Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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PReMod: a database of genome-wide mammalian cis-regulatory module predictions.
PMID 17148480 · PMC1761432 · Nucleic acids research · 2007 · 8 claims · 3 setups
PReMod is a database of genome-wide predicted cis-regulatory modules (pCRMs) for the human and mouse genomes.
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CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators.
PMID 17981843 · PMC2238977 · Nucleic acids research · 2008 · 7 claims · 8 setups
CTCF is the only identified trans-acting factor in vertebrates that confers enhancer-blocking insulator activity
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Systems biology of gene regulation fulfills its promise.
PMID 16719937 · PMC1779525 · Genome biology · 2006 · 8 claims · 8 setups
Suz12, a Polycomb Group complex component, has DNA targets identifiable by ChIP-chip and can silence large genomic regions in a cell-type-specific manner.
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Identifying cis-regulatory sequences by word profile similarity.
PMID 19730735 · PMC2731932 · PloS one · 2009 · 8 claims · 8 setups
WPH-finder identifies putative co-regulated CRMs by scanning the genome for sequences with word profiles similar to a known CRM, without explicitly defining binding sites
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The integrated world of functional genomics.
PMID 12537543 · PMC151279 · Genome biology · 2003 · 8 claims · 8 setups
Integrating chromatin immunoprecipitation (promoter-binding) data with expression data reveals the yeast cell-cycle transcriptional regulatory network, including network motifs such as autoregulation, multi-component loops, and feedforward loops.
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Adaptively inferring human transcriptional subnetworks.
PMID 16760900 · PMC1681499 · Molecular systems biology · 2006 · 8 claims · 7 setups
A multivariate linear spline (MARS-based) model correlating PWM binding scores with log expression ratios can identify active cis-motif combinations in mammalian promoters without requiring gene clustering.
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Biocomputing enters its adolescence.
PMID 15960815 · PMC1175967 · Genome biology · 2005 · 8 claims · 8 setups
A 'match augmentation' algorithm efficiently matches structural motifs by prioritizing functionally significant residues, enabling function prediction between evolutionarily unrelated proteins
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In silico meets in vivo.
PMID 18304380 · PMC2374716 · Genome biology · 2008 · 8 claims · 8 setups
About 10% of positions in multiple sequence alignments of the human genome with other vertebrate genomes are likely incorrect.