Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Epigenetic and Transcriptional Programs Define Osteosarcoma Subtypes and Establish Targetable Vulnerabilities.
PMID 41037662 · PMC12877751 · Cancer discovery · 2026 · 8 claims · 7 setups
ATAC-seq profiling of osteosarcoma patient samples, PDXs, and PDX-CLs reveals two distinct chromatin accessibility subtypes: early osteoblast-derived (EOD) and late osteoblast-derived (LOD)
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Has reproduction · 73
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia.
PMID 39820365 · PMC11739599 · Nature communications · 2025 · 8 claims · 8 setups
RSK1 is a conserved, exploitable therapeutic dependency across MPN and secondary AML
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LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture.
PMID 41489510 · PMC13040219 · Cancer discovery · 2026 · 8 claims · 8 setups
LINE-1 RNAs are primarily chromatin-associated nascent transcripts rather than cytosolic mRNAs
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MECOM Function Is Critical for AR-Driven Treatment-Resistant Prostate Cancer.
PMID 41529070 · PMC13136877 · Cancer research · 2026 · 7 claims · 8 setups
EVI1, encoded by MECOM, is an AR-recruited coactivator of noncanonical AR signaling in prostate cancer.
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Has reproduction · 85
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.
PMID 33634984 · PMC7882098 · Clinical and translational medicine · 2021 · 8 claims · 8 setups
JMJD6 is identified as a potent epigenetic vulnerability/fitness gene in RCC by integrating GeCK CRISPR screening data with TCGA-KIRC epigenetic regulator survival analysis