Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Collagen VI glycine mutations: perturbed assembly and a spectrum of clinical severity.

  PMID 18825676 · PMC2743946 · Annals of neurology · 2008 · 8 claims · 6 setups

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  All eight new patients had heterozygous glycine substitution mutations toward the N-terminal end of the collagen VI triple helix

  dermal skeletal fibroblast confluent rt-pcr immunohistochemistry biosynthetic

• Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair.

  PMID 41844625 · PMC13250124 · NPJ Regenerative medicine · 2026 · 8 claims · 8 setups

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  Localized Wnt3a signaling asymmetrically distributes H3K14ac between daughter cells during hSSC asymmetric cell division (ACD), with the Wnt-proximal cell retaining high H3K14ac and higher transcriptional activity (RNApolS2P)

  skeletal hssc hsscs wiotm immunofluorescence tunel doxycycline-inducible

• Proteomics reveals multiple routes to the osteogenic phenotype in mesenchymal stem cells.

  PMID 17949499 · PMC2148065 · BMC genomics · 2007 · 8 claims · 8 setups

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  ECM-stimulated hMSC and OS-media-stimulated hMSC represent two distinct intermediate/transitional phenotypes en route to becoming osteoblasts

  naive hmsc osteoblasts proteomic lc-ms gene computational

• Comparative proteomic analysis of cell lines and scrapings of the human intestinal epithelium.

  PMID 17407598 · PMC1852558 · BMC genomics · 2007 · 8 claims · 7 setups

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  Global protein expression profiles of cultured intestinal epithelial cell lines differ from those of intestinal epithelial scrapings in vivo

  caco-2 ht-29 hep muscle 2-d 2-de principal

• RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis.

  PMID 41746718 · PMC13078889 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  LARP6 is upregulated in activated hepatic stellate cells (A1/A2 subclusters) in human MASH and MetALD livers

  hepatic liver recombinant activated eclip ribosome single-nucleus

• Expanding the clinical spectrum of COL2A1 related disorders by a mass like phenotype.

  PMID 35296718 · PMC8927422 · Scientific reports · 2022 · 8 claims · 8 setups

  Has reproduction · 84

  Four FBN1-negative patients from three families with a MASS-like phenotype carry likely pathogenic or uncertain-significance missense variants in the propeptide-coding regions of COL2A1

  blood-derived four patients col2a1 targeted clinical transthoracic

• In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells.

  PMID 32665556 · PMC7360550 · Nature communications · 2020 · 8 claims · 8 setups

  Has reproduction · 50

  Cancer cells in vivo display higher coherent orientation of MT dynamics along their major axis compared to 2D in vitro cultures

  ht1080-eb3-mapple es2-eb3-mapple ht1080 cancer intravital live-cell confocal

• Transcriptome profiling of osteoclast subsets associated with arthritis: A pathogenic role of CCR2(hi) osteoclast progenitors.

  PMID 36591261 · PMC9797520 · Frontiers in immunology · 2022 · 8 claims · 6 setups

  Has reproduction · 50

  CCR2hi and CCR2lo periarticular bone marrow OCP subsets show a disparate transcriptome (863 differentially expressed genes)

  sorted rna-seq periarticular bulk gene flow

• Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs.

  PMID 34811438 · PMC8608887 · Scientific reports · 2021 · 8 claims · 8 setups

  Has reproduction · 50

  Human osteoclasts differentiate on cartilage, expressing osteoclast markers, and visibly damage the cartilage surface without forming resorption pits or F-actin rings as seen on dentine.

  cd14+ osteoclasts conditioned osteoclast gag direct

• Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion.

  PMID 14580259 · PMC314413 · Breast cancer research : BCR · 2003 · 7 claims · 4 setups

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  ER-negative cell clusters are far more likely than ER-positive clusters to overlie disrupted myoepithelial cell layers, both at the case level and the individual-disruption level

  paraffin selected microdissected double immunohistochemistry loss

• A need for a 'whole-istic functional genomics' approach in complex human diseases: arthritis.

  PMID 12718747 · PMC165036 · Arthritis research & therapy · 2003 · 8 claims · 6 setups

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  A systems ('whole-istic') functional genomics approach integrating multiple technologies and biological levels (cell, tissue, organ, organism) is necessary to understand complex diseases like arthritis.

  oa-affected cartilage type zebrafish gene differential genetic

• A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.

  PMID 16941570 · PMC1869047 · Proteomics · 2006 · 8 claims · 7 setups

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  96 proteins undergo post-translational modification (phosphorylation) in response to CRP stimulation of human platelets, including 11 proteins not previously identified in platelets

  washed 293t g6f-transfected hek phosphotyrosine 2-de western

• Proteomic and functional characterisation of platelet microparticle size classes.

  PMID 19806257 · PMC2861410 · Thrombosis and haemostasis · 2009 · 8 claims · 8 setups

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  PMP separated by gel filtration into 4 size classes differ in protein content, phospholipid/protein ratio, and functional effects on platelets and endothelial cells

  pooled pmp citrated huvec gel dynamic lipid

• Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.

  PMID 41501466 · PMC12820784 · Nature · 2026 · 8 claims · 8 setups

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  Inflammation-associated fibroblasts (IAFs), induced by proinflammatory FCN1+IL1B+ macrophages, produce profibrotic IL-11 and drive fibrosis in IBD

  intestinal colon pdgfra+ colonic scrna-seq xenium masson's

• IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration.

  PMID 41559031 · PMC12819398 · Cell discovery · 2026 · 8 claims · 8 setups

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  Aging reduces hASC self-renewal, lineage plasticity (adipogenic/osteogenic differentiation), and in vivo tissue repair efficacy

  i-hascs full-thickness nude hascs edu scratch adipogenic

• Modeling embryonic heart vascular plexus development and sympathetic innervation on a human heart organoid.

  PMID 41858891 · PMC12996818 · iScience · 2026 · 8 claims · 7 setups

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  Modulating VEGF and PDGFβ signaling during EMO generation induces a functional, self-generated coronary-like vascular plexus (V-EMOs/P-EMOs)

  hipsc-derived d10cc v-emos emos immunofluorescence single-cell fluorescent

• CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2(+) endothelial cells.

  PMID 41887221 · PMC13130657 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  CAR-M2 macrophages (anti-FAP CAR + IL-4-secreting, 4-1BB/CD3ζ costimulatory domains) specifically target and phagocytose FAP+ fibroblasts

  kidney car-m2 macrophages uuo scrna-seq histology live-cell

• Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

  PMID 41907400 · PMC13018967 · iScience · 2026 · 8 claims · 8 setups

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  Colorectal cancer fibroblast heterogeneity can be distilled into two overarching, transcriptomically distinct CAF populations marked by PDGFRA+ and ACTA2+ expression

  crc colonic gemm scrna-seq multiplex bulk

• The heterogeneity of dermal mesenchymal cells reproduced in skin equivalents regulates barrier function and elasticity.

  PMID 41922844 · PMC13172354 · EMBO reports · 2026 · 7 claims · 8 setups

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  Tricellular communication among epidermal keratinocytes, dermal fibroblasts, and vascular endothelial cells (EDV model) is required for normal epidermal organization, endothelial tube formation, and collagen deposition compared to models lacking one or more cell types.

  hse edv h&e sirius immunohistochemistry

• Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.

  PMID 41931622 · PMC13048245 · Science advances · 2026 · 7 claims · 8 setups

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  Brain-specific (neural crest-derived, NC-SMC) but not peripheral (LPM-SMC/PM-SMC) iPSC-derived VSMCs are selectively vulnerable to CADASIL NOTCH3 variants

  ipsc-derived ivsmcs immunofluorescence wound collagen