Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 19

System / cell line: lung ✕ Assay: cd8 ✕ Clear

The Ly6g(high) Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8(+) T Cell Death.

PMID 41625479 · PMC12857760 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups

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Neutrophils in the lung metastatic niche comprise two functionally distinct subsets, Ly6g^high and Ly6g^low, based on Ly6g expression level

lung cramp cd8+ neutrophils single-cell flow genetic
Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

PMID 37572656 · PMC10576612 · Immunity · 2023 · 8 claims · 8 setups

Has reproduction · 68

Arg1 is highly and specifically induced in lung CD4+ T cells during in vivo influenza infection

flow-sort-purified lung cd4+ congenically rna-seq flow expression
Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells.

PMID 42008567 · PMC13128127 · PLoS pathogens · 2026 · 9 claims · 9 setups

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Expansion of endogenous MCMV-specific CD8 T cells is delayed in early life due to a low precursor frequency of peripheral αβ T cells

peripheral spleen polyclonal neonatal pmhc-i mhc-ii flow
Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

PMID 41639447 · PMC12935554 · Nature · 2026 · 8 claims · 8 setups

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Lung adenocarcinoma (LUAD) induces increased innervation and functional/transcriptional engagement of vagal sensory neurons (VSNs)

kras-g12d tumour-bearing vagal npy2r-ires-cre whole-mount aav neurite
ZFP148 is a transcriptional repressor of cytolytic effector CD8(+) T cell differentiation.

PMID 41896465 · PMC13043298 · Nature immunology · 2026 · 8 claims · 8 setups

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ZFP148 is enriched in CD8+ T progenitor (T PRO) cells and its expression declines during differentiation into effector (T EFF) and exhausted (T EX) cells

p14 splenic cd8+ b16-gp scrna-seq flow tcr
Transient tumor exposure induces persistent functional defects in memory CD8(+) T cells.

PMID 42023146 · PMC13098610 · iScience · 2026 · 8 claims · 8 setups

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Memory CD8+ T cells generated after transient tumor rejection (Tum-CD8+) display a distinct, partially exhausted phenotype compared to virus-induced memory cells (Vir-CD8+)

cd45.1 single-cell memory ctv flow single-cell cytokine
Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7.

PMID 41920738 · PMC13222646 · Cell reports · 2026 · 8 claims · 8 setups

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NT-I7 preferentially expands PD-1+TCF1+Tim-3- stem-like virus-specific CD8 T cells rather than effector/TD subsets during chronic LCMV infection

chronic chronically lcmv-specific spleen flow ki67 intracellular
Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

PMID 41533733 · PMC12829949 · PLoS pathogens · 2026 · 8 claims · 8 setups

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Aged Nr4a3-Tocky mice develop more severe pneumonia and delayed body weight recovery after SARS-CoV-2 infection than adult mice

nr4a3-tocky bronchoalveolar lung left viral histopathology immunohistochemistry
Analysis of Tumor-Infiltrating T-Cell Transcriptomes Reveal a Unique Genetic Signature across Different Types of Cancer.

PMID 36232369 · PMC9569723 · International journal of molecular sciences · 2022 · 8 claims · 8 setups

Has reproduction · 87

Common genes shared across five cancer types differ from those found in nonmalignant tissue-resident T-cells for each subset (CD4-T, CD8-T, Treg)

breast lung colorectal melanoma single-cell gene reactome
Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

PMID 41810957 · PMC13059739 · mBio · 2026 · 8 claims · 8 setups

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IFN-γ signaling in T cells contributes to the development of malaria-associated lung pathology

lungs pbnk65-infected cell-specific lung flow time-series qrt-pcr
The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8(+) T cells.

PMID 41851343 · PMC13121605 · EMBO reports · 2026 · 8 claims · 8 setups

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Progressive expression of KLRB1, KLRG1, GPR56, and KLRF1 tracks CD8+ T cell differentiation stages (TN, TCM, TEM, TEMRA), mirroring the pattern previously shown in CD4+ T cells

unstimulated cd3+-enriched enriched cd8+ flow sorting-based spatial
DLX2 marks an immunosuppressive dendritic-cell program that reshapes cytotoxic immunity and marks a tolerogenic microenvironment in lung adenocarcinoma.

PMID 41761000 · PMC13043845 · Discover oncology · 2026 · 8 claims · 8 setups

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Neuroactive ligand–receptor signaling is among the most significantly upregulated pathways in LUAD relative to normal lung tissue.

tcga-luad tcga luad dendritic-cell bulk survival pan-cancer
Ionizing Radiation Enhances Prognostically Significant Cellular Immunity Programs in the Brain Metastasis Microenvironment.

PMID 41817317 · PMC13223553 · Clinical cancer research : an official journal of the American Association for Cancer Research · 2026 · 8 claims · 7 setups

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High-grade histopathologic TIL infiltration is associated with significantly prolonged overall survival in breast and lung cancer BM.

breast lung histopathologic sequencing tcr
The Presence of CD11c+ B Cells with Potent Effector Memory Phenotype in Lung Adenocarcinoma Correlates with Overall Patient Survival.

PMID 41686183 · PMC12988592 · Cancer immunology research · 2026 · 7 claims · 7 setups

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CD79A is a reliable transcriptomic/protein quantifier of B lymphocytes across differentiation stages, unlike CD19/CD20 whose expression changes upon activation

healthy tcga luad til-b flow bulk single-cell
Ectopic CD11c Drives SMAD3-Mediated Aberrant Antigen Presentation and Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma.

PMID 41799568 · PMC12963642 · Cancer communications (London, England) · 2026 · 8 claims · 13 setups

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An ESCC epithelial cell subcluster with ectopic CD11c (ITGAX) expression, found in both mice and humans, exhibits concurrent impaired antigen presentation and EMT phenotypes

4-nqo-induced escc esophageal lung multiplex flow whole-genome
Quemliclustat and chemotherapy with or without zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial.

PMID 41912809 · PMC13099643 · Nature medicine · 2026 · 7 claims · 8 setups

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Quemliclustat combined with gemcitabine/nab-paclitaxel (G/nP) with or without zimberelimab has a safety profile consistent with G/nP alone across dose-escalation and dose-expansion phases

mia hct-116 patients randomized rna-seq rt-pcr phase
Utilizing the codon adaptation index to evaluate the susceptibility to HIV-1 and SARS-CoV-2 related coronaviruses in possible target cells in humans.

PMID 36760235 · PMC9905242 · Frontiers in cellular and infection microbiology · 2022 · 8 claims · 8 setups

Has reproduction · 71

CAI is positively correlated with translational efficiency, validating its use as a proxy for translational efficiency at the elongation level.

unstimulated cd4+ kidney liver bulk single-cell
Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome.

PMID 41956098 · PMC7619149 · Immunity · 2026 · 8 claims · 8 setups

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Reduced NMD activity (lower NMD score) predicts improved CPI response across >1,000 patients, independent of TMB or tumor type

tcga a375 reporter patient-derived multi-omics crispr-cas9 sirna
Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion.

PMID 19097825 · PMC2692687 · Clinical immunology (Orlando, Fla.) · 2009 · 8 claims · 7 setups

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CORO1A deficiency, caused by a paternal 2bp frameshift mutation combined with a maternal de novo 600kb deletion at chromosome 16p11.2, is the molecular cause of this patient's T-B+NK+ SCID

ebv-transformed genomic father peripheral intracellular snp sequencing

Experiments

The Ly6g(high) Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8(+) T Cell Death.

Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.

Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells.

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

ZFP148 is a transcriptional repressor of cytolytic effector CD8(+) T cell differentiation.

Transient tumor exposure induces persistent functional defects in memory CD8(+) T cells.

Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7.

Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

Analysis of Tumor-Infiltrating T-Cell Transcriptomes Reveal a Unique Genetic Signature across Different Types of Cancer.

Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8(+) T cells.

DLX2 marks an immunosuppressive dendritic-cell program that reshapes cytotoxic immunity and marks a tolerogenic microenvironment in lung adenocarcinoma.

Ionizing Radiation Enhances Prognostically Significant Cellular Immunity Programs in the Brain Metastasis Microenvironment.

The Presence of CD11c+ B Cells with Potent Effector Memory Phenotype in Lung Adenocarcinoma Correlates with Overall Patient Survival.

Ectopic CD11c Drives SMAD3-Mediated Aberrant Antigen Presentation and Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma.

Quemliclustat and chemotherapy with or without zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial.

Utilizing the codon adaptation index to evaluate the susceptibility to HIV-1 and SARS-CoV-2 related coronaviruses in possible target cells in humans.

Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome.

Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion.