature Predicts Response to Neoadjuvant Toripalimab plus Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Phase II Trial.

PMID 41817286 · PMC13223550 · Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · 7 claims · 8 setups

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A proinflammatory, CCL3-high neutrophil subset (Neu_CCL3) is significantly enriched in the pretreatment tumor microenvironment of patients who respond to nCIT.

pretreatment microarray cohorts moc1 single-cell bulk immunohistochemistry

Experiments

Functional characterisation of the TSC1-TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex.

Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus.

ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms.

Functional analysis of human mutations in homeodomain transcription factor PITX3.

beta- Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis.

The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.

Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.

Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes.

Longitudinal analysis of early stage sarcopenia in aging rhesus monkeys.

Three assays show differences in binding of wild-type and mutant p53 to unique gene sequences.

TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis.

Müller glial and microglial responses coupled to recovery of cone photoreceptors following limited cone ablation in zebrafish retina.

The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.

Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.

HIF3A-mediated aberrant activation of TXNIP promotes Alzheimer's disease progression.

MultiPert: An adversarial alignment and dual attention framework for single-cell multi-omics perturbation prediction.

Finding the needle in the haystack: why high-throughput screening is good for your health.

Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes.

Chromatin state architecture governs transcription factor accessibility across plant genomes.

CCL3+ Neutrophil Signature Predicts Response to Neoadjuvant Toripalimab plus Chemotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Phase II Trial.