Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 50
Dynamics and regulation of mitotic chromatin accessibility bookmarking at single-cell resolution.
PMID 36696508 · PMC9876548 · Science advances · 2023 · 7 claims · 8 setups
Chromatin accessibility continually decreases from mitotic entry until metaphase, then gradually increases as chromosomes segregate.
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Full-text index only
CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells.
PMID 41630911 · PMC12860730 · iScience · 2026 · 8 claims · 8 setups
CTCF and cohesin (RAD21) remain co-bound to DNA throughout interphase, including during the S (replication) phase, in HeLa cells
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Full-text index only
SOX2 phosphorylation during mitosis limits genomic damage.
PMID 41213799 · PMC12863253 · Genes & development · 2026 · 8 claims · 8 setups
SOX2 (but not SOX9) remains dynamically bound to mitotic chromatin throughout all mitotic stages in neural stem cells
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Has reproduction · 74
Effects of replication domains on genome-wide UV-induced DNA damage and repair.
PMID 36155646 · PMC9536635 · PLoS genetics · 2022 · 8 claims · 7 setups
Ongoing replication stimulates local nucleotide excision repair in both early and late replication domains as those regions become replicated
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Has reproduction · 90
Evolutionary repair: Changes in multiple functional modules allow meiotic cohesin to support mitosis.
PMID 32155147 · PMC7138332 · PLoS biology · 2020 · 8 claims · 7 setups
Replacing Scc1 with Rec8 in mitosis impairs sister chromosome cohesion, advances the timing of genome replication, and reduces reproductive fitness by 45%