Experiments

Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).

• Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline.

  PMID 12546714 · PMC149328 · BMC genetics · 2003 · 8 claims · 5 setups

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  A human oocyte-specific DNMT1 isoform (DNMT1o), driven by a novel upstream exon 1o, is expressed in mature oocytes and early embryos but not in somatic tissues

  oocytes genomic fbhm population rt-pcr est direct

• Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limb.

  PMID 41253754 · PMC12627582 · Nature communications · 2025 · 8 claims · 8 setups

  Has reproduction · 10

  Gli1+ fetal cells are the precursors of postnatal long-lived chondroprogenitors (LLCPs) in the growth plate

  fetal left-cart-p21 gli1-creer cartilage single-nuclei scenic bulk

• Geometric Reliability of Super-Resolution Reconstructed Images from Clinical Fetal MRI in the Second Trimester.

  PMID 37284977 · PMC10406722 · Neuroinformatics · 2023 · 7 claims · 8 setups

  Has reproduction

  NiftyMIC and MIALSRTK provide reliable SR reconstructed volumes suitable for biometric assessments

  fetal same reconstructed t2w b-ffe super-resolution

• Mapping the Development of Human Spermatogenesis Using Transcriptomics-Based Data: A Scoping Review.

  PMID 39000031 · PMC11241379 · International journal of molecular sciences · 2024 · 8 claims · 8 setups

  Has reproduction

  scRNA-seq of human testis reveals major transcriptional modifications occurring around 11 years of age, marking a transition toward the adult cellular state

  fetal neonatal prepubertal peripubertal scrna-seq

• Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray.

  PMID 16983573 · PMC1705512 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2006 · 8 claims · 5 setups

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  72-83% of assayed miRNAs are expressed across human fetal organs, with G24w cerebrum showing the most miRNAs expressed

  fetal same microarray oligonucleotide northern microarray

• Prenatal molecular diagnosis of beta-thalassemia: report on the first two cases in Romania.

  PMID 20108460 · PMC5654072 · Journal of medicine and life · 2008 · 7 claims · 5 setups

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  Combined DGGE, ARMS-PCR and PCR-RFLP molecular testing accurately detects β-thalassemia mutations in fetal DNA obtained by amniocentesis or CVS

  fetal β-globin parental str denaturing amplification

• Multiomics and deep learning dissect regulatory syntax in human development.

  PMID 41951735 · PMC13216069 · Nature · 2026 · 8 claims · 8 setups

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  The Human Development Multiomic Atlas (HDMA) is a single-cell atlas of chromatin accessibility and gene expression from 817,740 fetal cells across 12 organs, spanning 203 cell types

  fetal annotated embryo chrombpnet share-seq chromvar activity-by-contact

• Single-cell atlas of the developing Down syndrome brain cortex.

  PMID 41545595 · PMC13004680 · Nature medicine · 2026 · 8 claims · 8 setups

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  RORB/FOXP1-expressing L4-like excitatory neurons are subtype-specifically and dramatically reduced in Down syndrome fetal cortex, especially at later stages (PCW16-20)

  fetal excitatory neural humanized single-nucleus immunostaining compositional

• An in vivo and in vitro spatiotemporal profile of human midbrain development.

  PMID 41633979 · PMC12877092 · Nature communications · 2026 · 8 claims · 6 setups

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  By 22 post-conceptional weeks (PCW), fetal ventral midbrain tissue exhibits structural complexity comparable to adult tissue

  fetal ipsc-derived dopamine immunohistochemistry immunofluorescence droplet-based

• pmid-41807357

  PMID 41807357 · PMC13102919 · 7 claims · 7 setups

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  Generated a high-resolution spatial transcriptomic atlas of human fetal (13,14,17,18w) and paediatric (7w,2y,5y,6y) thymi using Stereo-seq, integrated with scRNA-seq and MACSima/Stereo-CITE proteomics

  fetal paediatric thymus stereo-seq scrna-seq macsima

• Gene expression profiles of HIV-1-infected glia and brain: toward better understanding of the role of astrocytes in HIV-1-associated neurocognitive disorders.

  PMID 19697136 · PMC3107560 · Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010 · 8 claims · 6 setups

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  Astrocyte gene expression dysregulation resulting from HIV-1 exposure may contribute to HIV-1 neuropathogenesis

  fetal astrocytes brain macaque rapid microarray correlational

• ASCL1 promotes nuclear shrinkage in transdifferentiation by suppressing NUP37.

  PMID 41759523 · PMC12985393 · Stem cell reports · 2026 · 7 claims · 8 setups

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  ASCL1-mediated transdifferentiation (AMp) of human fibroblasts to induced neurons causes marked nuclear shrinkage while cell size remains unchanged

  mrc5 ag22056 ipsc-derived embryonic immunofluorescence single-cell rt-qpcr

• Reactivation of a developmentally silenced embryonic globin gene.

  PMID 34290235 · PMC8295333 · Nature communications · 2021 · 8 claims · 8 setups

  Has reproduction · 85

  In embryonic (primitive) erythroid cells, the ζ-gene lies within a ~65 kb sub-TAD of open, acetylated chromatin and physically interacts with the α-globin super-enhancer.

  primitive embryos ζ-venus atac-seq dnasei chip-seq

• Characterization, expression profiles, intracellular distribution and association analysis of porcine PNAS-4 gene with production traits.

  PMID 18588709 · PMC2464599 · BMC genetics · 2008 · 8 claims · 7 setups

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  Porcine PNAS-4 encodes a 194-amino-acid protein that localizes to the Golgi complex

  chinese tissues skeletal pk15 full-length real-time gfp

• A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency.

  PMID 41649478 · PMC12880805 · eLife · 2026 · 8 claims · 8 setups

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  Mir195 transduction rescues Ebf1-deficient HPCs, inducing CD19 expression and a B-lineage gene expression program

  wild-type ebf1 nog mir195 flow cdna engraftment

• MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis.

  PMID 41287933 · PMC12848572 · Development (Cambridge, England) · 2026 · 8 claims · 4 setups

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  MEIOC prevents continued mitotic cycling in preleptotene oocytes prior to meiotic entry

  e16.5 e14.5 ovarian edu bulk single-cell

• Microglia maintain structural integrity during fetal brain morphogenesis.

  PMID 38309258 · PMC10869139 · Cell · 2024 · 8 claims · 8 setups

  Has reproduction · 68

  Embryonic ATM-like microglia accumulate at two fetal cortical boundaries, the cortico-striato-amygdalar boundary (CSA) and cortico-septal boundary (CSB), resembling post-natal axon-tract-associated microglia (ATM)

  embryonic cx3cr1 fetal embryos single-cell immunolabeling phrodo

• Early noninvasive prenatal detection of a fetal CRB1 mutation causing Leber congenital amaurosis.

  PMID 18682814 · PMC2493031 · Molecular vision · 2008 · 8 claims · 6 setups

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  dHPLC detected the paternally inherited fetal CRB1 mutation (p.Cys896ter) in maternal plasma collected at 12 weeks gestation

  maternal serial genomic chorion dhplc automated pcr

• Rete ridges form via evolutionarily distinct mechanisms in mammalian skin.

  PMID 41639458 · PMC12959975 · Nature · 2026 · 8 claims · 8 setups

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  Rete ridges form through a mechanism independent from hair follicles and sweat glands, via interconnected epidermal invaginations

  trunk pig multispecies gw12 histology comparative immunostaining

• CellPredX, a computational framework for cross-data type, cross-sample, and cross-protocol cell type annotation through domain adaptation and deep metric learning.

  PMID 41481570 · PMC12758788 · PLoS computational biology · 2026 · 8 claims · 7 setups

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  CellPredX is a unified semi-supervised framework integrating domain adaptation and deep metric learning to align heterogeneous embeddings for cross-modality cell type annotation.

  pbmc fetal pancreas gse149683 matched unmatched cross-protocol