Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 4

System / cell line: saccharomyces ✕ Assay: blood ✕ Clear

Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion.

PMID 19065272 · PMC2588657 · PloS one · 2008 · 6 claims · 5 setups

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Heterozygous UCP2 coding variants (parentally inherited) were identified in 2 of 10 CHI patients with no mutations in known CHI genes

peripheral saccharomyces yeast ins-1e dhplc proton western
Nucleosome deposition and DNA methylation at coding region boundaries.

PMID 19723310 · PMC2768978 · Genome biology · 2009 · 8 claims · 8 setups

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Nucleosomes and DNA methylation form distinct peaks just downstream of the start codon and just upstream of the stop codon, marking both ends of protein coding units genome-wide.

yeast drosophila resting naive nucleosome methylation pol
The limits of reductionism in medicine: could systems biology offer an alternative?

PMID 16681415 · PMC1459480 · PLoS medicine · 2006 · 8 claims · 3 setups

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Reductionist medical science (focus on singular causal factors, homeostasis-as-normal-range, one-risk-factor epidemiology, additive treatment of comorbidities) has inherent limitations for explaining complex disease behavior

escherichia population genome mathematical epidemiological genome
Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue.

PMID 16426447 · PMC1373649 · BMC medical genetics · 2006 · 7 claims · 4 setups

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MSI status can be determined in the absence of proband non-tumor tissue by comparing tumor alleles to alleles carried by the proband's progenitors

proband's peripheral hmsh2 microsatellite direct targeted

Experiments

Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion.

Nucleosome deposition and DNA methylation at coding region boundaries.

The limits of reductionism in medicine: could systems biology offer an alternative?

Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue.