Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians.

  PMID 42030936 · PMC13198318 · Cell reports. Medicine · 2026 · 8 claims · 6 setups

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  LLIs exhibit a transcriptional age younger than expected for their chronological age, as measured by clocks trained on younger controls (YCs).

  peripheral european same age-related bulk gene machine

• Smoking promotes colorectal cancer via the CKAP2L/AREG axis.

  PMID 41823522 · PMC13038336 · International journal of oncology · 2026 · 8 claims · 8 setups

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  Smoking is positively associated with CRC risk, confirmed by both cross-sectional (NHANES) and Mendelian randomization analyses

  participants european crc hct116 cross-sectional two-sample single-cell

• The Aging Microenvironment Is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer.

  PMID 41202211 · PMC12768431 · Cancer research · 2026 · 8 claims · 8 setups

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  Organismal aging accelerates PDAC progression and metastatic burden in an age-relevant syngeneic orthotopic mouse model

  kpc4662 orthotopic pdac pancreatic orthotopic heterochronic ultrasound

• Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR.

  PMID 41771837 · PMC12953643 · Signal transduction and targeted therapy · 2026 · 8 claims · 8 setups

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  KLF15 transcriptional activity shows the most significant change among TFs in pathological cardiomyocytes during progressive hypertrophic remodeling, reflecting less effective repression of disease-associated genes.

  ventricular heart cardiomyocytes cardiomyocyte single-cell rt-qpcr bulk

• CD74 deficiency protects against doxorubicin cardiotoxicity through RRM2-mediated regulation of ferroptosis.

  PMID 42180553 · PMC13198236 · Acta pharmaceutica Sinica. B · 2026 · 8 claims · 8 setups

  Has reproduction · 29

  CD74 levels are elevated in plasma of DOX-exposed breast cancer patients and in DOX-challenged mouse hearts and cardiomyocytes

  plasma cd74− cardiomyocytes hearts elisa echocardiography cardiomyocyte