Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 62
scATD: a high-throughput and interpretable framework for single-cell cancer drug resistance prediction and biomarker identification.
PMID 40501071 · PMC12159290 · Briefings in bioinformatics · 2025 · 8 claims · 6 setups
scATD enables high-throughput single-cell drug sensitivity prediction for new patients without model parameter retraining via bidirectional Bi-AdaIN style transfer
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Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome.
PMID 41707652 · PMC12923947 · Cell reports. Medicine · 2026 · 8 claims · 6 setups
Proliferating (KI67+) PROX1+ lymphatic endothelial cells (LECs) at the tumor invasive margin are a strong independent adverse prognostic factor for recurrence-free and overall survival in early-stage OSCC
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Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 expression in microglia during Alzheimer's disease progression.
PMID 41580850 · PMC12911240 · Journal of translational medicine · 2026 · 7 claims · 8 setups
A TIM-3+ microglial subset drives AD pathogenesis through a dual mechanism: sustained neuroinflammation via TNF-α/NF-κB and IL-6/JAK/STAT3 signaling, and impaired amyloid-β clearance linked to PI3K-AKT and FcγR pathways
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Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.
PMID 41644568 · PMC12982522 · Nature communications · 2026 · 8 claims · 6 setups
MM is not characterized by T cell exhaustion but by antigen-driven terminal memory differentiation, unlike solid cancers
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Has reproduction · 49
Integrative transcriptomics and single-cell transcriptomics analyses reveal potential biomarkers and mechanisms of action in papillary thyroid carcinoma.
PMID 40520228 · PMC12162626 · Frontiers in genetics · 2025 · 8 claims · 8 setups
ENTPD1, SERPINA1, and TACSTD2 are potential transcriptomic biomarkers for PTC
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Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILI.
PMID 41858622 · PMC12995703 · iScience · 2026 · 8 claims · 8 setups
Cdkn1a and Pdk1 are key PANoptosis-related genes with high diagnostic potential for AILI
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Radiogenomics predicts immune microenvironment heterogeneity and response to combination immunotherapy in hepatocellular carcinoma.
PMID 41555384 · PMC12895822 · Journal of translational medicine · 2026 · 8 claims · 8 setups
A parsimonious 2-gene immune-related signature (IRS = 0.425×KPNA2 + 0.302×SMG5) is significantly associated with immune heterogeneity and response to ICI plus anti-angiogenic combination therapy in HCC
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Genomic biomarkers of immunotherapy plus chemotherapy in patients with advanced NSCLC: Insights from the phase 3 ORIENT-11 study.
PMID 41660271 · PMC12876322 · iScience · 2026 · 8 claims · 8 setups
A 9-gene Immune-Chemotherapy Prediction Score (ICPscore), derived from ORIENT-11 via WGCNA and LASSO Cox regression, predicts survival benefit from ICI plus chemotherapy in advanced NSCLC
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Development and validation of an oxidative phosphorylation based prognostic model revealing tumor progression and immune microenvironment in lung adenocarcinoma.
PMID 41670771 · PMC12996521 · Discover oncology · 2026 · 8 claims · 8 setups
OXPHOS activity is significantly elevated in LUAD tumor tissue compared to adjacent normal tissue