Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 15

System / cell line: cell-type ✕ Assay: causal ✕ Clear

Unraveling the Causal Linkages of RBP7 and SCGB3A1 on Pelvic Organ Prolapse: Multifaceted Insights From Genome-Wide Mendelian Randomization, Single-Cell RNA Analysis, and Network Pharmacology.

PMID 41497737 · PMC12765987 · BioMed research international · 2026 · 8 claims · 7 setups

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High RBP7 expression causally increases POP risk

vaginal gwas rbp7 key single-cell mendelian protein-protein
Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target.

PMID 41820721 · PMC13096280 · Discover oncology · 2026 · 8 claims · 8 setups

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BMI and LUSC show a significant positive genome-wide genetic correlation, robust to constrained-intercept sensitivity analysis and replicated by GNOVA.

gwas gtex scrna-seq ldsc gnova ρ-hess
A causal glycerophospholipid-IL-18R1-CD9 axis connects lipid metabolism and T-cell activation in atopic dermatitis.

PMID 42061907 · PMC13132603 · Briefings in bioinformatics · 2026 · 7 claims · 8 setups

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1-palmitoyl-2-arachidonoyl-GPC (PA-GPC) is a protective metabolite against AD that acts primarily by downregulating IL-18R1

gwas skin training keratinocyte linkage two-sample bayesian
Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations.

PMID 41811178 · PMC12978698 · eLife · 2026 · 8 claims · 8 setups

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Cell type-specific Bayesian and co-expression networks generated from BMSC-OB scRNA-seq data in Diversity Outbred mice can prioritize and contextualize genes underlying human BMD GWAS associations

bmsc-ob genes mesenchymal gtex scrna-seq cellect iterativewgcna
SLC25A37 as a novel therapeutic target for benign prostatic hyperplasia: integrative analyses of single-cell RNA sequencing and genome-wide association studies.

PMID 41726128 · PMC12917586 · Open medicine (Warsaw, Poland) · 2026 · 8 claims · 8 setups

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SLC25A37 is causally associated with increased BPH risk, supported by MR, Bayesian colocalization, and reverse MR analyses

prostate gwas eqtl bph single-cell mendelian bayesian
Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.

PMID 42018614 · PMC13101850 · Science advances · 2026 · 8 claims · 8 setups

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DNA methylation is a plausible causal driver of gene expression in the majority (73%) of tested eQTM pairs, more often than the reverse direction (28%)

nasal genes snps types eqtm eqtl causal
Comprehensive analysis for the role of macrophage-driven genes in abdominal aortic aneurysm.

PMID 41815567 · PMC12973086 · Cardiovascular diagnosis and therapy · 2026 · 8 claims · 8 setups

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SMU1 is identified as a novel macrophage-related gene associated with AAA development, serving as a potential diagnostic biomarker and therapeutic target

aaa macrophage-related merged gwas single-cell bulk rt-qpcr
Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects.

PMID 41986506 · PMC13226668 · The EMBO journal · 2026 · 8 claims · 6 setups

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Single-cell transcriptome profiling of 245,878 islet cells from 48 donors (ND/PD/T2D) identifies 14 distinct, robust islet cell types detected in every donor

pancreatic aggregated endoc-βh3 subset droplet-based pseudobulk unsupervised
Embeddings from language models are good learners for single-cell data analysis.

PMID 41726097 · PMC12921509 · Patterns (New York, N.Y.) · 2026 · 8 claims · 8 setups

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scELMo combines LLM-derived embeddings of gene and cell metadata with raw single-cell expression data via matrix operations to generate cell embeddings without pretraining a new model

scrna-seq multi-batch diseased perturbation clustering batch cell-type
Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.

PMID 41741465 · PMC13057173 · Nature communications · 2026 · 8 claims · 7 setups

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The MTOR eQTL variant rs4845987 has context-specific, opposite effects on MTOR expression: decreasing it in activated T cells and increasing it in neutrophils.

blood bulk eqtl sepsis bulk cell-type colocalisation
LRP1 as a potential diagnostic and immunomodulatory target in endometriosis: evidence from multi-omics and single-cell analyses.

PMID 42064072 · PMC13124487 · Frontiers in immunology · 2026 · 8 claims · 8 setups

Has reproduction · 49

LRP1 is a hub gene with the highest diagnostic performance among 30 candidate hub genes identified by machine learning

ectopic geo gse5108 training microarray wgcna machine
Integrating human plasma proteomes with genome-wide association data implicates novel proteins and drug targets for rheumatoid arthritis.

PMID 41540382 · PMC12892679 · Clinical proteomics · 2026 · 8 claims · 8 setups

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PWAS integrating RA GWAS with ARIC and INTERVAL plasma pQTL data identified 35 genetically regulated proteins (42 associations) significantly associated with RA risk.

plasma shared gtex blood proteome-wide two-sample bayesian
A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.

PMID 30833571 · PMC6399342 · Nature communications · 2019 · 6 claims · 8 setups

Has reproduction · 90

A GWAS of 12,312 CTS cases and 389,344 controls in UK Biobank identifies 16 novel genome-wide significant susceptibility loci for CTS

biobank surgically gwas transformed genome-wide sequencing gene-based
Cross-ancestry genome-wide association studies of liver function biomarkers uncover pleiotropic variants, systemic disease links and therapeutic targets.

PMID 41689074 · PMC13005531 · Genome medicine · 2026 · 8 claims · 8 setups

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5,507 lead signals (P<5x10^-9) were identified for seven LFQBs across ancestries, including 210 novel loci

hope biobank combined cross-ancestry gwas cross-ancestry functional-informed
Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation.

PMID 41912493 · PMC13039830 · Translational psychiatry · 2026 · 8 claims · 8 setups

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571 shared targets identified between BPA-associated (2554) and MDD-associated (4661) genes

gene shared gwas gabaergic network ppi mendelian

Experiments

Unraveling the Causal Linkages of RBP7 and SCGB3A1 on Pelvic Organ Prolapse: Multifaceted Insights From Genome-Wide Mendelian Randomization, Single-Cell RNA Analysis, and Network Pharmacology.

Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target.

A causal glycerophospholipid-IL-18R1-CD9 axis connects lipid metabolism and T-cell activation in atopic dermatitis.

Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations.

SLC25A37 as a novel therapeutic target for benign prostatic hyperplasia: integrative analyses of single-cell RNA sequencing and genome-wide association studies.

Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.

Comprehensive analysis for the role of macrophage-driven genes in abdominal aortic aneurysm.

Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects.

Embeddings from language models are good learners for single-cell data analysis.

Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.

LRP1 as a potential diagnostic and immunomodulatory target in endometriosis: evidence from multi-omics and single-cell analyses.

Integrating human plasma proteomes with genome-wide association data implicates novel proteins and drug targets for rheumatoid arthritis.

A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.

Cross-ancestry genome-wide association studies of liver function biomarkers uncover pleiotropic variants, systemic disease links and therapeutic targets.

Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation.