Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Decoding drug-responsive cell subpopulations in triple-negative breast cancer using single-cell multiomics.

  PMID 42088352 · PMC13138057 · iScience · 2026 · 8 claims · 8 setups

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  A multimodal framework bridging bulk and single-cell transcriptomics data identifies drug-responsive cell subpopulations in TNBC

  tnbc tcga mdamb453 hcc1937 bulk scrna-seq crispr

• SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.

  PMID 41807550 · PMC13249849 · NPJ precision oncology · 2026 · 8 claims · 8 setups

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  MCL1 inhibition is synthetic lethal with SMARCA4/2 loss in SCCOHT and NSCLC cells

  nsclc lung smarca4 bin-67 genome-wide drug colony

• Integrated spatial transcriptomics and pan-cancer XGBoost modeling uncover spatial drivers of immune exclusion and predict immunotherapy response.

  PMID 41925746 · PMC13046951 · Cancer immunology, immunotherapy : CII · 2026 · 8 claims · 8 setups

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  A three-step computational framework (ImmCeRNA) identified 6,070 immune-related ceRNA interactions across 27 cancer types by integrating expression correlation and experimental validation data.

  cancer pan-cancer single lung bulk database single-cell

• Machine Learning-Based Integrated Analysis of PANoptosis Patterns in Acute Myeloid Leukemia Reveals a Signature Predicting Survival and Immunotherapy.

  PMID 38322112 · PMC10846924 · International journal of clinical practice · 2024 · 8 claims · 8 setups

  Has reproduction · 71

  AML cases can be categorized into two distinct PANRG (PANoptosis-related gene) clusters with differentially expressed prognostic genes (PRDEGs)

  aml hovon cancer tcga bulk consensus machine

• Synergistic targeting of eIF4A-mediated translation initiation and apoptosis in acute myeloid leukemia.

  PMID 41815287 · PMC12971725 · Blood neoplasia · 2026 · 8 claims · 8 setups

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  EIF4A1 is highly expressed in AML stem- and progenitor-like cells relative to healthy hematopoietic stem/progenitor cells

  healthy aml molm-13 patient-derived single-cell bulk cell-titerglo

• Discovery and Evaluation of Biomarkers for Triple-Negative Breast Cancer Subtypes Uncovers Patient Stratification and Targeted Therapeutic Strategies.

  PMID 41671401 · PMC13176827 · Cancer research · 2026 · 7 claims · 8 setups

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  A set of basal identity genes (SMA/ACTA2, TAGLN, TPM2) defined by scRNA-seq analysis enables subclassification of TNBC into a subgroup termed true basal TNBC (tB-TNBC)

  healthy ffpe tcga i-spy2 scrna-seq immunohistochemistry bulk

• RUVBL1 and RUVBL2 are druggable MYC effector regulators in neuroblastoma cells.

  PMID 41940329 · PMC13049659 · iScience · 2026 · 8 claims · 8 setups

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  RUVBL1 and RUVBL2 target gene sets are significantly depleted in MYCN-driven NB mouse tumors treated with ATR inhibitors (elimusertib, ceralasertib)

  th-mycn neuroblastoma clb-bar clb-ga rna-seq gene western

• Epigenetic and Transcriptional Programs Define Osteosarcoma Subtypes and Establish Targetable Vulnerabilities.

  PMID 41037662 · PMC12877751 · Cancer discovery · 2026 · 8 claims · 7 setups

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  ATAC-seq profiling of osteosarcoma patient samples, PDXs, and PDX-CLs reveals two distinct chromatin accessibility subtypes: early osteoblast-derived (EOD) and late osteoblast-derived (LOD)

  n=8 pdx-derived pdx osteosarcoma atac-seq bulk h3k27ac

• Identification of Cell Subpopulation-Specific Driver Genes Reveals Ideal Candidates for Renal Cell Carcinoma Immunotherapy.

  PMID 42074110 · PMC13115843 · International journal of molecular sciences · 2026 · 8 claims · 8 setups

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  25 immune-related candidate driver genes were identified from tumor, myeloid, and lymphoid cell gene regulatory networks (GRNs) using SCENIC and topological Q statistics.

  kidney lymphoid rcc tcga-kirc single-cell scenic genome-wide

• Systematic elucidation of genetic mechanisms underlying cholesterol uptake.

  PMID 37228746 · PMC10203276 · Cell genomics · 2023 · 8 claims · 8 setups

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  Genome-scale CRISPR-Cas9 knockout screening in HepG2 cells identifies 490 genes whose disruption alters LDL-C uptake

  hepg2 depmap flow genome-scale individual

• KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival.

  PMID 41849608 · PMC12998525 · Science advances · 2026 · 8 claims · 8 setups

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  KLF5 binds subtype-independent highly interactive enhancers in PDAC that interact with essential genes

  classical aspc1 panel l3.6pl atac-seq h3k27ac h3k4me3-anchored