Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Cohesin regulates alternative splicing.

  PMID 36857449 · PMC9977177 · Science advances · 2023 · 7 claims · 8 setups

  Full-text index only

  Cohesin regulates alternative splicing independently of its effects on transcription.

  hct116rmac hct116 recombinant hek293 bulk rt-pcr proximity

• Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs.

  PMID 32515737 · PMC7282809 · eLife · 2020 · 8 claims · 3 setups

  Has reproduction · 90

  Both cohesin conversion and Scc2-dependent de novo loading mechanisms generate cohesion in S. cerevisiae, each requiring a distinct set of replisome-associated proteins.

  cerevisiae cohesin calibrated flow

• Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex.

  PMID 31201089 · PMC6675936 · Molecular cell · 2019 · 8 claims · 8 setups

  Has reproduction · 64

  Smc1 and Smc3 ATPase heads adopt two distinct interaction states in vivo: an ATP-dependent engaged (E) state and a signature-motif juxtaposed (J) state, and these are mutually exclusive.

  cerevisiae cysteine double single

• The application of basic science to translational cancer research.

  PMID 12620114 · PMC151297 · Genome biology · 2003 · 8 claims · 8 setups

  Full-text index only

  Sister-chromatid separation at anaphase is triggered by degradation of securin, releasing the protease separase to cleave the cohesin ring holding chromatids together

  yeast lamin tumor breast protease-cleavage rad53 brdu