Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma.

  PMID 41923630 · PMC13130666 · Cell reports. Medicine · 2026 · 8 claims · 4 setups

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  A malignant cell subset expressing IFN-response and MHC-II genes (IFN/MHC-II) increases in proportion after pembrolizumab treatment and is associated with response

  hnscc ffpe syngeneic independent single-cell multiplexed tumor

• Pre-existing cell states predict resistance to multiple treatments.

  PMID 41916275 · PMC13261651 · Cell genomics · 2026 · 8 claims · 5 setups

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  Rare melanoma clones can develop resistance to multiple diverse treatments simultaneously, not just single treatments

  wm989 time-lapse barcode single-cell

• PD-1 blockade plus tyrosine kinase inhibitor remodels the tumor microenvironment in advanced renal cell carcinoma.

  PMID 41916996 · PMC13199584 · Nature communications · 2026 · 8 claims · 8 setups

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  Non-responders to TKI±ICI therapy show increased neutrophil infiltration and enrichment of SAA+ tumor cells after treatment.

  arcc pre post-treatment tumor single-cell multiplex ligand-receptor

• PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.

  PMID 41556358 · PMC13042517 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  A PRDM1+ malignant epithelial cell subcluster (Epi_C4) is enriched in NMPR patients and is associated with nICRT treatment resistance

  locally escc pd-1 kyse-30 single-arm scrna-seq bulk

• Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy.

  PMID 41820396 · PMC13121706 · Nature communications · 2026 · 8 claims · 7 setups

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  TRIM, a conditional multi-modal variational autoencoder integrating paired scRNAseq and scTCRseq data, predicts T cell clonality and transcriptional states at unmeasured tissue sites/timepoints.

  hnscc colorectal pan-cancer tcr paired umap convolutional

• Müller glial and microglial responses coupled to recovery of cone photoreceptors following limited cone ablation in zebrafish retina.

  PMID 41691075 · PMC12992573 · Scientific reports · 2026 · 7 claims · 6 setups

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  24-hour 10mM Mtz immersion of adult gnat2:nfsb-mCherry zebrafish causes death of only a limited number of cone photoreceptors rather than widespread ablation

  retinal retina dissociated live tunel immunofluorescence rt-qpcr