Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 13

System / cell line: microarray ✕ Assay: cd8 ✕ Clear

Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes.

PMID 18267303 · PMC5054231 · Genomics, proteomics & bioinformatics · 2007 · 8 claims · 8 setups

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Gene expression of INSR, VDR, IDE, Akt, IRS-1, IRS-2, GLUT4, and glycolytic pathway enzymes is decreased at least 50% in T2DM muscle and activated T-cells versus non-diabetic controls

activated skeletal muscle altered affymetrix quantitative sirna
Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.

PMID 41673882 · PMC13047816 · Journal of orthopaedic surgery and research · 2026 · 8 claims · 8 setups

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Effector CD8+ memory T (Tem) cells are significantly elevated in AS patients compared to healthy controls

bone peripheral effector interspinous single-cell cibersortx cell-cell
TOPK Suppresses the CD8(+) T Cell Antitumor Immunity via Modulation of IRF5 Expression.

PMID 41868885 · PMC13003159 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups

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A TOPK+ subset of tumor-infiltrating CD8+ T cells exists in melanoma at higher frequency than in normal lymph nodes and shows suppressed cytotoxic/cytokine programs.

tumor-infiltrating melanoma b16-f10 unspecified scrna-seq flow multiplex
Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.

PMID 26538066 · PMC4634735 · BMC medical genomics · 2015 · 8 claims · 7 setups

Has reproduction · 83

A multigene expression biomarker from PBMCs accurately classifies familial breast cancer (FBC) status

pbmcs utah blood normal microarray svm-rfe svm
Comprehensive Analysis of Cell Population Dynamics and Related Core Genes During Vitiligo Development.

PMID 33679890 · PMC7933673 · Frontiers in genetics · 2021 · 8 claims · 7 setups

Has reproduction · 67

Immune cell infiltration and abnormal gene expression are closely related to vitiligo pathogenesis

skin peripheral vitiligo deg gene immune coexpression
Early days: genomics and human responses to infection.

PMID 16679048 · PMC7108404 · Current opinion in microbiology · 2006 · 8 claims · 8 setups

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DNA microarray-based transcript profiling of primate/human responses to infection has begun to yield new insights into host-pathogen interactions but is limited by unresolved methodological challenges.

peripheral liver gastric brain microarray
IRSN-23 gene diagnosis enhances breast cancer subtype classification and predicts response to neoadjuvant chemotherapy: new validation analyses.

PMID 40128415 · PMC11993443 · Breast cancer (Tokyo, Japan) · 2025 · 8 claims · 8 setups

Has reproduction · 71

IRSN-23 Gp-R patients have significantly higher pCR rates than Gp-NR patients without anti-HER2 therapy, across the OUH cohort and multiple independent public datasets

breast microarray rna-seq exome
Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines.

PMID 41811958 · PMC12978219 · Science advances · 2026 · 6 claims · 7 setups

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An integrated pipeline combining ML-based epitope prediction (netMHCpan, EpiDope, BepiPred), TCRpMHC structural modeling/docking, and JessEV vaccine design can prioritize viral peptides by immunogenicity, allele coverage, solubility, and stability.

preexposed alphaviral peptide-hla modeled peptide epitope structural
Elucidating the Prognostic and Therapeutic Implications of Insulin Resistance Genes in Breast Cancer: A Machine Learning-Powered Analysis.

PMID 40427728 · PMC12109394 · Biology · 2025 · 8 claims · 8 setups

Has reproduction · 84

A seven-gene IRG prognostic signature (LIFR, EZR, TBC1D4, NSF, RPL5, SAA1, PGK1) predicts overall survival in breast cancer across training and four validation cohorts

tcga-brca triple-negative ffpe bulk univariate kaplan-meier
Dissecting glioblastoma risk signatures in the tumor immune microenvironment based on multi-dimensional transcriptomics.

PMID 41880523 · PMC13154832 · GigaScience · 2026 · 7 claims · 8 setups

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Hallmarks of malignancy and cell cycle regulatory pathways are consistently enriched across single-cell, bulk, and spatial transcriptomic modalities, promoting tumor cell proliferation and progression.

tumor gbm normal wild-type single-cell bulk microarray
VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity.

PMID 41776161 · PMC13194722 · Nature communications · 2026 · 8 claims · 8 setups

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VISTA deficiency significantly impairs PDAC tumor growth and prolongs survival in murine orthotopic models

pan02 cd45+ tumor mice orthotopic pharmacological flow
Machine learning-based identification of an immunotherapy-related signature to enhance outcomes and immunotherapy responses in melanoma.

PMID 39355255 · PMC11442245 · Frontiers in immunology · 2024 · 8 claims · 8 setups

Has reproduction · 69

66 consensus immunotherapy prognostic genes (CITPGs) were identified from the intersection of WGCNA modules, immunotherapy responder-vs-non-responder DEGs, and tumor-vs-normal DEGs

melanoma tcga-skcm prjeb23709 microarray wgcna differential consensus
Multi-Omic Profiling of T Cell-Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance.

PMID 41467897 · PMC12752722 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · 8 claims · 8 setups

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The BCR repertoire, particularly the IgG isotype, is significantly expanded in TCMR compared to stable renal function (STA) across independent renal transplant cohorts

kidney healthy lp-1 bcr bulk triple

Experiments

Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes.

Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.

TOPK Suppresses the CD8(+) T Cell Antitumor Immunity via Modulation of IRF5 Expression.

Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.

Comprehensive Analysis of Cell Population Dynamics and Related Core Genes During Vitiligo Development.

Early days: genomics and human responses to infection.

IRSN-23 gene diagnosis enhances breast cancer subtype classification and predicts response to neoadjuvant chemotherapy: new validation analyses.

Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines.

Elucidating the Prognostic and Therapeutic Implications of Insulin Resistance Genes in Breast Cancer: A Machine Learning-Powered Analysis.

Dissecting glioblastoma risk signatures in the tumor immune microenvironment based on multi-dimensional transcriptomics.

VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity.

Machine learning-based identification of an immunotherapy-related signature to enhance outcomes and immunotherapy responses in melanoma.

Multi-Omic Profiling of T Cell-Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance.