Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

Publications 1.3k Datasets 392.5k Experiments 24

System / cell line: relative ✕ Assay: elisa ✕ Clear

Proteomic analyses of monocyte-derived macrophages infected with human immunodeficiency virus type 1 primary isolates from Hispanic women with and without cognitive impairment.

PMID 19115125 · PMC2947716 · Journal of neurovirology · 2009 · 7 claims · 5 setups

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HIV-1 isolates from CI patients induce a distinct macrophage proteome signature compared to isolates from NC patients and SF162

monocyte-derived mdm mdms western p24 seldi-tof sds-page
A rational approach for discovering and validating cancer markers in very small samples using mass spectrometry and ELISA microarrays.

PMID 15502246 · PMC3839270 · Disease markers · 2004 · 8 claims · 4 setups

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A two-stage strategy combining MS proteomics for discovery and ELISA microarrays for validation can identify and characterize cancer markers in very small samples

complex naf minute clc-fticr tandem elisa
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry.

PMID 19012186 · PMC3163445 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008 · 8 claims · 6 setups

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Amniotic fluid protein composition can be analyzed by combining 2D liquid chromatography and mass spectrometry to identify differentially expressed proteins in preterm labor

pooled amniotic two-dimensional sds-page maldi-tof
Mass spectrometry-based biomarker discovery: toward a global proteome index of individuality.

PMID 20636062 · PMC3140421 · Annual review of analytical chemistry (Palo Alto, Calif.) · 2009 · 8 claims · 4 setups

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Very few large-scale longitudinal MS-based proteomics studies have been performed to establish analytical variability relative to true biological variability.

normal plasma longitudinal bottom-up top-down
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.

PMID 32959884 · PMC7689298 · Human molecular genetics · 2020 · 8 claims · 8 setups

Has reproduction · 67

Trem2 promotes/drives the IL-4-induced anti-inflammatory gene expression program (e.g. Arg1, Ap1b1) in microglia, and reduced Trem2 attenuates this response.

hippocampal microglia microglial rt-qpcr immunohistochemistry microglial
mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft.

PMID 18980691 · PMC2612029 · BMC genomics · 2008 · 8 claims · 8 setups

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mtDNA depletion confers specific, shared gene expression profiles in A549 cells grown in culture and as xenografts

a549 growth oxygen mtdna
Biomarker discovery in neurodegenerative diseases: a proteomic approach.

PMID 18938247 · PMC2939006 · Neurobiology of disease · 2009 · 6 claims · 8 setups

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Proteomic profiling of CSF and plasma can identify candidate protein biomarkers that distinguish AD patients from controls with high sensitivity and specificity

csf plasma brain 2-dge lc-ms seldi-tof-ms
Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo.

PMID 18651708 · PMC2699546 · Proteomics · 2008 · 8 claims · 6 setups

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A dermis-based cell-trapped system (DBCTS) with human sebocytes inserted into a subcutaneous tissue chamber creates a humanized acne microenvironment in mice

chamber infiltrated de-epidermized sebocyte cfu sandwich immunofluorescence
Global proteome analysis of Leptospira interrogans.

PMID 19663501 · PMC2757032 · Journal of proteome research · 2009 · 8 claims · 5 setups

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563 proteins were identified in L. interrogans via combined iTRAQ and 2DGE proteomic analysis

leptospira serum liver itraq two-dimensional immunoblot
A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver disease.

PMID 19656391 · PMC2729079 · BMC cancer · 2009 · 8 claims · 4 setups

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2D gel proteomic profiling of immunodepleted serum reveals protein spot patterns that differentiate pre-cirrhotic NAFLD, cirrhotic NAFLD, and cirrhotic NAFLD with HCC

immunodepleted serum liver gel direct semi-quantitative
Screening of Diagnostic Biomarkers and Immune Infiltration Characteristics Linking Rheumatoid Arthritis and Rosacea Based on Bioinformatics Analysis.

PMID 39104909 · PMC11299729 · Journal of inflammation research · 2024 · 8 claims · 8 setups

Has reproduction · 48

277 co-expressed DEGs shared between RA and rosacea are enriched in immune processes and chemokine-mediated signaling pathways

synovial rosacea co-expressed serum microarray weighted protein-protein
A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes.

PMID 9449708 · PMC2212124 · The Journal of experimental medicine · 1998 · 8 claims · 8 setups

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A gene, SART-1, encoding antigenic peptides recognized by HLA-A2601-restricted CTLs was identified from human squamous cell carcinoma cells.

ke4 normal pbmcs va13 expression northern western
Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics.

PMID 17331236 · PMC1868942 · Genome biology · 2007 · 8 claims · 8 setups

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moDCs and KG-1 cells show significant proteomic differences from primary mDCs, particularly in proteins involved in cell growth/maintenance and cell-cell interaction/integrity.

mdcs mdc freshly peripheral two-dimensional maldi-tof capture
The current state of proteomics in GI oncology.

PMID 19104933 · PMC3045515 · Digestive diseases and sciences · 2009 · 8 claims · 8 setups

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More than 130 exploratory proteomic studies have defined candidate biomarkers in serum, GI fluids, or cancer tissue for GI oncology

serum laser-capture-microdissected seldi-ms 2-de antibody
Salivary proteomics for oral cancer biomarker discovery.

PMID 18829504 · PMC2877125 · Clinical cancer research : an official journal of the American Association for Cancer Research · 2008 · 8 claims · 5 setups

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Subtractive salivary proteomics reveals proteins differentially present/expressed between OSCC patients and matched healthy controls.

pooled saliva shotgun two-dimensional elisa
Use of proteomics for validation of the isolation process of clotting factor IX from human plasma.

PMID 19819359 · PMC2818390 · Journal of proteomics · 2010 · 8 claims · 8 setups

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Proteomic techniques (LC-MS/MS, iTRAQ, immunochemical/biochemical methods) can monitor and validate each production step of pd F IX isolation

plasma in-process chromatographic one-stage competitive elisa
Proteomic characterization of plasma-derived clotting factor VIII-von Willebrand factor concentrates.

PMID 19768705 · PMC3030255 · Electrophoresis · 2009 · 8 claims · 8 setups

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Commercial plasma-derived FVIII/VWF concentrates contain significant amounts of non-FVIII/VWF plasma proteins as impurities

plasma-derived octanate sec fviii sds-page size-exclusion lc-esi-ms
Polymorphism and epitope sharing between the alleles of merozoite surface protein-1 of Plasmodium falciparum among Indian isolates.

PMID 17659072 · PMC1950510 · Malaria journal · 2007 · 7 claims · 6 setups

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PfMAD20 is the predominant PfMSP-1 allelic type among Indian field isolates

falciparum escherichia coli-expressed recombinant pcr recombinant sds-page
Characterization of the placental macrophage secretome: implications for antiviral activity.

PMID 19070362 · PMC2947718 · Placenta · 2009 · 7 claims · 5 setups

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PM and MDM secrete different soluble proteins, some of which may contribute to decreased HIV-1 replication in PM

placental seldi-tof sds-page western
The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.

PMID 18726985 · PMC2826114 · The Prostate · 2008 · 7 claims · 8 setups

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Quercetin treatment of prostate cancer cells decreases cell proliferation and viability in a dose-dependent manner

pc-3 excised prostate viability difference nano

Experiments

Proteomic analyses of monocyte-derived macrophages infected with human immunodeficiency virus type 1 primary isolates from Hispanic women with and without cognitive impairment.

A rational approach for discovering and validating cancer markers in very small samples using mass spectrometry and ELISA microarrays.

Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry.

Mass spectrometry-based biomarker discovery: toward a global proteome index of individuality.

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.

mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft.

Biomarker discovery in neurodegenerative diseases: a proteomic approach.

Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo.

Global proteome analysis of Leptospira interrogans.

A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver disease.

Screening of Diagnostic Biomarkers and Immune Infiltration Characteristics Linking Rheumatoid Arthritis and Rosacea Based on Bioinformatics Analysis.

A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes.

Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics.

The current state of proteomics in GI oncology.

Salivary proteomics for oral cancer biomarker discovery.

Use of proteomics for validation of the isolation process of clotting factor IX from human plasma.

Proteomic characterization of plasma-derived clotting factor VIII-von Willebrand factor concentrates.

Polymorphism and epitope sharing between the alleles of merozoite surface protein-1 of Plasmodium falciparum among Indian isolates.

Characterization of the placental macrophage secretome: implications for antiviral activity.

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.