Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Single-Nucleus Multi-Omics Reveals Hypoxia-Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma.

  PMID 41498635 · PMC12948189 · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026 · 8 claims · 8 setups

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  Five distinct malignant cell populations exist in SNSCC, with hypoxic (TC1) and proliferative (TC2) subtypes associated with adverse clinical outcomes.

  snscc bulk single-nucleus bulk single-nucleus methylation

• Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.

  PMID 41850280 · PMC13103949 · Cell reports · 2026 · 8 claims · 8 setups

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  Chemotherapy-resistant KT-47R tumors show blastemal predominance and reduced stromal content compared to pre-treatment KT-47PT

  kt-47 kt-47pt histology whole-exome cut&tag

• A cellular epigenetic classification system for glioblastoma.

  PMID 41499453 · PMC13128495 · Neuro-oncology · 2026 · 8 claims · 8 setups

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  ITHresolveGBM, a hierarchical two-step NMF method, deconvolutes bulk GBM DNA methylation profiles into three non-malignant (immune, glial, neuronal) and three malignant components

  gbm healthy pseudo-bulk tcga illumina single-cell deconvolution

• DNA methylation biomarkers-based pan-cancer classifier: predictive modeling for cancer classification.

  PMID 42152108 · PMC13185202 · Genome medicine · 2026 · 8 claims · 5 setups

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  Relatively simple ML models (logistic regression) outperform complex algorithms such as deep neural networks for methylation-based cancer classification

  validation cns healthy genes methylation copy-number gene-set

• Epigenomic, transcriptomic, and proteomic characterization of breast cancer cell line reference samples.

  PMID 41539304 · PMC12853167 · Cell reports methods · 2026 · 8 claims · 5 setups

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  Comprehensive multi-omics reference materials (ATAC-seq, Methyl-seq, RNA-seq, MS-proteomics) were generated for paired HCC1395/HCC1395BL cell lines as a community benchmarking resource

  hcc1395 atac-seq methyl-seq bulk

• 5-methylcytosine RNA modification regulators-based patterns and features of immune microenvironment in acute myeloid leukemia.

  PMID 38277218 · PMC10911375 · Aging · 2024 · 8 claims · 8 setups

  Has reproduction · 93

  m5C regulators are differentially expressed between AML and normal samples and correlate with AML prognosis

  tcga aml gse12417 bulk mutation methylation

• GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer.

  PMID 42050691 · PMC13126711 · Clinical epigenetics · 2026 · 8 claims · 8 setups

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  GLYATL1 expression is upregulated in AI-resistant breast cancer cell models and in patients undergoing AI therapy

  mcf7 lysates rna-sequencing atac-sequencing epic