Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single nuclei and spatial profiling of sacrococcygeal teratomas reveals cellular composition and X inactivation heterogeneity.

  PMID 41565739 · PMC12949016 · NPJ precision oncology · 2026 · 7 claims · 4 setups

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  snRNA-seq and spatial transcriptomics of eight SCTs identify five broad cell lineages (neuroectoderm, epithelia, stroma, endothelia, immune) resolved into 26 transcriptionally distinct subtypes

  postnatal prenatal aggregated single-nucleus single-cell spatial

• Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.

  PMID 41576947 · PMC12985369 · Cell genomics · 2026 · 7 claims · 7 setups

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  snRNA-seq census of 227,680 nuclei across 48 cell types reveals altered cellular states and compositional rewiring of the distal lung in ILD

  frozen lung flash-frozen spatial single-nucleus scrna-seq 10x

• Sequencing mRNA from cryo-sliced Drosophila embryos to determine genome-wide spatial patterns of gene expression.

  PMID 23951250 · PMC3741199 · PloS one · 2013 · 8 claims · 8 setups

  Has reproduction · 67

  Cryosectioning single blastoderm-stage D. melanogaster embryos along the A–P axis and sequencing mRNA from each slice yields reliable genome-wide spatial expression patterns.

  single methanol-fixed reads slice mrna-seq light-microscopy read

• Comprehensive cellular analysis with single-nucleus RNA-seq of archived PAXgene whole blood samples.

  PMID 41844163 · PMC13030975 · Cell reports methods · 2026 · 8 claims · 7 setups

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  Cell lysis (CL) nuclei isolation yields substantially more nuclei and less biased immune cell proportions than mechanical separation (MS)

  frozen paxgene cl-derived thawed single-nucleus confocal brightfield

• The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization.

  PMID 41978268 · PMC13076225 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  Single-nucleus Hi-C reveals CTCF-independent contact domains with stable boundaries defined by convergently oriented transcription units (TUs)

  chicken computational oocytes single-nucleus nome-seq rna-seq

• Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.

  PMID 41826324 · PMC13139607 · Nature communications · 2026 · 8 claims · 8 setups

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  T1D GWAS heritability is enriched in accessible chromatin of brain-resident cells, most notably microglia, across neurodevelopment into adulthood

  cortex single-nucleus gwas gtex stratified scavenge s-ldsc

• Spatial transcriptomics reveals expression gradients in developing wheat inflorescences at cellular resolution.

  PMID 41388990 · PMC12776951 · The Plant cell · 2026 · 8 claims · 6 setups

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  MERFISH was successfully optimized for wheat inflorescence tissue, enabling localization of a 200-gene panel to cellular resolution across 4 developmental stages

  microdissected cryosectioned wheat merfish-imaged bulk merfish single-nucleus

• Regulatory-like FOXP3+Helios+CD4+ T conventional cells correlate with T-cell activation after Orca-T immunotherapy.

  PMID 41758930 · PMC13197979 · Blood · 2026 · 8 claims · 6 setups

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  Orca-T immunotherapy leads to increased phenotypic T-cell activation compared with unmanipulated PBSC grafts, persisting for months after treatment.

  peripheral sorted fresh cryopreserved flow single-cell tcr

• RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis.

  PMID 41746718 · PMC13078889 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  LARP6 is upregulated in activated hepatic stellate cells (A1/A2 subclusters) in human MASH and MetALD livers

  hepatic liver recombinant activated eclip ribosome single-nucleus

• Highly efficient chromatin conformation capture with post-enrichment in single cells by HiChew.

  PMID 42036683 · PMC13112749 · Genome biology · 2026 · 8 claims · 8 setups

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  HiChew achieves approximately 50% valid pair ratios compared to about 8% for unenriched methods like Dip-C

  hek293t chromosome gm12878 hichew dip-c sequencing

• Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.

  PMID 41673768 · PMC12998334 · Journal of experimental & clinical cancer research : CR · 2026 · 6 claims · 8 setups

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  Organoids derived from malignant effusions of PDAC patients reproducibly generate peritoneal metastases after orthotopic implantation into the pancreas of immunodeficient mice

  pdac organoids frozen pdox orthotopic single-nucleus single-cell