Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Proteomics of the human malaria parasite Plasmodium falciparum.
PMID 16445353 · PMC2721975 · Expert review of proteomics · 2006 · 8 claims · 8 setups
Completion of the P. falciparum genome sequence together with advances in mass spectrometry has enabled large-scale proteomic analysis of the parasite that was previously limited by inability to identify proteins from 2D gels
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Involvement of potential pathways in malignant transformation from oral leukoplakia to oral squamous cell carcinoma revealed by proteomic analysis.
PMID 19691830 · PMC2746235 · BMC genomics · 2009 · 7 claims · 6 setups
85 proteins are differentially and consistently expressed (>2-fold change, P<0.05) between paired OLK and OSCC tissues, including 52 up-regulated and 33 down-regulated proteins
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A European focus on proteomics.
PMID 15128441 · PMC416463 · Genome biology · 2004 · 8 claims · 8 setups
MALDI-MS and ESI-MS are complementary techniques that identify overlapping but distinct subsets of proteins
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System-based proteomic analysis of the interferon response in human liver cells.
PMID 15287976 · PMC507879 · Genome biology · 2004 · 7 claims · 4 setups
ICAT-based quantitative proteomics identified 1,364 proteins in Huh7 cells at <5% false-positive rate, with 54 induced and 24 repressed >2-fold by IFN treatment
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Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.
PMID 19833877 · PMC2797941 · Diabetes · 2010 · 7 claims · 5 setups
Mitochondrial protein abundance is decreased in insulin-resistant (obese and type 2 diabetic) skeletal muscle
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In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS.
PMID 19764811 · PMC2783959 · Journal of proteome research · 2009 · 8 claims · 6 setups
This is the first large-scale in vivo phosphoproteomic study of human skeletal muscle
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Lipids join the post-genomic era.
PMID 17076911 · PMC1794566 · Genome biology · 2006 · 8 claims · 8 setups
Infrared-laser MALDI-MS can image biological tissue while avoiding the matrix-preparation artifacts of UV-laser MALDI
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Proteomic analysis of aqueous humor from patients with myopia.
PMID 18334949 · PMC2268849 · Molecular vision · 2008 · 7 claims · 6 setups
Total protein concentration in AH is significantly greater in high myopia patients than in non-myopic controls
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Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
PMID 15642101 · PMC549070 · Genome biology · 2005 · 8 claims · 4 setups
PeptideAtlas, a public database integrating MS/MS-derived peptide identifications with the human genome, was built as an expandable resource for proteomic data.
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Proteomics of human neurodegenerative diseases.
PMID 18800015 · PMC2710115 · Journal of neuropathology and experimental neurology · 2008 · 8 claims · 8 setups
Proteomic techniques applied to autopsy brain and CSF from patients with neurodegenerative diseases provide insight into pathogenesis and enable biomarker discovery
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Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases.
PMID 19763266 · PMC2740864 · PloS one · 2009 · 8 claims · 8 setups
Androgen treatment alters the whole-cell proteome of LNCaP prostate cancer cells
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Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods.
PMID 16410651 · PMC3851111 · Disease markers · 2006 · 8 claims · 3 setups
Lipids comprise the bulk of the dry mass of the brain and serve structural, insulating, energy-storage, and signaling/inflammatory-mediator roles.
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Comparison of multidimensional shotgun technologies targeting tissue proteomics.
PMID 19960471 · PMC3465977 · Electrophoresis · 2009 · 6 claims · 4 setups
CITP-based multidimensional separation achieves superior overall proteome performance (more total peptide, distinct peptide, and distinct protein identifications) than SCX/MuDPIT under matched conditions
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Proteomic approaches for studying alcoholism and alcohol-induced organ damage.
PMID 23584750 · PMC3860448 · Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2008 · 8 claims · 7 setups
Chronic alcohol abuse produces persistent changes in brain function (tolerance, dependence, craving) likely resulting from alterations in gene and protein expression
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Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients.
PMID 15312778 · PMC7127270 · Journal of molecular biology · 2004 · 8 claims · 7 setups
ORF3a of SARS-CoV encodes an actual 31 kDa, 274-residue protein detected in infected cells and virions
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Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.
PMID 19784376 · PMC2747018 · PloS one · 2009 · 8 claims · 8 setups
Native human U1 snRNP shows differential incorporation of four protein isoforms (U1-70k isoforms 1/2, Sm-B/B')
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Proteomics in alcohol research.
PMID 12875051 · PMC6683837 · Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2002 · 7 claims · 8 setups
The proteome is larger and more complex than the genome due to differential splicing, post-translational modifications (PTMs), and protein-protein interactions.