Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Af-CUT&Tag: a sensitive and antibody-free chromatin profiling method using genetically encoded tags and high-affinity binders fused to Tn5.
PMID 41547832 · PMC12914055 · Nature communications · 2026 · 8 claims · 8 setups
Af-CUT&Tag eliminates dependence on conventional target antibodies by using CRISPR-integrated HiBiT/ALFA-tags recognized by LgBiT/NbALFA-Tn5 fusion proteins
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Remodeling of XIST regulatory landscape during primate evolution.
PMID 41544163 · PMC12810636 · Science advances · 2026 · 8 claims · 8 setups
XIST regulation has diverged uniquely and rapidly between closely related primates: JPX is a major XIST regulator in human and marmoset ESCs but only a minor regulator in macaque ESCs
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Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding.
PMID 41639407 · PMC12900649 · Nature genetics · 2026 · 8 claims · 8 setups
Acute HDAC inhibition (TSA pulse) induces genome-wide H3K27 hyperacetylation and reorganizes the histone modification landscape, shifting more of the genome to an active state.
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Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine-Dependent Pro-Inflammatory Immune Microenvironment.
PMID 41580972 · PMC13042394 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups
T cell-specific Socs1 loss intrinsically drives pro-inflammatory T cell differentiation independent of antigen stimulation, with the strongest effects in CD8+ T cells