Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• TOFU-MAaPO: fast, scalable and reproducible analysis of large metagenome sequence data from the Sequence Read Archive.

  PMID 42277027 · PMC13260335 · Nature communications · 2026 · 8 claims · 5 setups

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  TOFU-MAaPO yields significantly more high-quality MAGs than metaFun, nf-core/mag, and ATLAS due to integration of multiple complementary binning tools with unified MAGScoT refinement

  gut same uniquely metagenome quality assembly-free

• Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma.

  PMID 41540108 · PMC13004696 · Nature medicine · 2026 · 7 claims · 7 setups

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  GPRC5D antigenic drift/mutational events occurred in 68.4% of relapsed cases following anti-GPRC5D TCE therapy (13/19 evaluable patients)

  cd138+ pbmcs cohort bulk single-cell targeted

• Integrating human plasma proteomes with genome-wide association data implicates novel proteins and drug targets for rheumatoid arthritis.

  PMID 41540382 · PMC12892679 · Clinical proteomics · 2026 · 8 claims · 8 setups

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  PWAS integrating RA GWAS with ARIC and INTERVAL plasma pQTL data identified 35 genetically regulated proteins (42 associations) significantly associated with RA risk.

  plasma shared gtex blood proteome-wide two-sample bayesian

• Discovery and Evaluation of Biomarkers for Triple-Negative Breast Cancer Subtypes Uncovers Patient Stratification and Targeted Therapeutic Strategies.

  PMID 41671401 · PMC13176827 · Cancer research · 2026 · 7 claims · 8 setups

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  A set of basal identity genes (SMA/ACTA2, TAGLN, TPM2) defined by scRNA-seq analysis enables subclassification of TNBC into a subgroup termed true basal TNBC (tB-TNBC)

  healthy ffpe tcga i-spy2 scrna-seq immunohistochemistry bulk

• SiCmiR Atlas: Single-Cell miRNA Landscape Reveals Hub-miRNA and Network Signatures in Human Cancers.

  PMID 41691474 · PMC13042402 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  SiCmiR, a two-layer neural network, predicts mature miRNA expression profiles from only 977 LINCS L1000 landmark genes

  tcga k562 pancreatic acth-secreting paired bulk scrna-seq-based

• Identification and validation of lymphangiogenesis-related genes for predicting acute myeloid leukemia prognosis: insights from bulk RNA sequencing and single-cell RNA sequencing analyses.

  PMID 41772327 · PMC12979290 · Clinical and experimental medicine · 2026 · 7 claims · 8 setups

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  A 6-LYMRG risk model (ANGPT1, HGF, MAPK8, PCNA, TBL1XR1, TLR4) is the optimal prognostic signature for AML

  gse142698 tcga-laml tcga-laml1 gse116256 differential univariate kaplan-meier

• Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics.

  PMID 41839886 · PMC12996611 · Nature communications · 2026 · 7 claims · 7 setups

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  mtscATAC-seq combined with POLG D274A hypermutator HEK293 lines reveals a substantially larger single-cell mtDNA mutational burden than previously appreciated by bulk sequencing

  hek293 pbmcs mitochondrial mtdna mutational

• Evaluating the Utilities of Foundation Models in Single-Cell Data Analysis.

  PMID 41869863 · PMC13170260 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  Among ten/eleven evaluated single-cell FMs, scGPT, Geneformer, and CellFM are the top models considering both performance and user accessibility

  scrna-seq unpaired single-cell scgpt batch multi-omic cell-type

• The macrophage entry mechanism of SARS-CoV-2 mediated by surface CD98/TMPRSS11E complex is associated with the cellular tropism toward proinflammatory M1 and pathogenesis.

  PMID 41877147 · PMC13137717 · Respiratory research · 2026 · 8 claims · 8 setups

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  CD98 (CD98hc/SLC3A2) is a novel receptor for the SARS-CoV-2 Spike protein

  thp-1-derived 293t structures thp-1 co-ip co-immunoprecipitation molecular

• Single-cell spatial transcriptomics reveals tumor microenvironment heterogeneity in primary and lymph node-metastatic small cell lung cancer.

  PMID 41916294 · PMC13130650 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  Three malignant subclusters (C5, C6, C9) are enriched in LNM tumors and display distinct metabolic and angiogenic programs alongside spatial immune exclusion

  pt-lnm spatial single-cell multi-organ single-cell multiplex h&e

• Long non-coding RNA profiling of hypertrophic cardiomyopathy in mice.

  PMID 41942516 · PMC13230700 · Scientific data · 2026 · 6 claims · 8 setups

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  This study presents a transcriptome-wide RNA-Seq dataset delineating differentially expressed lncRNAs in left ventricle of the TNNT2 ∆160 HCM mouse model (n=31 TG, n=33 nTG).

  left fastq rna-seq lncrna bulk fastqc read

• Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics.

  PMID 41946363 · PMC13130689 · Cell reports. Medicine · 2026 · 8 claims · 8 setups

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  Multi-lineage adult renal organoids (MAROs) can be established directly from adult human kidney tissue and expanded long-term while retaining proximal tubule and collecting duct lineages

  maros patient-derived pkd_orgs bulk single-cell immunofluorescence

• Hi-Compass: a depth-aware deep learning framework for predicting cell-type-specific 3D genome organization from single-cell to spatial resolution.

  PMID 41980945 · PMC13250166 · Nature communications · 2026 · 8 claims · 8 setups

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  Hi-Compass predicts cell-type-specific Hi-C contact maps using only ATAC-seq as cell-type-specific input, plus DNA sequence and a generalized CTCF binding profile

  gm12878 curated bulk training hi-c ctcf matched

• Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.

  PMID 42018614 · PMC13101850 · Science advances · 2026 · 8 claims · 8 setups

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  DNA methylation is a plausible causal driver of gene expression in the majority (73%) of tested eQTM pairs, more often than the reverse direction (28%)

  nasal genes snps types eqtm eqtl causal

• CSsingle: a unified tool for robust decomposition of bulk and spatial transcriptomic data across diverse single-cell references.

  PMID 42080261 · PMC13136905 · Nucleic acids research · 2026 · 8 claims · 8 setups

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  CSsingle explicitly corrects for cell-type-specific RNA content (cell size) differences using ERCC spike-ins or a novel computational estimator

  blood breast developing colorectal bulk scrna-seq spatial

• A comprehensive toolkit for analyzing cell-free DNA genomic sequencing data in liquid biopsy.

  PMID 42111187 · PMC13157187 · iScience · 2026 · 8 claims · 8 setups

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  cfDNAanalyzer integrates feature extraction, feature processing/selection, and machine learning model building into a single one-command-line toolkit for cfDNA genomic sequencing data

  balanced breast healthy multi-cancer cfdna machine computational

• mitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations.

  PMID 31799603 · PMC6954439 · Nucleic acids research · 2020 · 5 claims · 5 setups

  Has reproduction · 89

  mitoXplorer integrates transcriptome, proteome, and mutation data with a manually curated mitochondrial interactome of ~1200 genes grouped into 38 mitochondrial processes across four model species.

  rpe-1 trisomic rpe yeast bulk proteomics mitotracker

• Of rats and men.

  PMID 15003114 · PMC395761 · Genome biology · 2004 · 8 claims · 10 setups

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  The rat genome has been sequenced to draft level, with over 90% of the genome sampled using more than 36 million sequence reads (assembly version 3.1)

  rattus cftr fugu transgenic whole-genome comparative genome

• Report of the 9th HLPP Workshop October 2007, Seoul, Korea.

  PMID 18683817 · PMC4601560 · Proteomics · 2008 · 8 claims · 8 setups

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  An integrated separating-identifying platform identified 6788 proteins (≥2 peptides, 95% confidence) in Chinese human liver samples, including 3721 new to liver and 977 hypothetical proteins

  chinese liver hbv-related mammalian shotgun transcriptome yeast