Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 9

System / cell line: tumor ✕ Assay: cck8 ✕ Clear

Amelioration of colorectal cancer-associated fibroblasts in immunosuppressive microenvironment by ferroptosis-based nanotherapy.

PMID 41690961 · PMC13018587 · Nature communications · 2026 · 8 claims · 8 setups

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CAFs drive tumor-promoting activity and immunosuppression, contributing to CRC immunotherapy resistance

crc patient-derived hct116 models bioinformatic cytotoxicity bio-tem
Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

PMID 42045760 · PMC13187092 · Discover oncology · 2026 · 8 claims · 8 setups

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SPP1+ malignant and CXCR4+ TAM crosstalk drives CD8 T cell exhaustion and induces poor immunotherapy response

luad tcga-luad epithelial a549 single-cell spatial bulk
Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.

PMID 41562071 · PMC12813044 · Frontiers in immunology · 2025 · 7 claims · 8 setups

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GDPD3 is upregulated in PRAD tumor tissue and its knockdown inhibits tumor cell proliferation, invasion, and migration

prad tcga-prad du145 scrna-seq bulk wgcna
Multi-omics analyses related to mitochondria and ageing in triple-negative breast cancer implicate PYCR1 potentiates tumor progression.

PMID 41749247 · PMC13041056 · Cancer cell international · 2026 · 8 claims · 8 setups

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A 4-gene mitochondrial ageing-related risk score (MARS) model (PYCR1, MAPT, CEBPA, BCL2A1) predicts TNBC prognosis

tcga-brca gse58812 gse18728 metabric bulk single-cell immunohistochemistry
NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis.

PMID 41787028 · PMC13087130 · NPJ precision oncology · 2026 · 8 claims · 8 setups

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Elevated NDUFA4L2 expression is associated with poor survival and chemotherapy resistance in HNSCC

carcinoma hnscc cal27 oscc non-negative kaplan-meier western
Inference of Subpathway Activity Profiles Reveals Metabolism Abnormal Subpathway Regions in Glioblastoma Multiforme.

PMID 33072547 · PMC7533644 · Frontiers in oncology · 2020 · 8 claims · 7 setups

Has reproduction · 89

A GSVA-based method for constructing a metabolic subpathway activity score matrix accurately identifies abnormal GBM metabolic targets

metabolic gbm tcga u87-mg k-clique gsva-based survival
Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma.

PMID 39553728 · PMC11569783 · PeerJ · 2024 · 8 claims · 8 setups

Has reproduction · 80

WGCNA identified 214 key genes in the blue module most correlated with LUAD

tcga-luad merged tedc2-associated a549 wgcna differential machine
Smoking promotes colorectal cancer via the CKAP2L/AREG axis.

PMID 41823522 · PMC13038336 · International journal of oncology · 2026 · 8 claims · 8 setups

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Smoking is positively associated with CRC risk, confirmed by both cross-sectional (NHANES) and Mendelian randomization analyses

participants european crc hct116 cross-sectional two-sample single-cell
Single-Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re-Sensitizer Drugs in Triple-Negative Breast Cancer.

PMID 41933924 · PMC13205605 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 7 claims · 8 setups

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Ferroptosis inhibition, marked by upregulation of suppressors (e.g., FTH1, GPX4) and downregulation of drivers, underlies the evolution of JQ1 resistance in TNBC cells

sum159 sum149 six lincs scrna-seq bulk cck8

Experiments

Amelioration of colorectal cancer-associated fibroblasts in immunosuppressive microenvironment by ferroptosis-based nanotherapy.

Multi-Omics reveals SPP1 + malignant and CXCR4(+) TAM crosstalk predicts immunotherapy response in lung adenocarcinoma.

Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.

Multi-omics analyses related to mitochondria and ageing in triple-negative breast cancer implicate PYCR1 potentiates tumor progression.

NDUFA4L2 regulates the progression and chemotherapy sensitivity of HNSCC by inhibiting PANoptosis.

Inference of Subpathway Activity Profiles Reveals Metabolism Abnormal Subpathway Regions in Glioblastoma Multiforme.

Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma.

Smoking promotes colorectal cancer via the CKAP2L/AREG axis.

Single-Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re-Sensitizer Drugs in Triple-Negative Breast Cancer.