Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter.

  PMID 38587191 · PMC11077057 · Nucleic acids research · 2024 · 6 claims · 8 setups

  Has reproduction · 68

  A dual fluorescence (GFP-mCherry) readthrough reporter with a PAS inserted between the two reporters enables measurement of 3' end processing efficiency in living cells.

  hek293 coli dual genome-wide western

• VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.

  PMID 41820368 · PMC13121600 · Nature communications · 2026 · 8 claims · 8 setups

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  CBFB (CBF-β) is a synthetic lethal interactor of VHL in ccRCC cell lines

  786o ccrcc tcga genome-wide competitive immunoblot

• Nanog mediated control of TBX3-GATA6 circuitry in primitive endoderm differentiation of mESCs.

  PMID 41629627 · PMC12979688 · EMBO reports · 2026 · 8 claims · 8 setups

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  NANOG partners with TBX3 and the PRC2 complex to maintain ESC identity by silencing PrE genes through distal enhancers

  rcnβh escs qpcr rna-seq chip-seq

• Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses.

  PMID 41813846 · PMC13083880 · The EMBO journal · 2026 · 8 claims · 8 setups

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  CAPN3 promotes rapid dissociation of PRC1 complexes from chromatin in response to stress

  hepatocytes liver doxycycline-inducible capn3 chip-seq cut&tag western

• Transcription elongation can be sufficient, but is not necessary, to advance replication timing.

  PMID 41876817 · PMC13121604 · EMBO reports · 2026 · 8 claims · 5 setups

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  Transcriptional elongation can causally advance RT in a rate-dependent and context-specific manner

  musculus same tre-ptn mesc repli-seq bru-seq genome-wide

• X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer.

  PMID 41922576 · PMC13099652 · Oncogene · 2026 · 8 claims · 8 setups

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  lncRNA1456, previously classified as noncoding, encodes a 132 amino acid protein named XCP (X-linked Cancer-associated Polypeptide)

  mcf-7 breast recombinant polya+ lc-ms race

• Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair.

  PMID 41844625 · PMC13250124 · NPJ Regenerative medicine · 2026 · 8 claims · 8 setups

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  Localized Wnt3a signaling asymmetrically distributes H3K14ac between daughter cells during hSSC asymmetric cell division (ACD), with the Wnt-proximal cell retaining high H3K14ac and higher transcriptional activity (RNApolS2P)

  skeletal hssc hsscs wiotm immunofluorescence tunel doxycycline-inducible