Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 16

System / cell line: wild-type ✕ Assay: drug ✕ Clear

Cancer biomarker AKR1B10 and carbonyl metabolism.

PMID 19028477 · PMC6193474 · Chemico-biological interactions · 2009 · 8 claims · 6 setups

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AKR1B10 reduces the anticancer drug daunorubicin to daunorubicinol, decreasing its chemotherapeutic effectiveness

recombinant fenofibrate enzyme sds-page x-ray
Utilization of genomic signatures to identify phenotype-specific drugs.

PMID 19714244 · PMC2729377 · PloS one · 2009 · 8 claims · 8 setups

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A RAS pathway gene expression signature applied to NCI-60 cells identifies compounds selectively active against RAS-activated cells, including the MEK inhibitor Hypothemycin

nci-60 breast mda-mb-231 signature-drug gene signature
Small molecule splicing modulators that disrupt O-GlcNAc homeostasis.

PMID 41526361 · PMC12894984 · Nature communications · 2026 · 8 claims · 7 setups

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Kinase inhibitors GSK690693 and Y-33075 act as splicing modulators that disrupt O-GlcNAc homeostasis by simultaneously downregulating both OGT and OGA

hct116 recombinant hek293t high-content western udp-glo
Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.

PMID 17318599 · PMC1915625 · Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2007 · 7 claims · 7 setups

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The T309V mutation shifts the CYP2D6 heme spin equilibrium toward the six-coordinate low-spin (6cLS) state, decreasing the five-coordinate high-spin (5cHS) fraction relative to wild type.

recombinant cyp2d6 computational resonance uv-vis sds-page
MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution.

PMID 33849057 · PMC8266615 · Nucleic acids research · 2021 · 8 claims · 7 setups

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MrHAMER yields >1000s of viral genomes per sample at 99.9% accuracy

psg3.1 transcribed double-stranded mrhamer transcription reverse mrhamer
Epimutations driven by RNAi or heterochromatin evoke transient antimicrobial drug resistance in pathogenic Mucor fungi.

PMID 41628159 · PMC12863538 · PLoS biology · 2026 · 8 claims · 8 setups

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In M. bainieri, most (90%) FK506-resistant isolates are unstable/transient and revert to drug sensitivity without any detectable DNA mutation

mucor fk506-resistant bainieri drug sanger serial
A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells.

PMID 34316714 · PMC8271219 · NAR cancer · 2021 · 7 claims · 8 setups

Has reproduction · 85

EMT and tamoxifen-resistance (TamR) regulatory axes can drive one another, enabling non-genetic heterogeneity via six co-existing phenotypes (ES, ER, HS, HR, MS, MR)

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Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp.

PMID 17106442 · PMC2360739 · British journal of cancer · 2006 · 5 claims · 4 setups

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NSCLC patients with EGFR mutations detected by PNA-LNA PCR clamp show significantly higher response rates and longer survival with gefitinib than EGFR wild-type patients.

clinical nsclc pna-lna direct phase
Chemical genomics: what will it take and who gets to play?

PMID 11423004 · PMC138939 · Genome biology · 2001 · 8 claims · 8 setups

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Scaling chemical genetics to a genome-wide 'chemical genomics' requires large, well-funded, multidisciplinary centers that integrate compound libraries, protein resources, automation, and profiling technology, and freely distribute data and reagents.

iccb fluorescently yeast engineered cell-based small-molecule expression
Activating mutations in ALK provide a therapeutic target in neuroblastoma.

PMID 18923525 · PMC2587486 · Nature · 2008 · 8 claims · 8 setups

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Non-synonymous ALK kinase domain mutations occur in 8% of primary neuroblastomas, with F1174L being the most frequent

neuroblastoma kelly fish sequencing cytokine-independence
Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line.

PMID 8382508 · PMC1968246 · British journal of cancer · 1993 · 8 claims · 5 setups

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CEM/VP-1 is 15-fold more resistant to etoposide than parental CCRF-CEM cells

ccrf-cem cem nuclear cytogenetic pcr allele-specific
Searching for genes underlying behavior: lessons from circadian rhythms.

PMID 18988844 · PMC3744585 · Science (New York, N.Y.) · 2008 · 8 claims · 5 setups

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Forward genetic mutagenesis screens successfully identified the molecular components of the circadian clock across Drosophila, Neurospora, cyanobacteria, Arabidopsis, and mouse.

c57bl genomic automated contextual psychostimulant-induced
FRMD8 inhibits tumor metastasis in BRCA1-associated TNBC by negatively regulating tmTNF-α.

PMID 40619383 · PMC12229025 · Cellular & molecular biology letters · 2025 · 8 claims · 8 setups

Has reproduction · 73

Low FRMD8 expression in BRCA1-mutant breast cancer cells significantly enhances metastatic potential to various organs

tnbc geo breast frmd8 bulk meta-analysis single-cell
PALB2 variants in hereditary and unselected Finnish prostate cancer cases.

PMID 20003494 · PMC2806404 · Journal of negative results in biomedicine · 2009 · 8 claims · 6 setups

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None of the detected PALB2 variants, including 1592delT, show significant association with PRCA at the population level in Finland

blood finnish combined formalin-fixed direct additional statistical
A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data.

PMID 19923232 · PMC2817484 · Nucleic acids research · 2010 · 8 claims · 7 setups

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A Perl-based pipeline that BLASTs/BLATs Illumina probe sequences against genomes and transcript databases (RefSeq, UCSC Known Genes, UniGene/GenBank, Ensembl) can classify probes by quality grade (Perfect/Good/Bad/No match) and is applicable across 8 BeadArray platforms and other array types

maqc hepatocytes japanese illeum microarray dasl sequence
Holliday junction recognition protein (HJURP) could reflect the clinical outcomes of lung adenocarcinoma patients, and impact the choice of precision therapy.

PMID 39649097 · PMC11621083 · Frontiers in genetics · 2024 · 7 claims · 8 setups

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HJURP is a significant prognostic biomarker in LUAD, with high expression associated with increased risk of overall survival death across four independent cohorts

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Experiments

Cancer biomarker AKR1B10 and carbonyl metabolism.

Utilization of genomic signatures to identify phenotype-specific drugs.

Small molecule splicing modulators that disrupt O-GlcNAc homeostasis.

Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.

MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution.

Epimutations driven by RNAi or heterochromatin evoke transient antimicrobial drug resistance in pathogenic Mucor fungi.

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells.

Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp.

Chemical genomics: what will it take and who gets to play?

Activating mutations in ALK provide a therapeutic target in neuroblastoma.

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line.

Searching for genes underlying behavior: lessons from circadian rhythms.

FRMD8 inhibits tumor metastasis in BRCA1-associated TNBC by negatively regulating tmTNF-α.

PALB2 variants in hereditary and unselected Finnish prostate cancer cases.

A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data.

Holliday junction recognition protein (HJURP) could reflect the clinical outcomes of lung adenocarcinoma patients, and impact the choice of precision therapy.