Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.

  PMID 41592025 · PMC13038201 · The Journal of clinical investigation · 2026 · 7 claims · 8 setups

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  Myeloid-lineage cells (monocytes, macrophages, myeloid progenitors) show the highest expression of p16 and SASP markers among bone marrow immune cell types in aged mice

  bone femur skeletal single-cell mass cytof

• ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement.

  PMID 41668152 · PMC12990438 · Genome biology · 2026 · 8 claims · 7 setups

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  Senescence-associated marker genes show weak, non-specific expression across human tissues and cell types compared to canonical tissue/cell-type markers

  tissues pancreas pancreatic brain bulk scrna-seq train

• Single-cell dissection of regulated cell death dynamics in ovarian aging.

  PMID 41689119 · PMC13005338 · Journal of ovarian research · 2026 · 8 claims · 8 setups

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  The RCD landscape of ovarian aging had not previously been characterized at single-cell resolution

  ovary serum scrna-seq bulk single-nucleus

• Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response.

  PMID 41720793 · PMC13035812 · Nature communications · 2026 · 8 claims · 8 setups

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  Lifelong CR reduces white blood cell production and shifts hematopoiesis toward myeloid and thrombo-erythroid lineages while suppressing lymphoid output

  peripheral sorted young aged complete flow bulk

• Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.

  PMID 41776310 · PMC13004687 · Nature aging · 2026 · 8 claims · 7 setups

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  Young and estropausal female mice have distinct, separable gut microbial profiles (beta and alpha diversity) across multiple cohorts.

  fecal young gut vcd-induced 16s ovarian picrust2