Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Clonal CD8(+) T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases.

  PMID 41593242 · PMC12864034 · Nature immunology · 2026 · 8 claims · 6 setups

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  The human leptomeninges harbor substantial numbers of clonally expanded, tissue-resident memory CD8 T cells (ZNF683-high, CXCR6+, PD-1+)

  postmortem leptomeninges scrna-seq-derived leptomeningeal single-cell flow imaging

• TOPK Suppresses the CD8(+) T Cell Antitumor Immunity via Modulation of IRF5 Expression.

  PMID 41868885 · PMC13003159 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups

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  A TOPK+ subset of tumor-infiltrating CD8+ T cells exists in melanoma at higher frequency than in normal lymph nodes and shows suppressed cytotoxic/cytokine programs.

  tumor-infiltrating melanoma b16-f10 unspecified scrna-seq flow multiplex

• Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells.

  PMID 42008567 · PMC13128127 · PLoS pathogens · 2026 · 9 claims · 9 setups

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  Expansion of endogenous MCMV-specific CD8 T cells is delayed in early life due to a low precursor frequency of peripheral αβ T cells

  peripheral spleen polyclonal neonatal pmhc-i mhc-ii flow

• Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8(+) T cells.

  PMID 37081150 · PMC10154250 · Nature immunology · 2023 · 8 claims · 7 setups

  Has reproduction · 37

  Orthogonal engineering with PD1d/IL-2v/IL-33 reprograms adoptively transferred CD8+ T cells into a novel synthetic effector state (C5/TSE) that deviates from canonical TOX+ exhaustion

  cd8+ b16-ova ot1 mice scrna-seq flow secretion

• Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection.

  PMID 36450262 · PMC9792173 · Cell reports · 2022 · 8 claims · 6 setups

  Has reproduction · 50

  IL-21-producing Tfh CD4 T cells repopulate after CD4 depletion but remain at reduced frequency compared with control mice

  cd44+ splenocytes spleen tcr scrna-seq flow spatial

• CLK1 Promotes Myeloid-Derived Suppressor Cell Trafficking and Reprograms the Tumor Microenvironment by Activating Hippo/YAP Signaling in Colorectal Cancer.

  PMID 41686262 · PMC13136879 · Cancer immunology research · 2026 · 8 claims · 8 setups

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  CLK1 is markedly upregulated in immune-cold colorectal tumors and correlates with increased MDSC infiltration and CD8+ T-cell exclusion

  colorectal tcga-coad ct26 tumor scrna-seq bulk multiplex

• Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes.

  PMID 41800251 · PMC12965062 · International journal of biological sciences · 2026 · 8 claims · 8 setups

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  TMZ enhances mitochondrial membrane potential and suppresses fatty acid oxidation (FAO) in human T cells

  peripheral endoc-βh5 nod pancreatic mitochondrial extracellular glucose-stimulated

• Spatial transcriptomics unveils immune cellular ecosystems associated with patient survival in diffuse large B-cell lymphoma.

  PMID 42010788 · PMC13102037 · Oncoimmunology · 2026 · 7 claims · 7 setups

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  DLBCL tissues are organized into six recurrent, spatially defined cellular ecosystems (Cell-Eco) with distinct immune compositions, transcriptional programs, and neighborhood architectures.

  dlbcl cd45+ spots scrna-seq spatial scrna-seq cell-type

• VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity.

  PMID 41776161 · PMC13194722 · Nature communications · 2026 · 8 claims · 8 setups

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  VISTA deficiency significantly impairs PDAC tumor growth and prolongs survival in murine orthotopic models

  pan02 cd45+ tumor mice orthotopic pharmacological flow

• Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

  PMID 41810957 · PMC13059739 · mBio · 2026 · 8 claims · 8 setups

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  IFN-γ signaling in T cells contributes to the development of malaria-associated lung pathology

  lungs pbnk65-infected cell-specific lung flow time-series qrt-pcr

• Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging.

  PMID 42010880 · PMC13096584 · Aging cell · 2026 · 8 claims · 8 setups

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  T cells are the immune cell population with the most pronounced transcriptomic alterations during liver aging

  liver nash cirrhotic hcc scrna-seq snrna-seq stereo-seq

• Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.

  PMID 41735308 · PMC13043769 · Nature communications · 2026 · 8 claims · 8 setups

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  OSGEP is the catalytic subunit of the KEOPS complex responsible for t6A modification at position 37 of cytoplasmic tRNAs, and its loss causes the highest protein aggregation among 45 screened tRNA-modifying enzymes in melanoma cells

  mm117 b16f10 b16f10-derived c57bl esirna shrna rna-seq

• A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells.

  PMID 41484771 · PMC12882460 · Molecular cancer · 2026 · 7 claims · 5 setups

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  Integration of pan-cancer scRNA-seq data yields a comprehensive single-cell atlas of 157,025 high-quality DNT cells across 23 cancer types.

  tumor dnt ffpe mc38 scrna-seq tcr multiplex

• Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

  PMID 41533733 · PMC12829949 · PLoS pathogens · 2026 · 8 claims · 8 setups

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  Aged Nr4a3-Tocky mice develop more severe pneumonia and delayed body weight recovery after SARS-CoV-2 infection than adult mice

  nr4a3-tocky bronchoalveolar lung left viral histopathology immunohistochemistry

• Single-Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys.

  PMID 41556329 · PMC13042567 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 7 claims · 8 setups

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  GZMB is markedly upregulated across multiple cell types in aged rhesus monkeys and serves as a candidate biomarker of immunosenescence

  bone cd8+ mesenteric sections single-cell gene pseudotime

• A pan-cancer single-cell transcriptomic atlas of human bone metastases.

  PMID 41619722 · PMC12923970 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  Constructed a pan-cancer single-cell transcriptomic atlas of 62 human bone metastases (predominantly spinal) across 13 primary cancer types, with paired primary tumor and normal bone marrow samples.

  bone paired plasmacytoma malignant scrna-seq ihc infercnv

• CEBPB-Regulated Gastric Cell Plasticity Promotes Liver Metastasis of Gastric Cancer.

  PMID 41836678 · PMC12981248 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups

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  GC cells undergoing liver metastasis transcriptionally reprogram into a high-plasticity cell state

  tumor lines nci-n87 balb single-cell epigenomics transwell

• Dietary conjugated linoleic acid enhances resistance to Salmonella infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells.

  PMID 41964110 · PMC13078244 · Gut microbes · 2026 · 8 claims · 12 setups

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  Dietary CLA supplementation enhances host resistance to Salmonella Typhimurium infection

  ileal mice serum culture 16s untargeted bulk

• Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression.

  PMID 41997138 · PMC13213619 · Cancer cell · 2026 · 8 claims · 8 setups

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  A novel proliferative Treg precursor state, cycling Treg (cycTreg: FOXP3^int, MKI67^hi, IKZF2/4^int-hi), is absent in normal breast, low in DCIS, and strongly expanded in IBC

  normal mammary dcis tumor-draining scrna-seq spatial multiplex

• DLX2 marks an immunosuppressive dendritic-cell program that reshapes cytotoxic immunity and marks a tolerogenic microenvironment in lung adenocarcinoma.

  PMID 41761000 · PMC13043845 · Discover oncology · 2026 · 8 claims · 8 setups

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  Neuroactive ligand–receptor signaling is among the most significantly upregulated pathways in LUAD relative to normal lung tissue.

  tcga-luad tcga luad dendritic-cell bulk survival pan-cancer