Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 42
The electrostatic profile of consecutive Cβ atoms applied to protein structure quality assessment.
PMID 25506420 · PMC4257144 · F1000Research · 2013 · 8 claims · 8 setups
The EPD between Cβ atoms of consecutive residues provides unique signatures of amino acid pair types and can discriminate native from decoy protein structures.
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Predicting deleterious nsSNPs: an analysis of sequence and structural attributes.
PMID 16630345 · PMC1489951 · BMC bioinformatics · 2006 · 8 claims · 7 setups
Sequence conservation (PSIC score difference) at the nsSNP position is the single most useful attribute for predicting deleterious vs neutral status.
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Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.
PMID 17318599 · PMC1915625 · Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2007 · 7 claims · 7 setups
The T309V mutation shifts the CYP2D6 heme spin equilibrium toward the six-coordinate low-spin (6cLS) state, decreasing the five-coordinate high-spin (5cHS) fraction relative to wild type.
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Evolutionary trace annotation of protein function in the structural proteome.
PMID 20036248 · PMC2831211 · Journal of molecular biology · 2010 · 8 claims · 7 setups
ET-ranked residue clusters can be used to build 3D templates that predict GO function in enzymes and non-enzymes alike, without prior knowledge of functional mechanism.