Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids.

  PMID 29983891 · PMC6033374 · Oncotarget · 2018 · 7 claims · 6 setups

  Has reproduction · 65

  UC patient-derived organoids histologically phenocopy primary UC tissue, showing disorganized stratified epithelium, reduced mucin/goblet cells, and non-uniform proliferation compared to non-IBD organoids

  patient-derived h3k27ac rna-seq chip-seq histology

• Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish.

  PMID 41546624 · PMC12958812 · G3 (Bethesda, Md.) · 2026 · 8 claims · 5 setups

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  Ubiquitous overexpression of zGli3R (Tg(ubb:zGli3R)) causes widespread changes to the 30 hpf zebrafish embryonic transcriptome

  hpf dpf bulk gene bright-field

• Functional human salivary gland organoids for tissue regeneration in chemically defined culture systems.

  PMID 41707649 · PMC12923968 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  A chemically defined, Matrigel-free complete medium (CM) generates hSGOs with more cohesive spheroid morphology, organized epithelial layers, and improved apical polarization compared to keratinocyte medium (KM-S) or Matrigel-embedded conditions

  submandibular smg-derived hsgos smg bright-field h&e single-factor

• A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development.

  PMID 41957362 · PMC13066550 · Nature communications · 2026 · 8 claims · 7 setups

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  A 3 bp deletion or a 1 bp insertion in the Enh13 SOX9 binding site causes complete XX female-to-male sex reversal in adult homozygous mice

  c57bl6 6-week-old 6-week e12.5 crispr-cas9 gross immunostaining

• Genomic instability and mono-parental expression mitigate genomic shock in a cross-subgenus Leishmania hybrid.

  PMID 41918820 · PMC13034039 · NAR molecular medicine · 2026 · 7 claims · 8 setups

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  An in vitro cross between L. infantum and L. tarentolae produced a viable inter-subgenus hybrid, demonstrating genomic compatibility between highly divergent Leishmania species.

  infantum linf-gfp bone bmdms genetic flow morphological