Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Tumor-specific but immunosuppressive CD39(+)CD8(+) T cells exhibit double-faceted roles in clear cell renal cell carcinoma.

  PMID 40961944 · PMC12629791 · Cell reports. Medicine · 2025 · 8 claims · 8 setups

  Has reproduction · 88

  CD39+CD8+ TILs constitute a terminally exhausted, tumor-antigen-specific subset of CD8+ T cells

  memory sorted caix-specific cd39+pd-1bright scrna-seq bulk mhc

• PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy.

  PMID 33188038 · PMC7668369 · Journal for immunotherapy of cancer · 2020 · 7 claims · 6 setups

  Has reproduction · 75

  The frequency of circulating PD-1+TIGIT+ (DPOS) CD8+ T cells after 1 month of anti-PD-1 therapy is associated with clinical response and overall survival

  pbmcs sorted expanded cancer multiparameter receptor targeted

• Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy.

  PMID 41680482 · PMC12920136 · Nature medicine · 2026 · 7 claims · 7 setups

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  Anti-PD-1 therapy triggers a rapid (within 24 hours) systemic cascade of increased IFN/antiviral, monocyte, and CD8+ T cell effector transcriptomic modules alongside decreased plasma TGFβ.

  pbmcs plasma pbmc publicly bulk plasma integrated

• Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7.

  PMID 41920738 · PMC13222646 · Cell reports · 2026 · 8 claims · 8 setups

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  NT-I7 preferentially expands PD-1+TCF1+Tim-3- stem-like virus-specific CD8 T cells rather than effector/TD subsets during chronic LCMV infection

  chronic chronically lcmv-specific spleen flow ki67 intracellular

• Genomic and Immune Landscape of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Progressing on Anti-PD-1 Treatment.

  PMID 41666253 · PMC13044521 · Cancer immunology research · 2026 · 6 claims · 8 setups

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  Tumor biopsies from anti-PD-1-resistant SCCHN show significantly more EGFR and MYCL amplifications and increased MYC pathway alterations compared with anti-PD-1-naive tumors

  ffpe blood tumor whole-exome bulk multiplex

• TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size.

  PMID 41862649 · PMC13043299 · Nature immunology · 2026 · 8 claims · 7 setups

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  Combo treatment (anti-IL-10 + anti-PD-1) induces IFN/antiviral gene signatures pre-ATI that are inversely correlated with CA-vDNA, CA-vRNA and 2-LTR circles post-ATI

  lnmcs plasma cd4+ rhesus bulk high-dimensional plasma

• Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy.

  PMID 33723257 · PMC7961017 · Nature communications · 2021 · 7 claims · 7 setups

  Has reproduction · 70

  Proportions of activated and proliferating CD8+ T cells (cluster C16/activated EM) are significantly higher in responders before and during therapy

  pbmc cd3+cd8+ pbmc-derived metastatic high-dimensional single-cell polychromatic

• Vaccine-induced ICOS(+)CD38(+) circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.

  PMID 34095875 · PMC8149371 · Cell reports. Medicine · 2021 · 8 claims · 8 setups

  Has reproduction · 88

  Vaccine-induced ICOS+CD38+ cTfh from elderly adults show increased TNF-NF-κB pathway transcriptional signaling compared to young adults at day 7 post-vaccination

  pbmc sorted rna-seq icos+cd38+ flow bulk gene

• Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers.

  PMID 41484081 · PMC12858953 · Nature communications · 2026 · 8 claims · 8 setups

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  Combined low-dose CTX + anti-CSF-1R (SNDX-ms6352) is highly effective against aggressive metastatic Trp53-null TNBC models with high macrophage infiltration, producing complete tumor regression in claudin-low models.

  trp53-null complete t12 cell-deficient imaging survival tumor

• Transient tumor exposure induces persistent functional defects in memory CD8(+) T cells.

  PMID 42023146 · PMC13098610 · iScience · 2026 · 8 claims · 8 setups

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  Memory CD8+ T cells generated after transient tumor rejection (Tum-CD8+) display a distinct, partially exhausted phenotype compared to virus-induced memory cells (Vir-CD8+)

  cd45.1 single-cell memory ctv flow single-cell cytokine

• TOPK Suppresses the CD8(+) T Cell Antitumor Immunity via Modulation of IRF5 Expression.

  PMID 41868885 · PMC13003159 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups

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  A TOPK+ subset of tumor-infiltrating CD8+ T cells exists in melanoma at higher frequency than in normal lymph nodes and shows suppressed cytotoxic/cytokine programs.

  tumor-infiltrating melanoma b16-f10 unspecified scrna-seq flow multiplex

• Vitamin C Conditioning Generates Tumor-Targeting CAR T Cells with Superior Cytotoxicity and Fitness in a Posttransplant Lymphoproliferative Disorder Tumor Model.

  PMID 41416402 · PMC13136873 · Molecular cancer therapeutics · 2026 · 8 claims · 8 setups

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  VitC conditioning enhances transduction efficiency and proliferative capacity, yielding a higher yield of CD4+ and CD8+ CAR19-Ts

  cd3+ je6-1 car19-ts coculture flow nf-κb cytotoxicity

• Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.

  PMID 41533733 · PMC12829949 · PLoS pathogens · 2026 · 8 claims · 8 setups

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  Aged Nr4a3-Tocky mice develop more severe pneumonia and delayed body weight recovery after SARS-CoV-2 infection than adult mice

  nr4a3-tocky bronchoalveolar lung left viral histopathology immunohistochemistry

• Metabolic adaptations rewire CD4(+) T cells in a subset-specific manner in human critical illness with and without sepsis.

  PMID 41540263 · PMC12864044 · Nature immunology · 2026 · 8 claims · 7 setups

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  CD4+ T cells in critical illness show subset-specific metabolic plasticity, with regulatory T (Treg) cells preferentially acquiring glycolytic capacity

  pbmc-derived peripheral cd4+ puromycin-incorporation complete expression

• CLK1 Promotes Myeloid-Derived Suppressor Cell Trafficking and Reprograms the Tumor Microenvironment by Activating Hippo/YAP Signaling in Colorectal Cancer.

  PMID 41686262 · PMC13136879 · Cancer immunology research · 2026 · 8 claims · 8 setups

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  CLK1 is markedly upregulated in immune-cold colorectal tumors and correlates with increased MDSC infiltration and CD8+ T-cell exclusion

  colorectal tcga-coad ct26 tumor scrna-seq bulk multiplex

• The transcription factor EHF promotes the maturation and immunosuppression of conventional dendritic cells.

  PMID 41730908 · PMC13039115 · Nature communications · 2026 · 8 claims · 8 setups

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  EHF orchestrates an immunosuppressive maturation program in cDC1s and cDC2s downstream of TLR7/8/9 sensing of self-nucleic acids

  ehf facs-sorted dss-induced lethal cd4+

• CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.

  PMID 41746743 · PMC13078883 · The Journal of clinical investigation · 2026 · 8 claims · 8 setups

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  CD38 is markedly more highly expressed on cord blood (CB) naive CD4+ T cells than adult blood (AB) naive CD4+ T cells, with an age-dependent gradient from fetal to pediatric life.

  pbmcs sorted scrna-seq naive flow bulk compass