Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 33

System / cell line: populations ✕ Assay: diversity ✕ Clear

Sex-biased evolutionary forces shape genomic patterns of human diversity.

PMID 18818765 · PMC2538571 · PLoS genetics · 2008 · 7 claims · 5 setups

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X-linked diversity is higher than the neutral expectation (0.75) relative to autosomal diversity in all six sampled human populations

humans population simulated computational resequencing coalescent-based coalescent
Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.

PMID 16847467 · PMC3099416 · The pharmacogenomics journal · 2007 · 8 claims · 6 setups

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NAT2 variants are homogeneously distributed across native populations of the American continent

chromosomes same inferred american pcr statistical haplotype
Melanesian mtDNA complexity.

PMID 17327912 · PMC1803017 · PloS one · 2007 · 8 claims · 5 setups

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Among-group mtDNA variation in Northern Island Melanesia is structured by island, island size, and language affiliation.

populations near mtdna mtdna analysis coalescence
Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.

PMID 18304320 · PMC2292740 · BMC genetics · 2008 · 8 claims · 8 setups

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NAT2 coding region sequence variation in the Mandenka and other sub-Saharan African populations is consistent with selective neutrality and constant population size.

mandenka worldwide hapmap nat2 full snp analysis
Inferring human colonization history using a copying model.

PMID 18497854 · PMC2367454 · PLoS genetics · 2008 · 8 claims · 6 setups

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A copying-model approach using SNP haplotype sharing can infer both the order of population founding and the donor populations contributing ancestry to each new population.

simulated populations coalescent snp ascertainment
The detection of regions of our genome under selection has increasingly relied on the use of genome scans.

PMID 16197732 · PMC3525123 · Human genomics · 2005 · 8 claims · 3 setups

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Markers linked to a locus under local adaptation show larger variance in allele frequencies across populations (higher FST) than neutral markers

populations common genome snp comparative
ddRAD-seq reveals the genetic structure and detects signals of selection in Italian brown trout.

PMID 35100964 · PMC8805291 · Genetics, selection, evolution : GSE · 2022 · 7 claims · 8 setups

Has reproduction · 87

Italian brown trout populations are genetically differentiated but show strong admixture introduced by stocking, especially with the Atlantic lineage.

salmo brown subset five ddrad-seq read population
Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region.

PMID 16684361 · PMC1488846 · BMC genomics · 2006 · 8 claims · 5 setups

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The coding region of MRP1 shows evidence of negative selection or recent population expansion based on nucleotide diversity statistics

healthy mrp1 population novo population functional
Increased constraints on MC4R during primate and human evolution.

PMID 19011902 · PMC9947067 · Human genetics · 2009 · 6 claims · 7 setups

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There is a significant paucity of genetic diversity at MC4R in humans but not in chimpanzees.

hgdp-ceph germans central additional dhplc direct coding
Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions.

PMID 19772609 · PMC2759955 · BMC genetics · 2009 · 8 claims · 5 setups

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Saudi Arabia differs from other Arabian Peninsula countries by a significantly higher presence of J2-M172 lineages.

saudi same j1-m267 y-chromosome y-str amova
Analysis of concordance of different haplotype block partitioning algorithms.

PMID 16356172 · PMC1343594 · BMC bioinformatics · 2005 · 7 claims · 7 setups

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Each block partitioning algorithm infers blocks differing in number, size, and coverage under different SNP density and allele frequency conditions.

simulated subsamples coalescent diversity-based ld-based
Metatranscriptomics of the human oral microbiome during health and disease.

PMID 24692635 · PMC3977359 · mBio · 2014 · 8 claims · 8 setups

Has reproduction · 62

Disease-associated periodontal communities display conserved community-level metabolic gene expression profiles between patients, whereas the metabolic gene expression of individual species is highly variable between patients.

patient-matched subset health rna-seq rrna comparison metatranscriptomics
Resequencing PNMT in European hypertensive and normotensive individuals: no common susceptibilily variants for hypertension and purifying selection on intron 1.

PMID 17645789 · PMC1947951 · BMC medical genetics · 2007 · 7 claims · 7 setups

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Resequencing of PNMT found no common susceptibility variants that distinguish hypertensive from normotensive individuals

genomic pnmt promoter pcr population haplotype
How bacterial communities expand functional repertoires.

PMID 17238278 · PMC1750926 · PLoS biology · 2006 · 8 claims · 7 setups

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The human microbiome contains roughly 100 times as many genes as does the human genome

bacteroides distal interleukin-10-deficient macrophages transcriptional metagenomic microbiota
Candidates for Balancing Selection in Leishmania donovani Complex Parasites.

PMID 34865011 · PMC8717319 · Genome biology and evolution · 2021 · 7 claims · 8 setups

Has reproduction · 64

Five genetically distinct, well-sampled populations exist within the L. donovani complex: EA1, EA2 (East Africa), ISC1, ISC2 (Indian subcontinent), and BM (Brazil-Mediterranean)

infantum donovani snp populations whole-genome read admixture
Environment and Co-occurring Native Mussel Species, but Not Host Genetics, Impact the Microbiome of a Freshwater Invasive Species (Corbicula fluminea).

PMID 35444631 · PMC9014210 · Frontiers in microbiology · 2022 · 7 claims · 7 setups

Has reproduction · 55

The gut microbiome of C. fluminea is diverse, differs with environmental conditions, and varies spatially among rivers, but is unrelated to host genetic variation

corbicula six sediment filtered 16s radseq picrust2
Genetic affinities among the lower castes and tribal groups of India: inference from Y chromosome and mitochondrial DNA.

PMID 16893451 · PMC1569435 · BMC genetics · 2006 · 8 claims · 4 setups

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Mitochondrial DNA shows no significant difference between Indian tribal and caste populations except higher frequency of west Eurasian-specific haplogroups in upper castes, especially in northwest India

pardhan same comparative mtdna y-chromosome y-str
Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research.

PMID 17941974 · PMC2175509 · BMC genetics · 2007 · 8 claims · 7 setups

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SLC6A1 shows low levels of LD and an absence of major LD blocks across all five populations studied

african-american thai same study sanger snp genotyping
Constraints to gene flow increase the risk of genome erosion in the Ngorongoro Crater lion population.

PMID 40258987 · PMC12012037 · Communications biology · 2025 · 8 claims · 9 setups

Has reproduction · 68

200 years of quasi-isolation and the 1962 epizootic caused a two-fold increase in inbreeding and an excess of highly deleterious mutations in Crater lions relative to other Greater Serengeti populations

african lion crater simulated genome principal admixture
Population Genomic Analyses Suggest a Hybrid Origin, Cryptic Sexuality, and Decay of Genes Regulating Seed Development for the Putatively Strictly Asexual Kingdonia uniflora (Circaeasteraceae, Ranunculales).

PMID 36674965 · PMC9866071 · International journal of molecular sciences · 2023 · 8 claims · 8 setups

Has reproduction · 51

K. uniflora shows high allelic heterozygosity (negative F_IS) consistent with theoretical expectations under asexual evolution

uniflora whole-genome phylogenomic population

Experiments

Sex-biased evolutionary forces shape genomic patterns of human diversity.

Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.

Melanesian mtDNA complexity.

Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.

Inferring human colonization history using a copying model.

The detection of regions of our genome under selection has increasingly relied on the use of genome scans.

ddRAD-seq reveals the genetic structure and detects signals of selection in Italian brown trout.

Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region.

Increased constraints on MC4R during primate and human evolution.

Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions.

Analysis of concordance of different haplotype block partitioning algorithms.

Metatranscriptomics of the human oral microbiome during health and disease.

Resequencing PNMT in European hypertensive and normotensive individuals: no common susceptibilily variants for hypertension and purifying selection on intron 1.

How bacterial communities expand functional repertoires.

Candidates for Balancing Selection in Leishmania donovani Complex Parasites.

Environment and Co-occurring Native Mussel Species, but Not Host Genetics, Impact the Microbiome of a Freshwater Invasive Species (Corbicula fluminea).

Genetic affinities among the lower castes and tribal groups of India: inference from Y chromosome and mitochondrial DNA.

Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research.

Constraints to gene flow increase the risk of genome erosion in the Ngorongoro Crater lion population.

Population Genomic Analyses Suggest a Hybrid Origin, Cryptic Sexuality, and Decay of Genes Regulating Seed Development for the Putatively Strictly Asexual Kingdonia uniflora (Circaeasteraceae, Ranunculales).