Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 4

System / cell line: stage ✕ Assay: cut&tag ✕ Clear

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development.

PMID 41355514 · PMC12848575 · Development (Cambridge, England) · 2026 · 8 claims · 8 setups

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NR5A2 chromatin binding is dynamic, changing genome-wide from the 2-cell to the morula stage, with peak numbers and target regions (e.g. SINE B1/Alu) shifting over developmental time

2-cell embryonic 8-cell zygotes cut&tag chip-seq h3k27ac
Mechanisms of gene regulation by SRCAP and H2A.Z.

PMID 41792122 · PMC13087030 · Nature communications · 2026 · 8 claims · 8 setups

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Acute SRCAP degradation causes rapid, genome-wide replacement of H2A.Z by canonical H2A, with turnover fastest at active promoters/enhancers and slower at bivalent loci

syat cut&run live h2a.z
Evolutionary innovation within conserved gene regulatory networks underlying biomineralized skeletons in Bilateria.

PMID 41556888 · PMC12862220 · Molecular biology and evolution · 2026 · 8 claims · 6 setups

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A biphasic regulatory program orchestrates larval and adult shell formation in Crassostrea nippona, involving coordinated activity of ancient transcription factors and dynamic chromatin remodeling

crassostrea iso-seq rna-seq atac-seq
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements.

PMID 41632506 · PMC12867480 · eLife · 2026 · 8 claims · 8 setups

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CHD4 acts via a second mechanism beyond nucleosome sliding: actively restricting the residence time of transcription factors on chromatin

chd4-maid sall1 western flow calibrated

Experiments

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development.

Mechanisms of gene regulation by SRCAP and H2A.Z.

Evolutionary innovation within conserved gene regulatory networks underlying biomineralized skeletons in Bilateria.

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements.