Experiments
Searchable full-text extractions: founding hypothesis, core claims, experimental setups, key results and statistics — pulled out of each paper as structure. Search a cell line, an assay or an entity (e.g. HUH7) and find every paper that worked with it. This corpus stands on its own: most entries carry no reproduction assessment (yet).
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Has reproduction · 37
Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8(+) T cells.
PMID 37081150 · PMC10154250 · Nature immunology · 2023 · 8 claims · 7 setups
Orthogonal engineering with PD1d/IL-2v/IL-33 reprograms adoptively transferred CD8+ T cells into a novel synthetic effector state (C5/TSE) that deviates from canonical TOX+ exhaustion
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BCG-trained macrophages promote pan-anti-tumor activity through epigenetic rewiring of NOX2-ROS axis.
PMID 42032669 · PMC13261971 · Journal of experimental & clinical cancer research : CR · 2026 · 7 claims · 8 setups
BCG training induces pan-anti-tumor activity across multiple mouse tumor models, mediated predominantly by tumor-associated macrophages (TAMs)
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TOPK Suppresses the CD8(+) T Cell Antitumor Immunity via Modulation of IRF5 Expression.
PMID 41868885 · PMC13003159 · Cancer communications (London, England) · 2026 · 8 claims · 8 setups
A TOPK+ subset of tumor-infiltrating CD8+ T cells exists in melanoma at higher frequency than in normal lymph nodes and shows suppressed cytotoxic/cytokine programs.
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Pharmacological perturbation of splicing elicits SMG1 reduction: Implications for cancer therapy.
PMID 41623476 · PMC12857400 · iScience · 2026 · 7 claims · 12 setups
Splicing-modulatory drugs MS023 and indisulam act as inadvertent NMD inhibitors by downregulating SMG1 protein levels