Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 17

System / cell line: scrna-seq ✕ Assay: density ✕ Clear

Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.

PMID 41704758 · PMC12907124 · iScience · 2026 · 8 claims · 8 setups

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Aurkb is upregulated in a subset of fetal/neonatal microglia and in microglia following CPZ-induced demyelination and in MS patient microglia

microglia brain neonatal corpus scrna-seq western immunofluorescence
Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome.

PMID 40889886 · PMC13217081 · Gut · 2026 · 8 claims · 7 setups

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High density of CD20+ B cells in the peritumoural area is associated with improved disease-free survival in iCCA

resected cd45+ scrna-seq peripheral immunohistochemistry kaplan-meier scrna-seq
Single-cell landscape of piglet lung response with Actinobacillus pleuropneumoniae.

PMID 41843736 · PMC13014559 · Virulence · 2026 · 8 claims · 8 setups

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scRNA-seq of piglet lungs identified 18 cell subpopulations with distinct phenotypes in infected vs control lungs

piglet monocytes bronchoalveolar single-cell hematoxylin-and-eosin immunohistochemistry
CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2(+) endothelial cells.

PMID 41887221 · PMC13130657 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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CAR-M2 macrophages (anti-FAP CAR + IL-4-secreting, 4-1BB/CD3ζ costimulatory domains) specifically target and phagocytose FAP+ fibroblasts

kidney car-m2 macrophages uuo scrna-seq histology live-cell
Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging.

PMID 42010880 · PMC13096584 · Aging cell · 2026 · 8 claims · 8 setups

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T cells are the immune cell population with the most pronounced transcriptomic alterations during liver aging

liver nash cirrhotic hcc scrna-seq snrna-seq stereo-seq
Reconstructing single-cell resolution from spatial transcriptomics with CellRefiner.

PMID 41760664 · PMC13066420 · Nature communications · 2026 · 8 claims · 8 setups

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CellRefiner is a physical/particle-based model (subcellular element method) that integrates scRNA-seq and spatial transcriptomics data to reconstruct single-cell resolution spatial data

hypothalamic embryo hippocampus visual merfish seqfish slide-seqv2
POSTN(+) fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling.

PMID 41645751 · PMC12891935 · Oncology reports · 2026 · 8 claims · 8 setups

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Integration of two HNSCC scRNA-seq datasets reveals two distinct fibroblast subtypes: POSTN- and POSTN+ fibroblasts

hnscc tcga-hnscc oscc oscc-derived single-cell bulk immunohistochemistry
Leveraging RNA-seq deconvolution to improve complex in vitro model characterization.

PMID 40701251 · PMC12391696 · The Journal of biological chemistry · 2025 · 8 claims · 6 setups

Has reproduction · 67

RNA-seq deconvolution can predict cell type proportions from bulk RNA-seq using scRNA-seq references, offering a useful characterization tool for CIVMs where single-cell methods are impractical

intestine rodent duodenal neonatal bulk scrna-seq marker
Rete ridges form via evolutionarily distinct mechanisms in mammalian skin.

PMID 41639458 · PMC12959975 · Nature · 2026 · 8 claims · 8 setups

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Rete ridges form through a mechanism independent from hair follicles and sweat glands, via interconnected epidermal invaginations

trunk pig multispecies gw12 histology comparative immunostaining
M(5)C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance.

PMID 41673397 · PMC12921336 · Cell death & disease · 2026 · 8 claims · 8 setups

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RNA m5C levels are globally and consistently elevated in cervical tumors compared to normal cervical tissue

cervical hela nsun2 bisulfite bulk spatial
Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation.

PMID 41851525 · PMC13132723 · Nature immunology · 2026 · 8 claims · 8 setups

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Microglia repopulate rapidly and exclusively cell-autonomously from surviving microglia after CSF-1R inhibitor (BLZ945) depletion.

brain cerebral cd11b+cd45int-hi leptomeninges flow confocal single-cell
Reinvigorating COTL1(high) NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours.

PMID 41912896 · PMC13179135 · Nature cell biology · 2026 · 8 claims · 8 setups

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A COTL1-high NK cell subset mediates immune checkpoint blockade responsiveness in tsMHC-I impaired tumours

hcc sorted orthotopic multiplex bulk single-cell
LIMCH1-enriched extracellular vesicles promote vascular permeability in early-onset preeclampsia.

PMID 41604492 · PMC12851021 · Science advances · 2026 · 8 claims · 8 setups

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LIMCH1 is identified as an Eo-PE-associated EV protein via serum sEV proteomics combined with GEO placental transcriptome datasets

serum placenta jar huvecs lc-ms exoview nanoflow
Development and validation of a gemcitabine sensitivity-related long noncoding RNA signature for predicting the prognosis and subtypes of bladder cancer.

PMID 41809777 · PMC12968932 · Translational andrology and urology · 2026 · 8 claims · 8 setups

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A 37-GSRlncRNA prognostic signature stratifies BLCA patients into low- and high-risk groups with significant differences in survival, pathway enrichment, immune infiltration, and mutational profiles

tcga-blca blca paired wgcna differential machine
Spatiotemporal dynamics of ecto-5'-nucleotidase (CD73) in mouse retina under physiological conditions.

PMID 41560519 · PMC12912271 · Development (Cambridge, England) · 2026 · 8 claims · 6 setups

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CD73 expression in the neural retina is restricted to the rod-photoreceptor lineage and becomes robustly detectable from postnatal day (P) 3 onward, persisting into adulthood.

cd73-bac-egfp cd73-creert2 scrna-seq cd73-knockout immunofluorescence genetic whole-mount
FRMD8 inhibits tumor metastasis in BRCA1-associated TNBC by negatively regulating tmTNF-α.

PMID 40619383 · PMC12229025 · Cellular & molecular biology letters · 2025 · 8 claims · 8 setups

Has reproduction · 73

Low FRMD8 expression in BRCA1-mutant breast cancer cells significantly enhances metastatic potential to various organs

tnbc geo breast frmd8 bulk meta-analysis single-cell
Identification and validation of prognostic genes associated with M2 macrophage and heme metabolism in lung adenocarcinoma through bulk and single-cell RNA sequencing analysis.

PMID 41787185 · PMC13076703 · Discover oncology · 2026 · 8 claims · 8 setups

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EPB41, ACP5, PPOX, RBM38, and TRIM58 were identified as prognostic genes for LUAD

tcga-luad gse131907 clinical cibersort gsea spearman

Experiments

Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination.

Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome.

Single-cell landscape of piglet lung response with Actinobacillus pleuropneumoniae.

CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2(+) endothelial cells.

Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging.

Reconstructing single-cell resolution from spatial transcriptomics with CellRefiner.

POSTN(+) fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling.

Leveraging RNA-seq deconvolution to improve complex in vitro model characterization.

Rete ridges form via evolutionarily distinct mechanisms in mammalian skin.

M(5)C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance.

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation.

Reinvigorating COTL1(high) NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours.

LIMCH1-enriched extracellular vesicles promote vascular permeability in early-onset preeclampsia.

Development and validation of a gemcitabine sensitivity-related long noncoding RNA signature for predicting the prognosis and subtypes of bladder cancer.

Spatiotemporal dynamics of ecto-5'-nucleotidase (CD73) in mouse retina under physiological conditions.

FRMD8 inhibits tumor metastasis in BRCA1-associated TNBC by negatively regulating tmTNF-α.

Identification and validation of prognostic genes associated with M2 macrophage and heme metabolism in lung adenocarcinoma through bulk and single-cell RNA sequencing analysis.