Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Prediction of condition-specific regulatory genes using machine learning.

  PMID 32329779 · PMC7293043 · Nucleic acids research · 2020 · 8 claims · 6 setups

  Has reproduction · 85

  ConSReg integrates expression, DAP-seq TF-DNA binding, and ATAC-seq open chromatin data into machine learning models to predict condition-specific regulatory genes

  arabidopsis zea bulk dap-seq atac-seq

• 3D-super-enhancers are condensate-associated cis-regulatory communities.

  PMID 41797539 · PMC12968393 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  BOUQUET integrates genome topology, chromatin occupancy, and graph theory (label propagation) to assign CREs and transcription protein machinery to target genes and identify protein-rich 'communities' associated with condensates.

  embryonic mesc thymocytes chip-seq hichip single-cell

• Features affecting Cas9-induced editing efficiency and patterns in tomato: evidence from a large CRISPR dataset.

  PMID 41877594 · PMC13014117 · The Plant journal : for cell and molecular biology · 2026 · 8 claims · 5 setups

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  Chromatin accessibility significantly increases editing efficiency, with higher editing at targets in accessible versus inaccessible chromatin.

  tomato analysis using pcr mars-seq atac-seq

• Profiling the transcriptional regulatory network reveals putative shared regulatory elements within homoeologs in polyploid Brassica napus.

  PMID 41943068 · PMC13188692 · Genome biology · 2026 · 8 claims · 6 setups

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  38,068 REs were identified in B. napus seed tissue by integrating ATAC-seq (OCRs) and BS-seq (UMRs) data from four accessions

  seed napus identified genome-wide atac-seq bisulfite hi-c

• The changing face of genomics.

  PMID 15128443 · PMC416465 · Genome biology · 2004 · 8 claims · 8 setups

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  Genome-wide ChIP-chip mapping of ~200 yeast transcriptional regulators across environmental conditions reveals general principles of promoter architecture and regulatory response types

  yeast drosophila zebrafish elegans chip-chip comparative insertional

• From linear genome sequence to three-dimensional organization of the cell nucleus.

  PMID 12620101 · PMC153456 · Genome biology · 2003 · 8 claims · 8 setups

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  Chromosome conformation capture (3C) can quantify in vivo physical interaction frequencies between genomic loci by crosslinking, digestion, and intramolecular ligation followed by PCR

  saccharomyces mitotic nucleoplasm hela chromosome translocation stretched

• The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2.

  PMID 36627412 · PMC9832098 · Cellular and molecular life sciences : CMLS · 2023 · 8 claims · 8 setups

  Has reproduction · 59

  p27 restricts residual CDK activity after mitogen withdrawal to antagonize cell cycling, but is not essential for cell cycle exit per se

  sez-derived computational nsc npc atac-seq bulk lisa

• Putting proteins in one place.

  PMID 12790144 · PMC1316915 · Environmental health perspectives · 2003 · 8 claims · 7 setups

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  Rapamycin inhibits TOR, causing the silencing protein Sir3 to detach from chromatin at stress-response genes, triggering a coordinated multigene stress response that halts cancer cell proliferation

  saccharomyces yeast vascular skin chemical chromatin microarray

• Chromosome-scale genome assembly and annotation of the two-spotted cricket Gryllus bimaculatus (Orthoptera: Gryllidae).

  PMID 41678355 · PMC13042277 · G3 (Bethesda, Md.) · 2026 · 8 claims · 8 setups

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  A chromosome-scale genome assembly of the white-eyed mutant G. bimaculatus strain was generated using ONT + PacBio HiFi long reads integrated with Hi-C data

  bimaculatus nanopore pacbio hi-c

• A whole-genome assembly of St. Augustinegrass and visualizing diversity within the species.

  PMID 41873115 · PMC13009705 · The plant genome · 2026 · 7 claims · 7 setups

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  First chromosome-scale, phased haplotype genome assemblies of Stenotaphrum secundatum (cultivar Raleigh) were produced, anchored on nine chromosomes each

  stenotaphrum secundatum diploid long-read short-read hi-c

• Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.

  PMID 16061936 · PMC1182164 · Nucleic acids research · 2005 · 8 claims · 6 setups

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  Oct-1, Oct-2, PU.1, Sp1 and Sp3 interact in vitro with the pol gene HS7 region

  nuclear spodoptera hiv-infected nih3t3 electrophoretic supershift emsa

• CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators.

  PMID 17981843 · PMC2238977 · Nucleic acids research · 2008 · 7 claims · 8 setups

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  CTCF is the only identified trans-acting factor in vertebrates that confers enhancer-blocking insulator activity

  ohlsson ren zhao tissues chip-chip massive motif

• Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases.

  PMID 19763266 · PMC2740864 · PloS one · 2009 · 8 claims · 8 setups

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  Androgen treatment alters the whole-cell proteome of LNCaP prostate cancer cells

  lncap androgen prostate itraq mudpit immunoblot

• Protein microarray technology.

  PMID 17126887 · PMC1828913 · Mechanisms of ageing and development · 2007 · 8 claims · 8 setups

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  Protein microarrays enable high-throughput characterization of protein biochemical activities across an entire proteome in a single experiment

  yeast sh2 protein-protein protein-dna chromatin

• In silico meets in vivo.

  PMID 18304380 · PMC2374716 · Genome biology · 2008 · 8 claims · 8 setups

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  About 10% of positions in multiple sequence alignments of the human genome with other vertebrate genomes are likely incorrect.

  genome lines prokaryotic genomes genome genome-wide gene

• Deep-learning prediction of gene expression from personal genomes.

  PMID 41495833 · PMC12869966 · Genome biology · 2026 · 8 claims · 8 setups

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  Fine-tuning Enformer on paired personal WGS and RNA-seq data (Variformer) corrects Enformer's failure to predict inter-individual gene expression differences across held-out people.

  gtex rosmap same monocyte paired mutagenesis chromhmm

• Blood-based epigenetic instability linked to human aging and disease.

  PMID 41690920 · PMC13018287 · Nature communications · 2026 · 7 claims · 8 setups

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  31,744 unmethylated (and 6143 methylated) CpG loci in blood show highly consistent, stable methylation in young healthy individuals and are defined as Epigenetically Stable Loci (ESLs)

  blood normal paired aml illumina whole-genome methylation

• The 1000 Chinese Pangenome empowers medical and population genetics.

  PMID 41922767 · PMC13233627 · Nature · 2026 · 8 claims · 8 setups

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  1,116 diploid genome assemblies (55 de novo, 1,061 pangenome-informed) were generated as part of the 1KCP project

  genomic diploid benchmark illumina pacbio hi-c

• Single-cell spatiotemporal dissection of the human maternal-fetal interface.

  PMID 41951740 · PMC13149032 · Nature · 2026 · 8 claims · 8 setups

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  Generated a comprehensive single-cell multiomic and spatial atlas of the human maternal-fetal interface from early gestation to term

  decidua maternal-fetal pseudobulk trophoblast paired genotype snatac-seq