Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 9

System / cell line: histone ✕ Assay: cut&tag ✕ Clear

Bromodomain protein IBD1 bridges histone acetylation and H2A.Z deposition to fine-tune transcription.

PMID 41728948 · PMC12926916 · Nucleic acids research · 2026 · 8 claims · 8 setups

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IBD1's bromodomain recognizes H3K9/K14 di-acetylation to recruit the SWR complex subunit ARP6, ensuring precise H2A.Z incorporation into chromatin

tetrahymena recombinant native cut&tag sequencing
Mechanisms of gene regulation by SRCAP and H2A.Z.

PMID 41792122 · PMC13087030 · Nature communications · 2026 · 8 claims · 8 setups

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Acute SRCAP degradation causes rapid, genome-wide replacement of H2A.Z by canonical H2A, with turnover fastest at active promoters/enhancers and slower at bivalent loci

syat cut&run live h2a.z
Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features.

PMID 41667493 · PMC13002996 · Nature communications · 2026 · 8 claims · 8 setups

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6-base-CUT&Tag (6B-C&T) simultaneously maps G, A, T, C, 5mC, and 5hmC at antibody-targeted chromatin features on the same DNA fragment

e14tg2a synthetic mescs mesc 6-base-cut&tag standard exonuclease
Sequential RNA polymerase II activation drives human hematopoiesis.

PMID 41520338 · PMC13067999 · Cell reports · 2026 · 7 claims · 7 setups

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sciCUT&Tag2in1 enables simultaneous single-cell combinatorial-indexing profiling of Pol II occupancy (Ser5/Ser2-phospho CTD) together with histone modifications (H3K4me1-2-3 or H3K27me3) in up to 50,000 cells per experiment

g-csf-mobilized cd34+ 10-donor lineage-depleted scicut&tag2in1 individual souporcell
Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair.

PMID 41844625 · PMC13250124 · NPJ Regenerative medicine · 2026 · 8 claims · 8 setups

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Localized Wnt3a signaling asymmetrically distributes H3K14ac between daughter cells during hSSC asymmetric cell division (ACD), with the Wnt-proximal cell retaining high H3K14ac and higher transcriptional activity (RNApolS2P)

skeletal hssc hsscs wiotm immunofluorescence tunel doxycycline-inducible
Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses.

PMID 41813846 · PMC13083880 · The EMBO journal · 2026 · 8 claims · 8 setups

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CAPN3 promotes rapid dissociation of PRC1 complexes from chromatin in response to stress

hepatocytes liver doxycycline-inducible capn3 chip-seq cut&tag western
Evolutionary innovation within conserved gene regulatory networks underlying biomineralized skeletons in Bilateria.

PMID 41556888 · PMC12862220 · Molecular biology and evolution · 2026 · 8 claims · 6 setups

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A biphasic regulatory program orchestrates larval and adult shell formation in Crassostrea nippona, involving coordinated activity of ancient transcription factors and dynamic chromatin remodeling

crassostrea iso-seq rna-seq atac-seq
Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

PMID 41850280 · PMC13103949 · Cell reports · 2026 · 8 claims · 8 setups

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Chemotherapy-resistant KT-47R tumors show blastemal predominance and reduced stromal content compared to pre-treatment KT-47PT

kt-47 kt-47pt histology whole-exome cut&tag
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements.

PMID 41632506 · PMC12867480 · eLife · 2026 · 8 claims · 8 setups

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CHD4 acts via a second mechanism beyond nucleosome sliding: actively restricting the residence time of transcription factors on chromatin

chd4-maid sall1 western flow calibrated

Experiments

Bromodomain protein IBD1 bridges histone acetylation and H2A.Z deposition to fine-tune transcription.

Mechanisms of gene regulation by SRCAP and H2A.Z.

Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features.

Sequential RNA polymerase II activation drives human hematopoiesis.

Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair.

Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses.

Evolutionary innovation within conserved gene regulatory networks underlying biomineralized skeletons in Bilateria.

Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements.