Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Capsular specificity in temperate phages of Klebsiella pneumoniae is driven by diverse receptor-binding enzymes.

  PMID 42048315 · PMC13123978 · PLoS biology · 2026 · 8 claims · 5 setups

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  Capsular specificity in temperate K. pneumoniae phages is driven by structurally diverse prophage-encoded receptor-binding enzymes, including classical β-helix depolymerases, SGNH-domain hydrolases, and structurally novel RBPs.

  klebsiella candidate genome-wide prophage capsular

• scTWAS: a powerful statistical framework for single-cell transcriptome-wide association studies.

  PMID 41820391 · PMC13121454 · Nature communications · 2026 · 8 claims · 5 setups

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  scTWAS uses a latent-variable expression-measurement model combined with a moment-based regression to more accurately estimate genetic regulation of gene expression from single-cell data, improving GReX prediction across cell types and datasets

  onek1k-derived onek1k-based immune brain simulated two-sample stage

• Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing.

  PMID 31443728 · PMC6708158 · Genome medicine · 2019 · 6 claims · 8 setups

  Has reproduction · 68

  A near-perfect chronological age predictor can in principle be developed from DNA methylation when training sample size is sufficiently large.

  blood unrelated sgpd lbc1921 methylation reml permutation

• Protocol to perform cell-type-specific transcriptome-wide association study using scPrediXcan framework.

  PMID 41689808 · PMC12925207 · STAR protocols · 2026 · 6 claims · 6 setups

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  scPrediXcan enables cell-type-specific transcriptome-wide association studies (TWAS) by integrating deep learning-based prediction of gene expression from DNA sequence and epigenetic features.

  acinar individual-level geuvadis beta mlp-based personalized elastic-net

• Critical evaluation of drug response prediction models with DrEval.

  PMID 42120410 · PMC13168506 · Nature communications · 2026 · 8 claims · 6 setups

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  DrEval is a living open-source benchmarking pipeline for unbiased, biologically meaningful evaluation of cancer drug response prediction models, integrating standardized preprocessing, hyperparameter tuning, statistically rigorous evaluation, cross-study benchmarks, and ablation studies.

  ctrpv2 ccle beataml2 pdx_bruna viability drug pdx

• Machine learning-driven transcriptomic and single-cell profiling of programed cell death patterns in colon cancer.

  PMID 41854308 · PMC13009810 · Science progress · 2026 · 8 claims · 8 setups

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  Disulfidptosis and anoikis are consistently identified as the most robust prognostic PCD patterns in colon cancer across six independent machine learning algorithms

  colon coad ssgsea-based machine differential

• Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians.

  PMID 42030936 · PMC13198318 · Cell reports. Medicine · 2026 · 8 claims · 6 setups

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  LLIs exhibit a transcriptional age younger than expected for their chronological age, as measured by clocks trained on younger controls (YCs).

  peripheral european same age-related bulk gene machine

• SpaPheno: linking spatial transcriptomics to clinical phenotypes with interpretable machine learning.

  PMID 41975540 · PMC13185361 · Genome medicine · 2026 · 8 claims · 8 setups

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  SpaPheno integrates spatial transcriptomics with clinically annotated bulk RNA-seq to identify spatially resolved biomarkers predictive of patient outcomes including survival, tumor stage, and immunotherapy response

  cortex liver clear breast spatial elastic

• Glioblastoma stem cells show transcriptionally correlated spatial organization.

  PMID 41577992 · PMC12894897 · Communications biology · 2026 · 8 claims · 5 setups

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  GSCs from different patient samples exhibit diverse, characteristic multicellular spatial patterns in culture (e.g., anisotropic vs isotropic packing, overlapping vs non-overlapping space utilization)

  patient-derived computational matched pooled phase-contrast bulk principal

• Integrative transcriptomic and machine learning framework reveals candidate genes and potential mechanisms of aflatoxin B1 exposure in breast cancer.

  PMID 41688730 · PMC12982753 · Scientific reports · 2026 · 7 claims · 8 setups

  Has reproduction · 83

  170 unique human AFB1 targets were identified by merging ChEMBL, SwissTargetPrediction, and PharmMapper predictions

  afb1 breast training candidate computational bulk weighted