Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.

  PMID 41776310 · PMC13004687 · Nature aging · 2026 · 8 claims · 7 setups

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  Young and estropausal female mice have distinct, separable gut microbial profiles (beta and alpha diversity) across multiple cohorts.

  fecal young gut vcd-induced 16s ovarian picrust2

• Dysregulation of alternative splicing patterns in the ovaries of reproductively aged mice.

  PMID 41630016 · PMC13046076 · Reproduction (Cambridge, England) · 2026 · 8 claims · 5 setups

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  Reproductive aging in mouse ovaries is associated with widespread alternative splicing changes, including shifts in exon usage, splice site selection, and transcript boundaries.

  ovary computational direct cryosectioning translation

• Blood-based epigenetic instability linked to human aging and disease.

  PMID 41690920 · PMC13018287 · Nature communications · 2026 · 7 claims · 8 setups

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  31,744 unmethylated (and 6143 methylated) CpG loci in blood show highly consistent, stable methylation in young healthy individuals and are defined as Epigenetically Stable Loci (ESLs)

  blood normal paired aml illumina whole-genome methylation

• ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement.

  PMID 41668152 · PMC12990438 · Genome biology · 2026 · 8 claims · 7 setups

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  Senescence-associated marker genes show weak, non-specific expression across human tissues and cell types compared to canonical tissue/cell-type markers

  tissues pancreas pancreatic brain bulk scrna-seq train

• Epistemic uncertainty challenges aging clock reliability in predicting rejuvenation effects.

  PMID 39072888 · PMC11561706 · Aging cell · 2024 · 8 claims · 8 setups

  Has reproduction · 93

  DNA methylation profiles observed across cellular reprogramming are poorly represented in the training data of existing aging clocks, introducing high out-of-distribution/epistemic uncertainty in their age estimates

  males skin liver linear dnam epigenetic