Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Fucosylated glycoproteins as markers of liver disease.

  PMID 19126969 · PMC3827789 · Disease markers · 2008 · 8 claims · 6 setups

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  Core alpha 1,6-linked fucosylation of AFP (AFP-L3) is increased in HCC and is a more specific marker of HCC than total AFP

  afp pooled larger igg lectin fucose-specific immunoblot

• The oxazolidinone derivative locostatin induces cytokine appeasement.

  PMID 19917702 · PMC2799496 · Journal of immunology (Baltimore, Md. : 1950) · 2009 · 7 claims · 7 setups

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  RKIP is differentially localized (not differentially expressed) on the proteomic map after in vivo T cell recall compared to resting state

  ot-i splenocytes fractions serum intracellular proteomics sds-page

• Update on diabetes mellitus.

  PMID 15502249 · PMC3839330 · Disease markers · 2004 · 8 claims · 7 setups

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  Type 1 diabetes results from selective destruction of pancreatic beta cells via T-cell and cytokine mediated autoimmune mechanisms, possibly involving destruction of peri-islet Schwann cells.

  nod t1dm islets 3t3-l1 seldi-tof tof two-dimensional

• Proteomics approaches to identify tumor antigen directed autoantibodies as cancer biomarkers.

  PMID 15502247 · PMC3839398 · Disease markers · 2004 · 8 claims · 8 setups

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  Proteomics approaches (2D Western blot, protein microarray, multiplex ELISA) can identify tumor antigen-directed autoantibodies as candidate cancer biomarkers

  lung pancreatic hepatocellular renal gel microarray multiplex

• Use of proteomics for validation of the isolation process of clotting factor IX from human plasma.

  PMID 19819359 · PMC2818390 · Journal of proteomics · 2010 · 8 claims · 8 setups

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  Proteomic techniques (LC-MS/MS, iTRAQ, immunochemical/biochemical methods) can monitor and validate each production step of pd F IX isolation

  plasma in-process chromatographic one-stage competitive elisa

• Proteomic approaches to cancer biomarkers.

  PMID 19931265 · PMC2873613 · Gastroenterology · 2010 · 8 claims · 8 setups

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  Combining abundant-protein depletion, offline fractionation, and subproteome (e.g., glycoproteome) enrichment with 2D LC-MS/MS increases the dynamic range and depth of blood proteome analysis for biomarker discovery.

  plasma serum capan-2 apcδ580 lectin silac elisa

• Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.

  PMID 32959884 · PMC7689298 · Human molecular genetics · 2020 · 8 claims · 8 setups

  Has reproduction · 67

  Trem2 promotes/drives the IL-4-induced anti-inflammatory gene expression program (e.g. Arg1, Ap1b1) in microglia, and reduced Trem2 attenuates this response.

  hippocampal microglia microglial rt-qpcr immunohistochemistry microglial

• Characterization of the placental macrophage secretome: implications for antiviral activity.

  PMID 19070362 · PMC2947718 · Placenta · 2009 · 7 claims · 5 setups

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  PM and MDM secrete different soluble proteins, some of which may contribute to decreased HIV-1 replication in PM

  placental seldi-tof sds-page western

• A homozygous CARD9 mutation in a family with susceptibility to fungal infections.

  PMID 19864672 · PMC2793117 · The New England journal of medicine · 2009 · 7 claims · 7 setups

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  A homozygous CARD9 point mutation (Q295X, premature termination codon) is associated with autosomal recessive susceptibility to chronic mucocutaneous candidiasis.

  family patients peripheral-blood peripheral snp microsatellite sanger