Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Spatial gene expression analysis reveals drivers of extremely early lymph node metastasis in breast cancer.

  PMID 41578129 · PMC12932634 · NPJ breast cancer · 2026 · 8 claims · 7 setups

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  Identified 30 isolated tumor cells (ITCs) in a clinically metastasis-negative tumor-draining lymph node, representing the initial metastatic seeding event, spanning ~200 μm

  dissected same tumor xenium-derived bulk enzymatic whole-genome

• Podoplanin-defined tumour plasticity and CCR7-mediated lymphatic metastasis in triple-negative breast cancer.

  PMID 41957138 · PMC13226698 · British journal of cancer · 2026 · 8 claims · 8 setups

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  A PDPN-defined tumour cell mesenchymal shift, promoted by hypoxia, is required for efficient CCR7-driven lymphatic metastasis and tumour progression

  eo771 c57bl tnbc tumour proliferation tumour flow

• Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade.

  PMID 41593194 · PMC13004670 · Nature medicine · 2026 · 8 claims · 5 setups

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  PD-1 blockade induces tumor-specific IgG1+ plasma cell responses that complement cellular immunity and contribute to clinical benefit

  tumor paired single-cell bulk multiplex

• Pharmacological perturbation of splicing elicits SMG1 reduction: Implications for cancer therapy.

  PMID 41623476 · PMC12857400 · iScience · 2026 · 7 claims · 12 setups

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  Splicing-modulatory drugs MS023 and indisulam act as inadvertent NMD inhibitors by downregulating SMG1 protein levels

  4t1 tumor-draining arst panc02 mts tumor ifn-γ

• Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models.

  PMID 41912536 · PMC13172322 · Nature communications · 2026 · 8 claims · 8 setups

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  ACT with TCR-transgenic (OTI) CD8+ T cells eradicates established B16F10-OTI tumors and expands host CD8+ T cells with tumor-reactive (PD-1+GzmB-/PD-1+GzmB+, Tpex/Tex) and tissue-resident phenotypes

  b16f10-oti draining ragko c57bl flow tumor antibody

• Protocol to annotate dendritic cell maturation types in vivo making use of lipid nanoparticle-based approaches.

  PMID 41811845 · PMC12994025 · STAR protocols · 2026 · 8 claims · 8 setups

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  Different LNP formulations (cargo type, adjuvant presence) can be used to steer DC maturation along a homeostatic-immunogenic spectrum in vivo

  lipid linearized transcribed mc38 lnp transcription agarose