Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Cell-Type-Specific Gene Modules Related to the Regional Homogeneity of Spontaneous Brain Activity and Their Associations With Common Brain Disorders.

  PMID 33958982 · PMC8093778 · Frontiers in neuroscience · 2021 · 8 claims · 6 setups

  Has reproduction · 59

  Fourteen gene modules were consistently (Bonferroni-corrected) associated with ReHo across a discovery sample and two independent replication samples (including one non-Chinese HCP cohort).

  healthy postmortem ahba neocortex resting-state microarray weighted

• Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury.

  PMID 41926211 · PMC13262727 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  Aged TBI brains predominantly harbor proinflammatory NLRP3+ microglia, whereas young TBI brains harbor neuroprotective Lysozyme+ microglia

  injured sorted facs-purified cas9-gfp scrna-seq atac-seq untargeted

• MECP2 mutations rewire human ESC fate and bias cortical lineage commitment.

  PMID 42030940 · PMC13163216 · Stem cell reports · 2026 · 8 claims · 8 setups

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  MECP2 mutations induce an early naïve-like transcriptional drift in human ESCs, marked by upregulation of ZFP42/REX1 and other naïve-enriched markers

  isogenic undifferentiated 3-month bulk bulk single-cell single-nucleus

• Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation.

  PMID 41851525 · PMC13132723 · Nature immunology · 2026 · 8 claims · 8 setups

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  Microglia repopulate rapidly and exclusively cell-autonomously from surviving microglia after CSF-1R inhibitor (BLZ945) depletion.

  brain cerebral cd11b+cd45int-hi leptomeninges flow confocal single-cell

• SpaNiche: spatial niche analysis to explore colocalization patterns and cellular interactions in spatial transcriptomics data.

  PMID 42015285 · PMC13231777 · Genome biology · 2026 · 8 claims · 6 setups

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  SpaNiche integrates smoothed cell-type abundance and ligand-receptor expression matrices via graph-regularized joint NMF, across multiple spatial views, to identify colocalization patterns

  lymph colorectal prostate cerebral simulated spatial scrna-seq

• Charting and probing the activity of ADARs in human development and cell-fate specification.

  PMID 39537590 · PMC11561244 · Nature communications · 2024 · 8 claims · 6 setups

  Has reproduction · 100

  RNA editing (AEI) and ADAR/ADARB1/ADARB2 expression show organ-specific dynamic shifts across fetal-to-adult developmental stages in human forebrain, hindbrain, heart, liver, kidney, and testis

  organ same 8-week-old week alu site-specific gene

• Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination.

  PMID 41896238 · PMC13260908 · Nature communications · 2026 · 8 claims · 8 setups

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  Bhlhe41 is microglia-enriched in the CNS and is negatively autoregulated (self-repressed) at its own promoter.

  yolk microglia cerebral enriched sequencing flow western