Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
-
Has reproduction · 64
Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex.
PMID 31201089 · PMC6675936 · Molecular cell · 2019 · 8 claims · 8 setups
Smc1 and Smc3 ATPase heads adopt two distinct interaction states in vivo: an ATP-dependent engaged (E) state and a signature-motif juxtaposed (J) state, and these are mutually exclusive.
-
Full-text index only
The cohesin complex: sequence homologies, interaction networks and shared motifs.
PMID 11276426 · PMC30708 · Genome biology · 2001 · 8 claims · 8 setups
Mouse Mmip1 and Smc3 (SMCD) share 99% sequence identity and are products of the same gene
-
Full-text index only
Cohesin regulates alternative splicing.
PMID 36857449 · PMC9977177 · Science advances · 2023 · 7 claims · 8 setups
Cohesin regulates alternative splicing independently of its effects on transcription.
-
Has reproduction · 90
Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs.
PMID 32515737 · PMC7282809 · eLife · 2020 · 8 claims · 3 setups
Both cohesin conversion and Scc2-dependent de novo loading mechanisms generate cohesion in S. cerevisiae, each requiring a distinct set of replisome-associated proteins.
-
Has reproduction · 80
The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.
PMID 29754816 · PMC6371919 · Cell · 2018 · 8 claims · 7 setups
Co-entrapment of sister DNAs inside cohesin rings (CDs) correlates perfectly with sister chromatid cohesion across multiple cell-cycle stages and mutants