Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging.
PMID 42010880 · PMC13096584 · Aging cell · 2026 · 8 claims · 8 setups
T cells are the immune cell population with the most pronounced transcriptomic alterations during liver aging
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PD-1 antibody-bound progenitor-exhausted CD8(+) T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer.
PMID 41951588 · PMC13237225 · Nature communications · 2026 · 8 claims · 6 setups
Progenitor-exhausted CD8+ T cells (CD8-Tpex, TCF7+PDCD1+) are enriched in proximal lymph nodes and proliferate at a high rate after ICI treatment
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Has reproduction · 66
Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.
PMID 41387425 · PMC12701056 · Nature communications · 2025 · 8 claims · 8 setups
PON1 expression is downregulated in HCC tumor tissue and low PON1 is associated with worse prognosis
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ZFP148 is a transcriptional repressor of cytolytic effector CD8(+) T cell differentiation.
PMID 41896465 · PMC13043298 · Nature immunology · 2026 · 8 claims · 8 setups
ZFP148 is enriched in CD8+ T progenitor (T PRO) cells and its expression declines during differentiation into effector (T EFF) and exhausted (T EX) cells
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CEBPB-Regulated Gastric Cell Plasticity Promotes Liver Metastasis of Gastric Cancer.
PMID 41836678 · PMC12981248 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups
GC cells undergoing liver metastasis transcriptionally reprogram into a high-plasticity cell state
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Has reproduction · 48
Indoleamine 2, 3-Dioxygenase 1 and CD8 Expression Profiling Revealed an Immunological Subtype of Colon Cancer With a Poor Prognosis.
PMID 33425745 · PMC7793995 · Frontiers in oncology · 2020 · 8 claims · 8 setups
A colon cancer subtype with CD8Ahigh IDO1high tumors shows the worst survival despite high CD8 T cell infiltrates
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Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7.
PMID 41920738 · PMC13222646 · Cell reports · 2026 · 8 claims · 8 setups
NT-I7 preferentially expands PD-1+TCF1+Tim-3- stem-like virus-specific CD8 T cells rather than effector/TD subsets during chronic LCMV infection
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Has reproduction · 58
Intergenic risk variant rs56258221 skews the fate of naive CD4(+) T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis.
PMID 38901430 · PMC11293351 · Cell reports. Medicine · 2024 · 8 claims · 8 setups
rs56258221 (BACH2/MIR4464) associates with a distinct peripheral blood T cell immunophenotype in people with PSC
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Has reproduction · 48
Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.
PMID 41933175 · PMC13052164 · Nature metabolism · 2026 · 8 claims · 8 setups
Irisin modulates adipose tissue inflammation by increasing IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues, thereby improving obesity and glucose intolerance.
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Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade.
PMID 41593194 · PMC13004670 · Nature medicine · 2026 · 8 claims · 5 setups
PD-1 blockade induces tumor-specific IgG1+ plasma cell responses that complement cellular immunity and contribute to clinical benefit
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Early days: genomics and human responses to infection.
PMID 16679048 · PMC7108404 · Current opinion in microbiology · 2006 · 8 claims · 8 setups
DNA microarray-based transcript profiling of primate/human responses to infection has begun to yield new insights into host-pathogen interactions but is limited by unresolved methodological challenges.
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Reinvigorating COTL1(high) NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours.
PMID 41912896 · PMC13179135 · Nature cell biology · 2026 · 8 claims · 8 setups
A COTL1-high NK cell subset mediates immune checkpoint blockade responsiveness in tsMHC-I impaired tumours
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Dietary conjugated linoleic acid enhances resistance to Salmonella infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells.
PMID 41964110 · PMC13078244 · Gut microbes · 2026 · 8 claims · 12 setups
Dietary CLA supplementation enhances host resistance to Salmonella Typhimurium infection
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Has reproduction · 67
HArmonized single-cell RNA-seq Cell type Assisted Deconvolution (HASCAD).
PMID 37907883 · PMC10619225 · BMC medical genomics · 2023 · 6 claims · 4 setups
Removal of batch effects in reference scRNA-seq datasets (via Harmony-Symphony) benefits the task of cell composition deconvolution
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Has reproduction · 71
Utilizing the codon adaptation index to evaluate the susceptibility to HIV-1 and SARS-CoV-2 related coronaviruses in possible target cells in humans.
PMID 36760235 · PMC9905242 · Frontiers in cellular and infection microbiology · 2022 · 8 claims · 8 setups
CAI is positively correlated with translational efficiency, validating its use as a proxy for translational efficiency at the elongation level.
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Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma.
PMID 41923620 · PMC13130624 · Cell reports. Medicine · 2026 · 7 claims · 8 setups
G9a expression inversely correlates with gene signatures predictive of favorable ICI response across multiple HCC patient cohorts