Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models.
PMID 41912536 · PMC13172322 · Nature communications · 2026 · 8 claims · 8 setups
ACT with TCR-transgenic (OTI) CD8+ T cells eradicates established B16F10-OTI tumors and expands host CD8+ T cells with tumor-reactive (PD-1+GzmB-/PD-1+GzmB+, Tpex/Tex) and tissue-resident phenotypes
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Has reproduction · 81
Deubiquitination enzyme USP35 negatively regulates MAVS signaling to inhibit anti-tumor immunity.
PMID 40016186 · PMC11868397 · Cell death & disease · 2025 · 8 claims · 8 setups
USP35 interacts with MAVS and removes its K63-linked polyubiquitin chains, inhibiting viral-induced MAVS-TBK1-IRF3 activation and downstream inflammatory gene expression
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Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.
PMID 41735308 · PMC13043769 · Nature communications · 2026 · 8 claims · 8 setups
OSGEP is the catalytic subunit of the KEOPS complex responsible for t6A modification at position 37 of cytoplasmic tRNAs, and its loss causes the highest protein aggregation among 45 screened tRNA-modifying enzymes in melanoma cells
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SPP1(+) macrophage-driven interactions shape the tumor microenvironment in lymph node metastatic acral melanoma.
PMID 42020397 · PMC13230793 · Cell death & disease · 2026 · 8 claims · 8 setups
LN+ acral melanoma shows preferential SPP1+ signaling, including autocrine amplification within SPP1+ macrophages and paracrine interaction with S100A8+ melanoma cells via the SPP1-CD44 axis