Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Mitochondrial DNA methylation predicts immunotherapy response and prognosis in lung adenocarcinoma: evidence from scRNA-Seq and machine learning.
PMID 41663976 · PMC12997902 · BMC cancer · 2026 · 8 claims · 8 setups
Differentially expressed MTDM-related genes (DEMTDMRGs) are significantly enriched in cell cycle regulation, ferroptosis, and ABC transporter pathways
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Targeting KIFC1 to disrupt centrosome clustering and trigger anaphase catastrophe in small-cell lung cancer.
PMID 41948931 · PMC13134724 · JCI insight · 2026 · 8 claims · 8 setups
KIFC1 is overexpressed in SCLC compared with normal tissues and other cancer types
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Locus-specific and activity-independent gene repositioning during early tumorigenesis.
PMID 18195100 · PMC2213600 · The Journal of cell biology · 2008 · 7 claims · 6 setups
The genome undergoes global spatial reorganization during both normal and tumorigenic mammary epithelial differentiation, as shown by reduced nucleolar number.
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UBE2M as a bridge spanning neddylation and cell cycle regulation in colorectal adenocarcinoma.
PMID 41680469 · PMC12993059 · Experimental & molecular medicine · 2026 · 8 claims · 8 setups
Neddylation is associated with G2M phase progression in CRC
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A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer.
PMID 42097145 · PMC13198260 · Cell reports. Medicine · 2026 · 8 claims · 7 setups
A distinct NOTUM/NKD1/APCDD1-high, WNT-inhibitory cancer cell population (WICC) emerges predominantly in advanced-stage MSS CRC
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Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression.
PMID 16083501 · PMC1208945 · Molecular cancer · 2005 · 8 claims · 8 setups
Restoration of TSLC1 expression in A549 cells (yielding the 12.2 line) suppresses tumorigenic growth, markedly reducing cell expansion/proliferation rate.
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NELF prevents transcriptional readthrough into DNA replication zones in cancer cells.
PMID 41721097 · PMC13076867 · EMBO reports · 2026 · 8 claims · 8 setups
NELFCD transcript and NELF subunit protein levels are significantly upregulated in colorectal tumors (COAD/READ) relative to normal tissue
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Has reproduction · 100
Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma.
PMID 35893303 · PMC9329910 · Journal of personalized medicine · 2022 · 8 claims · 8 setups
Oncogenes MITF, KIT, CDH1, NRAS, AKT1, EGFR, TP53, and CDK4 are elevated while tumor suppressors PTEN, cAMP, and BCL2 are reduced in melanoma
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Functional role of the KLF6 tumour suppressor gene in gastric cancer.
PMID 19101139 · PMC2970616 · European journal of cancer (Oxford, England : 1990) · 2009 · 7 claims · 8 setups
The KLF6 locus undergoes loss of heterozygosity (LOH) in a majority of gastric cancer samples and is associated with advanced tumour stage
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Has reproduction · 59
Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma.
PMID 39057099 · PMC11276454 · Current issues in molecular biology · 2024 · 8 claims · 8 setups
PTBP1 is significantly upregulated across multiple cancer types including LUAD, and higher PTBP1 levels are associated with worse LUAD patient survival
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Defining disease with laser precision: laser capture microdissection in gastroenterology.
PMID 18619446 · PMC3736118 · Gastroenterology · 2008 · 8 claims · 8 setups
LCM allows isolation of pure cell populations from heterogeneous tissue without damaging DNA, RNA, or protein integrity.
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Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.
PMID 41680858 · PMC12910993 · Journal of translational medicine · 2026 · 8 claims · 8 setups
IL4I1 mRNA expression is significantly elevated in AML compared to normal controls
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VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.
PMID 41820368 · PMC13121600 · Nature communications · 2026 · 8 claims · 8 setups
CBFB (CBF-β) is a synthetic lethal interactor of VHL in ccRCC cell lines
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Has reproduction · 89
Inference of Subpathway Activity Profiles Reveals Metabolism Abnormal Subpathway Regions in Glioblastoma Multiforme.
PMID 33072547 · PMC7533644 · Frontiers in oncology · 2020 · 8 claims · 7 setups
A GSVA-based method for constructing a metabolic subpathway activity score matrix accurately identifies abnormal GBM metabolic targets
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Current and future directions in genomics of amyotrophic lateral sclerosis.
PMID 18625410 · PMC3524513 · Physical medicine and rehabilitation clinics of North America · 2008 · 8 claims · 8 setups
Familial ALS (FALS, 5-10% of cases) follows Mendelian autosomal dominant inheritance, with 20% caused by SOD1 mutations and 80% by unknown mutations
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Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF-β/Smad3 Signaling.
PMID 41486854 · PMC12915081 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups
ANXA13 is selectively downregulated in the kidneys of AKI patients and IRI- or cisplatin-induced AKI mice, primarily in proximal tubular cells