Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Reconstructing transcriptional regulatory networks through genomics data.
PMID 20048387 · PMC3666560 · Statistical methods in medical research · 2009 · 7 claims · 5 setups
Location data (ChIP-chip/ChIP-seq) alone is insufficient for TRN inference because binding does not imply regulation, TF binding is dynamic across conditions/time, and TRNs involve combinatorial effects of multiple TFs not captured by single-TF ChIP experiments.
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Prior-guided factorization for reliable imputation of scRNA-seq data.
PMID 41860953 · PMC13004523 · PLoS computational biology · 2026 · 8 claims · 8 setups
scZN models scRNA-seq counts as a mixture of a two-state (Gamma-Poisson/negative binomial) transcriptional bursting process and dropout, formalized via a zero-inflated negative binomial (ZINB) and solved as constrained nonnegative matrix factorization into a cell-to-cell-type assignment matrix and a cell-type expression matrix