Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Modeling ChIP sequencing in silico with applications.

  PMID 18725927 · PMC2507756 · PLoS computational biology · 2008 · 8 claims · 4 setups

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  Observed ChIP-seq tag counts follow an initial power-law distribution followed by a long right tail.

  stat1 ncbi chip-seq motif

• Transcriptional landscape of repetitive elements in normal and cancer human cells.

  PMID 25012247 · PMC4122776 · BMC genomics · 2014 · 8 claims · 8 setups

  Has reproduction · 76

  RepEnrich, a computational method that uses all mapping reads (uniquely mapping plus multi-mapping reads assigned to repetitive element subfamily assemblies/pseudogenomes), quantifies genome-wide repetitive element enrichment

  chromosomes lines imr-90 prostate simulated pol chip-seq

• Protocadherin 20 Is a POU Class 2 Homeobox 3 Target Gene Required for Proper Tuft Cell Microvillus Organization.

  PMID 41619969 · PMC13051935 · Cellular and molecular gastroenterology and hepatology · 2026 · 8 claims · 8 setups

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  POU2F3 ChIP-seq in isolated murine tuft cells identifies high-confidence POU2F3 binding sites/target genes enriched at gene promoters and the POU consensus motif

  facs-isolated pou2f3 duodenal non-small-cell chip-seq novo bulk

• AmalgaMo: flexible DNA motif merging.

  PMID 41768281 · PMC12947577 · Bioinformatics advances · 2026 · 7 claims · 7 setups

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  AmalgaMo is a flexible command-line tool for merging highly similar DNA/RNA motifs, using five tunable parameters (t, m, r, s, a), accepting HOCOMOCO/JASPAR/MEME/CisBP formats.

  hocomoco paired chip-seq atac-seq motif regression-based bulk

• Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding.

  PMID 41639407 · PMC12900649 · Nature genetics · 2026 · 8 claims · 8 setups

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  Acute HDAC inhibition (TSA pulse) induces genome-wide H3K27 hyperacetylation and reorganizes the histone modification landscape, shifting more of the genome to an active state.

  e14 simulated mescs calibrated atac-seq bulk

• Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.

  PMID 33397809 · PMC7826347 · Proceedings of the National Academy of Sciences of the United States of America · 2021 · 7 claims · 7 setups

  Has reproduction · 48

  An AD-specific frameshift insertion SNV in exon 27 of mouse PLCγ1 causes abnormal exon skipping (exons 26-30) during mRNA maturation in 5xFAD cortex

  cortex forebrain plcγ1 bulk rna-seq-based western

• High-throughput chromatin information enables accurate tissue-specific prediction of transcription factor binding sites.

  PMID 18988630 · PMC2662491 · Nucleic acids research · 2009 · 8 claims · 8 setups

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  Incorporating H3K4me3 chromatin modification estimates greatly improves the accuracy of in silico prediction of in vivo TF binding for a wide range of TFs in human and mouse

  embryonic neural t-cells mm8 chip-seq chip-chip pwm

• TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila.

  PMID 40314147 · PMC12774851 · Genetics · 2026 · 8 claims · 8 setups

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  TF2TG is an online resource integrating motif scan data, ChIP-seq peaks (modENCODE/modERN), Hi-C (TADs), REDfly-curated CRMs, ATAC-seq, protein-protein interaction data, and tissue-specific expression to predict TF-target gene relationships in Drosophila

  drosophila combined motif chip-seq whole-animal

• Substantial unannotated noncoding transcripts in tumors may transcriptionally regulate cancer-related genes.

  PMID 41606598 · PMC12924361 · BMC biology · 2026 · 8 claims · 8 setups

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  Many unannotated genes and transcripts (MSTRG/UNTs) are pervasively generated and significantly differentially expressed in cancer cell lines and tissues across four tumor types (lung, liver, stomach, colon)

  cancer a549 unt bulk chip-seq computational

• DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues.

  PMID 38600112 · PMC11006913 · Nature communications · 2024 · 8 claims · 5 setups

  Has reproduction · 93

  Many of the 92 assayed HD missense variants alter DNA binding affinity and/or specificity compared to their corresponding reference alleles

  homeodomain hoxd13 cerevisiae amino universal chip-seq electrophoretic

• Understanding the function of Pax5 in development of docetaxel-resistant neuroendocrine-like prostate cancers.

  PMID 39183332 · PMC11345443 · Cell death & disease · 2024 · 7 claims · 8 setups

  Has reproduction · 69

  Pax5 is an important transcription factor driving neuronal gene expression and is specific to t-NEPC

  ne-like prostate lucap mcrpc atac-seq acetylated-histone rna-seq

• Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites.

  PMID 36064968 · PMC9481459 · Nature cell biology · 2022 · 8 claims · 6 setups

  Has reproduction · 98

  Multi-target gRNAs (mgRNAs) can direct Cas9 to over a hundred well-mapped endogenous genomic sites simultaneously, enabling massively parallel, high-throughput interrogation of Cas9 activity via short-read sequencing

  hg38 hela hek293t induced genome-wide high-throughput chip-seq

• Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations.

  PMID 24782521 · PMC4066758 · Nucleic acids research · 2014 · 8 claims · 5 setups

  Has reproduction · 79

  EDD is a new algorithm that detects broad (megabase-size) enrichment domains from ChIP-seq data of widely distributed chromatin proteins such as A- and B-type lamins.

  normal dermal analysis set chip-seq chip-qpcr rna-seq

• High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface.

  PMID 25122613 · PMC4216921 · Genome research · 2014 · 8 claims · 7 setups

  Has reproduction · 87

  mRNA codon and amino acid pools are highly stable across mouse development and across tissues, simply reflecting the genomic background distribution of any possible transcriptome.

  c57bl strand-specific pol computational

• PPDPF is not a key regulator of human pancreas development.

  PMID 40193385 · PMC12037078 · PLoS genetics · 2025 · 8 claims · 8 setups

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  PPDPF is not a key regulator of human pancreas development, in contrast to its zebrafish orthologue exdpf

  fetuses fetal hesc population situ proteome qpcr

• Machine learning-predicted chromatin organization landscape across pediatric tumors.

  PMID 41904260 · PMC13039956 · Scientific reports · 2026 · 8 claims · 5 setups

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  SuPreMo-Akita (built on the Akita CNN) enables systematic in silico prediction of somatic SV effects on 3D genome folding across large SV cohorts where experimental testing is infeasible

  somatic per-sample tumor paired mutagenesis dimensionality h3k27ac

• ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

  PMID 22955991 · PMC3431496 · Genome research · 2012 · 8 claims · 8 setups

  Has reproduction · 74

  ENCODE/modENCODE define a set of working standards and guidelines for ChIP-seq covering antibody validation, experimental replication, sequencing depth, data/metadata reporting, and data quality assessment.

  small-genome nuclear whole-cell encode chip-seq chip-chip immunoblot

• Inference of RNA polymerase II transcription dynamics from chromatin immunoprecipitation time course data.

  PMID 24830797 · PMC4022483 · PLoS computational biology · 2014 · 8 claims · 8 setups

  Has reproduction · 75

  A convolved Gaussian process model of pol-II occupancy across gene segments captures the transcription wave and yields estimates of transcription speed and promoter-proximal pol-II activity.

  mcf7 promoter gene signals pol-ii clustering transcription

• A ligand-centered framework for γδ T cell activation in colorectal cancer revealed by single-cell and transformer-based perturbation.

  PMID 41607803 · PMC12835328 · Frontiers in immunology · 2025 · 8 claims · 8 setups

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  CRC-infiltrating γδ T cells show varied activation levels, with the TRM-like population being the major tumor-infiltrating subtype and exhibiting the lowest effector and exhaustion signature scores.

  crc-infiltrating crc scrna-seq gene nichenet

• Machine and Deep Learning Reveal Sequence Determinants Encoding Bivalent Histone Modifications.

  PMID 41946881 · PMC13057473 · Communications biology · 2026 · 8 claims · 7 setups

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  Bivalent domains have higher GC content and stronger evolutionary conservation than monovalent regions

  embryonic mesc random bivalent chip-seq rna-seq k-mer-based