Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.
PMID 19714203 · PMC2722018 · PLoS computational biology · 2009 · 8 claims · 8 setups
Cancer mutations in ABL and EGFR activate kinases via a common multi-stage mechanism involving hydrophobic spine assembly, formation of a Src-like intermediate structure, and cooperative breakage/formation of characteristic salt bridges
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Finding the needle in the haystack: why high-throughput screening is good for your health.
PMID 12100740 · PMC138735 · Breast cancer research : BCR · 2002 · 8 claims · 8 setups
HTS is essential for finding lead compounds, especially for novel targets whose active-site structure is unknown
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Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations.
PMID 19744331 · PMC2749040 · BMC structural biology · 2009 · 8 claims · 1 setups
The simulation-derived JH1/JH2 interface provides a platform that explains the mutational effect of all tested mutants, including presumably benign controls, at the atomic level
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Lipids join the post-genomic era.
PMID 17076911 · PMC1794566 · Genome biology · 2006 · 8 claims · 8 setups
Infrared-laser MALDI-MS can image biological tissue while avoiding the matrix-preparation artifacts of UV-laser MALDI