Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 16

System / cell line: cell-type ✕ Assay: elisa ✕ Clear

A new mRNA antigen vaccine induces potent B and T cell responses and in vivo protection against SARS-CoV-2.

PMID 41876554 · PMC13172340 · NPJ vaccines · 2026 · 8 claims · 8 setups

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The G1-C mRNA vaccine (RBD + membrane protein epitope) induces 8.2-fold higher WA1 RBD-specific IgG and 16.6-fold higher XBB.1.5 RBD-specific IgG than the RBD-only vaccine

plasma pbmcs spleen bone elisa pseudovirus intracellular
Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson's disease.

PMID 38566100 · PMC10985960 · Cell communication and signaling : CCS · 2024 · 8 claims · 8 setups

Has reproduction · 55

Microglia, endothelial cells, and pericytes exhibit the highest IFN-I activity among PD midbrain cell types, with microglia and endothelial cells showing significantly elevated high-IFN-I-scoring proportions in PD versus controls

midbrain single microglia substantia single-cell scenic monocle
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.

PMID 40204713 · PMC11982250 · Nature communications · 2025 · 8 claims · 7 setups

Has reproduction · 91

GRAMD1B is increased in excitatory neurons of human neural organoids (HNOs) carrying the MAPT R406W mutation

neural hno single-cell immunofluorescence western
Berberine suppresses colon inflammation via integrated modulation of host metabolism, microbial ecology, and innate immune signaling.

PMID 41356191 · PMC12680593 · Theranostics · 2026 · 6 claims · 8 setups

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Berberine enhances energy metabolism (oxidative phosphorylation, ATP biosynthesis, fatty acid metabolism) in intestinal epithelial cells of DSS-induced mice, preserving normal physiological function

colon feces serum dss-induced single-cell targeted 16s
Target cell APOBEC3C can induce limited G-to-A mutation in HIV-1.

PMID 17967058 · PMC2042017 · PLoS pathogens · 2007 · 8 claims · 8 setups

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APOBEC3C is necessary and sufficient to induce G-to-A mutation in some HIV-1 strains despite Vif expression

magi pbmc 293t supt1 sensitive rt-pcr western
PD-1 blockade plus tyrosine kinase inhibitor remodels the tumor microenvironment in advanced renal cell carcinoma.

PMID 41916996 · PMC13199584 · Nature communications · 2026 · 8 claims · 8 setups

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Non-responders to TKI±ICI therapy show increased neutrophil infiltration and enrichment of SAA+ tumor cells after treatment.

arcc pre post-treatment tumor single-cell multiplex ligand-receptor
Single-cell transcriptomics identifies regulatory T cell heterogeneity in gestational diabetes mellitus.

PMID 41933176 · PMC13223204 · Communications medicine · 2026 · 8 claims · 8 setups

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Treg cluster proportions do not significantly differ between GDM and healthy control patients

sorted pbmcs treg gdm-patient single-cell mass gene
Single-cell dissection of regulated cell death dynamics in ovarian aging.

PMID 41689119 · PMC13005338 · Journal of ovarian research · 2026 · 8 claims · 8 setups

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The RCD landscape of ovarian aging had not previously been characterized at single-cell resolution

ovary serum scrna-seq bulk single-nucleus
Multi-Omic Profiling of T Cell-Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance.

PMID 41467897 · PMC12752722 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · 8 claims · 8 setups

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The BCR repertoire, particularly the IgG isotype, is significantly expanded in TCMR compared to stable renal function (STA) across independent renal transplant cohorts

kidney healthy lp-1 bcr bulk triple
Tenascin C(+) myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice.

PMID 41617709 · PMC12960667 · Nature communications · 2026 · 7 claims · 8 setups

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A distinct population of Tnc+ myofibroblasts (cluster iFb5) emerges from adventitial fibroblasts during ligation-induced neointimal hyperplasia

carotid adventitial pdgfrα nih-3t3 scrna-seq spatial immunofluorescence
Oxidative stress-associated genes TPPP3 and VEGFA in COPD revealed by bulk and single-cell sequencing analysis.

PMID 41620539 · PMC12916760 · Scientific reports · 2026 · 8 claims · 9 setups

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76 overlapping genes were identified between COPD-associated DEGs and oxidative stress-related genes.

lung genecards differentially bronchial bulk database functional
Dopamine enhances surface glial glycolysis via acetylcholine and insulin/insulin-like growth factor signaling in the honeybee.

PMID 41797926 · PMC12964235 · iScience · 2026 · 8 claims · 5 setups

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Bromocriptine (dopamine receptor agonist) increases glycolytic flux in forager bee brains

forager targeted qpcr single-cell
Alternative polyadenylation mediated the downregulation of lysophosphatidylglycerol acyltransferase 1 in metabolic dysfunction-associated steatotic liver disease.

PMID 41507908 · PMC12879358 · Lipids in health and disease · 2026 · 8 claims · 8 setups

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Early hepatocyte-specific APA remodeling, characterized by 3' UTR lengthening of metabolism-related genes (especially LPGAT1), occurs in MASLD and is established before fibrosis progression

liver hepg2 293t serum bulk single-cell oil
Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.

PMID 41680858 · PMC12910993 · Journal of translational medicine · 2026 · 8 claims · 8 setups

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IL4I1 mRNA expression is significantly elevated in AML compared to normal controls

tcga-laml bone thp-1-derived thp-1 bulk kaplan-meier deg
Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation.

PMID 41912493 · PMC13039830 · Translational psychiatry · 2026 · 8 claims · 8 setups

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571 shared targets identified between BPA-associated (2554) and MDD-associated (4661) genes

gene shared gwas gabaergic network ppi mendelian
Multi-omics integration and machine learning reveal gut-immune signatures in idiopathic pulmonary fibrosis: insights from bulk RNA-seq, single-cell profiles, spatial transcriptomics, and experimental validation.

PMID 41939867 · PMC13043422 · Frontiers in immunology · 2026 · 7 claims · 8 setups

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CXCL13, IL33, TLR4, and IGF1 are core IPF genes consistently linked to immune infiltration and fibrotic remodeling across bulk, single-cell, spatial, and blood multi-omics data

lung candidate bulk normalized bulk ppi machine

Experiments

A new mRNA antigen vaccine induces potent B and T cell responses and in vivo protection against SARS-CoV-2.

Single cell analysis reveals the roles and regulatory mechanisms of type-I interferons in Parkinson's disease.

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.

Berberine suppresses colon inflammation via integrated modulation of host metabolism, microbial ecology, and innate immune signaling.

Target cell APOBEC3C can induce limited G-to-A mutation in HIV-1.

PD-1 blockade plus tyrosine kinase inhibitor remodels the tumor microenvironment in advanced renal cell carcinoma.

Single-cell transcriptomics identifies regulatory T cell heterogeneity in gestational diabetes mellitus.

Single-cell dissection of regulated cell death dynamics in ovarian aging.

Multi-Omic Profiling of T Cell-Mediated Rejection After Kidney Transplantation Reveals B Cell Receptor Repertoire Expansion and Its Prognostic Relevance.

Tenascin C(+) myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice.

Oxidative stress-associated genes TPPP3 and VEGFA in COPD revealed by bulk and single-cell sequencing analysis.

Dopamine enhances surface glial glycolysis via acetylcholine and insulin/insulin-like growth factor signaling in the honeybee.

Alternative polyadenylation mediated the downregulation of lysophosphatidylglycerol acyltransferase 1 in metabolic dysfunction-associated steatotic liver disease.

Increased IL4I1 expression predicts poor survival and modulates the immune microenvironment in acute myeloid leukemia.

Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation.

Multi-omics integration and machine learning reveal gut-immune signatures in idiopathic pulmonary fibrosis: insights from bulk RNA-seq, single-cell profiles, spatial transcriptomics, and experimental validation.